Description of TANZANIA group

For many years CMP has been collaborating with partners in Tanzania. The team is grounded in research activities carried out at district hospitals and at sites for longitudinal population based studies in Tanzania. In collaboration with other research teams at CMP as well as other departments at University of Copenhagen, University hospitals in Denmark, and other European research institutes a number of projects have been and are being carried out.

The people specifically affiliated to the TANZANIA team focuses on clinical and epidemiological aspects of malaria and related conditions, including anemia. In close collaboration with the DRUGS, the VAR2CSA, and the DISCOVERY teams, biological samples collected in Tanzania are being investigated in the laboratory facilities locally and at CMP in order to answer the team’s and collaborators research questions.

Current projects

”FOETALforNCD – Foetal Exposure and Epidemiological Transition: The Role of Anaemia in Early Life for Non-Communicable Diseases in Later Life” 

Epidemiological preconceptional-pregnancy cohort study investigating the effect of anemia before and during pregnancy on placental development, foetal growth, newborn health, and the risk of non-communicable diseases in later life. The role of malaria with and without anaemia is also studied.

VAR2CSA expression and sulfadoxine-pyrimethamine resistance in early pregnancy malaria and the effect on foetal and placental development

Aim at characterizing pathophysiological mechanisms and consequences of 1st, 2nd, and 3rd trimester malaria infections. The focus is on the relative influence of parasite burden, anti-VAR2CSA antibody levels, and resistance against anti-malarial drugs on 1st, 2nd, and 3rd trimester malaria infections and the potential effects on placental angiogenesis, placental blood flow, foetal growth, and birth weight.

IMPROVE - Improving PRegnancy Outcomes with intermittent PReVEntive treatment in Africa

An international multi-centre 3-arm placebo-controlled trial comparing different regimens of intermittent preventive treatment against malaria in pregnancy. The standard regimen of sulphadoxine-pyrimethamine is compared with dihydroartemisinin-piperaquine with or without azithromycin for malaria, sexually transmitted and reproductive tract infections in pregnancy. The trial is conducted in high sulphadoxine-pyrimethamine resistance areas in Kenya, Malawi and Tanzania.

Building Stronger Universities

Over the years, strong emphasis has been on building up research capacities at Tanzanian institutions, mainly as part of Danida funded research projects. Since 2011, CMP with University of Southern Denmark, Danish Technological University (DTU) and Danish Technological Institute (DTI) has been involved in the Building Stronger Universities (BSU) programme at Kilimanjaro Christian Medical University College in Moshi, Tanzania. The third phase of the programme (BSU III) was recently initiated and will run until 2021 and involve both upgrading administrative activities (grant management skills, secure internet access, procurement practices etc.) and research oriented activities (establishment of research teams in malaria, HIV and reproductive health, specialized courses, outreach activities etc.)

ENRECA / MaReCa - Malaria Research and Capacity building for field trials in Tanzania

The variant surface antigens, PfEMP1 and RIFINs, in field malaria parasite isolates and malaria immunity of individuals living in malaria-endemic areas are studied. The parasite geno- and phenotype is investigated in relation to the clinical presentation of malaria (uncomplicated malaria, cerebral malaria, severe malarial anaemia, metabolic acidosis, hyperparasitaemia). Furthermore, the malaria incidence in villages of Korogwe district, Mkokola and Kwamasimba, have been monitored with annual cross-sectional surveys since 2003. Demographic data and biological samples for serological investigations and nucleic acids analyses of parasites are collected.

International Study Exposure – Health Provision in Tropical Africa

In addition to the 3-week course “Summer School in International Health”, UCPH medical students are attached to a clinical department for 8 weeks at a hospital in Tanzania; either Magunga District Hospital in Korogwe or Tanga Regional Referral Hospital in Tanga. The attachment is arranged by the Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, in collaboration with National Institute for Medical Research, Tanzania, Kilimanjaro Christian Medical University College and the hosting hospitals. The purpose of the attachment is to gain experience with health provision and clinical medicine at an institution in the developing world. The stay increases the student’s clinical skills, and gives insight into the disease pattern and the challenges of providing health services in a society with limited health budgets.

For more information about this team, please contact the TANZANIA team leader