TARGETS team

  1. Published

    3D blood-brain barrier-organoids as a model for Lyme neuroborreliosis highlighting genospecies dependent organotropism

    Adams, Yvonne, Clausen, Anne Skovsbo, Jensen, Peter Østrup, Lager, M., Wilhelmsson, P., Henningson, A. J., Lindgren, P. E., Faurholt-Jepsen, D., Mens, H., Kraiczy, P., Kragh, K. N., Bjarnsholt, Thomas, Kjær, Andreas, Lebech, Anne-Mette & Jensen, Anja Ramstedt, 2023, In: iScience. 26, 1, 105838.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    3D organoid assay of the impact of infected erythrocyte adhesion on the blood-brain barrier

    Adams, Yvonne & Jensen, Anja Ramstedt, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Humana Press, Vol. 2470. p. 587-599 13 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  3. Published

    3D7-derived Plasmodium falciparum erythrocyte membrane protein 1 is a frequent target of naturally acquired antibodies recognizing protein domains in a particular pattern independent of malaria transmission intensity

    Joergensen, L., Vestergaard, L. S., Turner, Louise, Magistrado, P., Lusingu, J. P., Lemnge, M., Theander, Thor Grundtvig & Jensen, Anja Ramstedt, 2007, In: Journal of Immunology. 178, 1, p. 428-35 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    In vitro selection for adhesion of Plasmodium falciparum-infected erythrocytes to ABO antigens does not affect PfEMP1 and RIFIN expression

    van der Puije, W., Wang, Christian William, Sudharson, S., Hempel, C., Olsen, Rebecca Wendelboe, Dalgaard, Nanna, Ofori, M. F., Hviid, Lars, Kurtzhals, Jørgen & Staalsø, Trine, 2020, In: Scientific Reports. 10, 1, p. 12871 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood-brain barrier in cerebral malaria

    Adams, Yvonne, Olsen, Rebecca Wendelboe, Bengtsson, A., Dalgaard, Nanna, Zdioruk, M., Satpathi, S., Behera, P. K., Sahu, P. K., Lawler, S. E., Qvortrup, Klaus, Wassmer, S. C. & Jensen, Anja Ramstedt, 2021, In: The Journal of Experimental Medicine. 218, 3, 16 p., e20201266.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A Method for Positive and Negative Selection of Plasmodium falciparum Platelet-Mediated Clumping Parasites and Investigation of the Role of CD36

    Arman, M., Adams, Yvonne, Lindergard, G. & Rowe, J. A., 6 Feb 2013, In: PLoS ONE. 8, 2, e55453.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

    Bengtsson, A., Joergensen, L., Rask, T. S., Olsen, R. W., Andersen, M. A., Turner, Louise, Theander, Thor Grundtvig, Hviid, Lars, Higgins, M. K., Craig, A., Brown, A. & Jensen, Anja Ramstedt, 2013, In: Journal of Immunology. 190, 1, p. 240-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes

    Bengtsson, D., Sowa, K. M., Salanti, Ali, Jensen, Anja Ramstedt, Joergensen, L., Turner, Louise, Theander, Thor Grundtvig & Arnot, D. E., 2008, In: Malaria Journal. 7, p. 101

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    A semi-automated multiplex high-throughput assay for measuring IgG antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasma

    Cham, G. K. K., Kurtis, J., Lusingu, J., Theander, Thor Grundtvig, Jensen, Anja Ramstedt & Turner, Louise, 2008, In: Malaria Journal. 7, p. 108

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    A specific PfEMP1 is expressed in P. falciparum sporozoites and plays a role in hepatocyte infection

    Zanghì, G., Vembar, S. S., Baumgarten, S., Ding, S., Guizetti, J., Bryant, J. M., Mattei, D., Jensen, A. T. R., Rénia, L., Goh, Y. S., Sauerwein, R., Hermsen, C. C., Franetich, J-F., Bordessoulles, M., Silvie, O., Soulard, V., Scatton, O., Chen, P., Mecheri, S., Mazier, D. & 1 others, Scherf, A., 2018, In: Cell Reports. 22, 11, p. 2951-2963 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    A vaccine targeted specifically to prevent cerebral malaria - is there hope?

    Hviid, Lars, Lavstsen, Thomas & Jensen, Anja Ramstedt, Jul 2018, In: Expert Review of Vaccines. 17, 7, p. 565-567 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  12. Published

    Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C

    Olsen, Rebecca Wendelboe, Ecklu-Mensah, G., Bengtsson, A., Ofori, M. F., Kusi, K. A., Koram, K. A., Hviid, Lars, Adams, Yvonne & Jensen, Anja Ramstedt, 2019, In: Infection and Immunity. 87, 10, e00224-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Activated integrins identify functional antigen-specific CD8 T cells within minutes after antigen stimulation

    Dimitrov, S., Gouttefangeas, C., Besedovsky, L., Jensen, Anja Ramstedt, Chandran, P. A., Rusch, E., Businger, R., Schindler, M., Lange, T., Born, J. & Rammensee, H., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 24, p. E5536-E5545

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Affinity purification of PfEMP1-specific antibodies from human blood

    Olsen, Rebecca Wendelboe, Suurbaar, Jennifer & Jensen, Anja Ramstedt, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Humana Press, Vol. 2470. p. 369-379 11 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  15. Published

    An analysis of the binding characteristics of a panel of recently selected ICAM-1 binding Plasmodium falciparum patient isolates

    Madkhali, A. M., Alkurbi, M. O., Szestak, T., Bengtsson, A., Patil, P. R., Wu, Y., Alharthi, S., Jensen, Anja Ramstedt, Pleass, R. & Craig, A. G., 2014, In: PLOS ONE. 9, 10, 8 p., e111518.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Analysis of Single-cell Gene Transcription by RNA Fluorescent In Situ Hybridization (FISH)

    Ronander, E., Bengtsson, D. C., Joergensen, L., Jensen, Anja Ramstedt & Arnot, D. E., 2012, In: Journal of Visualized Experiments. 68

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Analysis of antibody inhibition of PfEMP1 binding by competition ELISA

    Olsen, Rebecca Wendelboe, Suurbaar, Jennifer & Jensen, Anja Ramstedt, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Humana Press, Vol. 2470. p. 485-491 7 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  18. Published

    Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

    Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Goksøyr, L., Olsen, Rebecca Wendelboe, Fanalista, Margherita, Augestad, Elias Honerød, Thrane, Susan, Pihl, A. F., Gottwein, Judith Margarete, Sander, Adam F. & Bukh, Jens, 2021, In: PLoS ONE. 16, e0255336.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Antigenic variation and the genetics and epigenetics of the PfEMP1 erythrocyte surface antigens in Plasmodium falciparum malaria

    Arnot, D. E. & Jensen, Anja Ramstedt, 2011, In: Advances in Applied Microbiology. 74, p. 77-96 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes

    Ecklu-Mensah, G., Olsen, Rebecca Wendelboe, Bengtsson, A., Ofori, M. F., Hviid, Lars, Jensen, Anja Ramstedt & Adams, Yvonne, 2018, In: PLoS ONE. 13, 10, 12 p., e0204177.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Breadth of antibodies to Plasmodium falciparum variant surface antigens is associated with immunity in a controlled human malaria infection study

    CHMI-SIKA Study Team, C. S. T., 2022, In: Frontiers in Immunology. 13, 10 p., 894770.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    CD36 selection of 3D7 Plasmodium falciparum associated with severe childhood malaria results in reduced VAR4 expression

    Magistrado, P., Staalsoe, T., Theander, Thor Grundtvig, Hviid, Lars & Jensen, Anja Ramstedt, 2008, In: Malaria Journal. 7, 1, p. 204

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Carrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36

    Adams, Yvonne, Smith, S. L., Schwartz-Albiez, R. & Andrews, K. T., Oct 2005, In: Parasitology Research. 97, 4, p. 290-294 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it

    Jensen, Anja Ramstedt, Adams, Yvonne & Hviid, Lars, 2020, In: Immunological Reviews. 293, 1, p. 230-252

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Cerebral malaria - modelling interactions at the blood-brain barrier in vitro

    Adams, Yvonne & Jensen, Anja Ramstedt, 2022, In: Disease models & mechanisms. 15, 7, dmm049410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Characterizing the impact of sustained sulfadoxine/pyrimethamine use upon the Plasmodium falciparum population in Malawi

    Ravenhall, M., Benavente, E. D., Mipando, M., Jensen, Anja Ramstedt, Sutherland, C. J., Roper, C., Sepúlveda, N., Kwiatkowski, D. P., Montgomery, J., Phiri, K. S., Terlouw, A., Craig, A., Campino, S., Ocholla, H. & Clark, T. G., 29 Nov 2016, In: Malaria Journal. 15, 11 p., 575.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Chip-based assay of adhesion of Plasmodium falciparum-infected erythrocytes to cells under flow

    Adams, Yvonne & Jensen, Anja Ramstedt, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Jensen, A. T. R. & Hviid, L. (eds.). Humana Press, p. 545-556 12 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  28. Published

    Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones

    Quintana Varon, Maria del Pilar, Ecklu-Mensah, G., Tcherniuk, S. O., Ditlev, S. B., Oleinikov, A. V., Hviid, Lars & Lopez-Perez, Mary, 2019, In: Scientific Reports. 9, 1, 11 p., 6050.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Effect of cytokine treatment on the in vitro expression of the P. falciparum adhesion receptor chondroitin-4-sulphate on the surface of human choriocarcinoma (BeWo) cells

    Adams, Yvonne, Schwartz-Albiez, R., McCarthy, J. S. & Andrews, K. T., Jul 2007, In: Parasitology Research. 101, 2, p. 479-483 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

    Zhang, Q., Siegel, T. N., Martins, R. M., Wang, F., Cao, J., Gao, Q., Cheng, X., Jiang, L., Hon, C., Scheidig-Benatar, C., Sakamoto, H., Turner, Louise, Jensen, Anja Ramstedt, Claes, A., Guizetti, J., Malmquist, N. A. & Scherf, A., 2014, In: Nature. 531, p. 431-435

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Gαs-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells

    Dimitrov, S., Lange, T., Gouttefangeas, C., Jensen, Anja Ramstedt, Szczepanski, M., Lehnnolz, J., Soekadar, S., Rammensee, H., Born, J. & Besedovsky, L., 2019, In: The Journal of Experimental Medicine. 216, 3, p. 517-526 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children

    Cham, G. K. K., Turner, Louise, Kurtis, J. D., Mutabingwa, T., Fried, M., Jensen, Anja Ramstedt, Lavstsen, Thomas, Hviid, Lars, Duffy, P. E. & Theander, Thor Grundtvig, 2010, In: Infection and Immunity. 78, 11, p. 4653-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    ICAM-1-binding Plasmodium falciparum erythrocyte membrane protein 1 variants elicits opsonic-phagocytosis IgG responses in Beninese children

    Suurbaar, Jennifer, Moussiliou, A., Tahar, R., Olsen, Rebecca Wendelboe, Adams, Yvonne, Dalgaard, Nanna, Baafour, E. K., Adukpo, S., Hviid, Lars, Kusi, K. A., Alao, J., Ofori, M. F., Ndam, N. T. & Jensen, Anja Ramstedt, 2022, In: Scientific Reports. 12, 12994.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts

    Kurbegovic, Sorel, Stræde, Karina, Sørensen, K. K., Leth, Julie Maja, Willemoe, G. L., Christensen, Anders, Adams, Yvonne, Jensen, Anja Ramstedt, von Buchwald, Christian, Skjøth-rasmussen, J., Ploug, Michael, Jensen, Knud Jørgen & Kjær, Andreas, 2021, In: Theranostics. 11, 15, p. 7159-7174 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria

    Magistrado, P. A., Lusingu, J., Vestergaard, L. S., Lemnge, M., Lavstsen, Thomas, Turner, Louise, Hviid, Lars, Jensen, Anja Ramstedt & Theander, Thor Grundtvig, 2007, In: Infection and Immunity. 75, 5, p. 2415-20 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Immunomagnetic Selection of Plasmodium falciparum–Infected Erythrocytes Expressing Particular PfEMP1 Variants

    Lopez-Perez, Mary & Olsen, Rebecca Wendelboe, 2022, Methods in Molecular Biology: Targeting the Surface of Infected Erythrocytes. Humana Press, p. 69-78 10 p. (Methods in Molecular Biology, Vol. 2470).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  37. Published

    Induction of strain-transcending antibodies against group A PfEMP1 surface antigens from virulent malaria parasites

    Ghumra, A., Semblat, J. P., Ataide, R., Kifude, C., Adams, Yvonne, Claessens, A., Anong, D. N., Bull, P. C., Fennell, C., Arman, M., Amambua-Ngwa, A., Walther, M., Conway, D. J., Kassambara, L., Doumbo, O. K., Raza, A. & Rowe, J. A., Apr 2012, In: PLoS Pathogens. 8, 4, e1002665.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides

    Adams, Yvonne, Freeman, C., Schwartz-Albiez, R., Ferro, V., Parish, C. R. & Andrews, K. T., Aug 2006, In: Antimicrobial Agents and Chemotherapy. 50, 8, p. 2850-2852 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Insect cells are superior to Escherichia coli in producing malaria proteins inducing IgG targeting PfEMP1 on infected erythrocytes

    Victor, M. E., Bengtsson, A., Andersen, G., Bengtsson, D., Lusingu, J. P., Vestergaard, L. S., Arnot, D. E., Theander, Thor Grundtvig, Joergensen, L. & Jensen, Anja Ramstedt, 2010, In: Malaria Journal. 9, p. 325

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Integrin activation enables sensitive detection of functional CD4+ and CD8+ T cells: Application to characterize SARS-CoV-2 immunity

    Schöllhorn, A., Schuhmacher, J., Besedovsky, L., Fendel, R., Jensen, Anja Ramstedt, Stevanović, S., Lange, T., Rammensee, H., Born, J., Gouttefangeas, C. & Dimitrov, S., 2021, In: Frontiers in Immunology. 12, 626308.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Malaria immunology: Targeting the surface of infected erythrocytes

    Jensen, Anja Ramstedt (ed.) & Hviid, Lars (ed.), 2022, Humana Press. 796 p. (Methods in Molecular Biology, Vol. 2470).

    Research output: Book/ReportBookResearchpeer-review

  42. Published

    Mapping the binding site of a cross-reactive Plasmodium falciparum PfEMP1 monoclonal antibody inhibitory of ICAM-1 binding

    Lennartz, F., Bengtsson, A., Olsen, Rebecca Wendelboe, Joergensen, L., Brown, A., Remy, L., Man, P., Forest, E., Barfod, Lea Klingenberg, Adams, Yvonne, Higgins, M. K. & Jensen, Anja Ramstedt, 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 7, p. 3273-83 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Natural and vaccine-induced acquisition of cross-reactive IgG inhibiting ICAM-1-specific binding of a Plasmodium falciparum PfEMP1 subtype associated specifically with cerebral malaria

    Olsen, Rebecca Wendelboe, Ecklu-Mensah, G., Bengtsson, A., Ofori, M. F., Lusingu, J. P. A., Castberg, F. C., Hviid, Lars, Adams, Yvonne & Jensen, Anja Ramstedt, 2018, In: Infection and Immunity. 86, 4, 17 p., e00622-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria

    Zelter, T., Strahilevitz, J., Simantov, K., Yajuk, O., Adams, Yvonne, Jensen, Anja Ramstedt, Dzikowski, R. & Granot, Z., 2022, In: EMBO Reports. 23, e53641.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Parasites causing cerebral falciparum malaria bind multiple endothelial receptors and express EPCR and ICAM-1-binding PfEMP1

    Tuikue Ndam, N., Moussiliou, A., Lavstsen, Thomas, Kamaliddin, C., Jensen, Anja Ramstedt, Mama, A., Tahar, R., Wang, Christian William, Jespersen, Jakob Schmidt, Alao, J. M., Gamain, B., Theander, Thor Grundtvig & Deloron, P., 2017, In: The Journal of Infectious Diseases. 215, 12, p. 1918-1925 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. E-pub ahead of print

    PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity

    Hviid, Lars, Jensen, Anja Ramstedt & Deitsch, K. W., 2024, (E-pub ahead of print) Advances in Parasitology. Academic Press, 51 p. (Advances in Parasitology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  47. Published

    PfEMP1 – a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

    Hviid, Lars & Jensen, Anja Ramstedt, Apr 2015, Advances in Parasitology. Rollinson, D. & Stothard, J. R. (eds.). Vol. 88. p. 51-84 34 p. (Advances in Parasitology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  48. Published

    PfEMP1-specific immunoglobulin G reactivity among Beninese pregnant women with sickle cell trait

    Lopez-Perez, Mary, Viwami, F., Seidu, Zakaria, Jensen, Anja Ramstedt, Doritchamou, J., Ndam, N. T. & Hviid, Lars, 2021, In: Open Forum Infectious Diseases. 8, 12, ofab527.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Potential impact of host immunity on malaria treatment outcome in Tanzanian children infected with Plasmodium falciparum

    Enevold, A., Nkya, W. M. M. M., Theisen, M., Vestergaard, L. S., Jensen, Anja Ramstedt, Staalsoe, T., Theander, Thor Grundtvig, Bygbjerg, Ib Christian & Alifrangis, Michael, 2007, In: Malaria Journal. 6, p. 153

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Production of anti-PfEMP1 polyclonal antisera in rats and mice

    Olsen, Rebecca Wendelboe, Suurbaar, Jennifer & Jensen, Anja Ramstedt, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Jensen, A. T. R. & Hviid, L. (eds.). Humana Press, Vol. 2470. p. 381-389 9 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

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