PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
The most severe form of malaria, caused by infection with Plasmodium falciparum parasites, continues to be an important cause of human suffering and poverty. The P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens, which mediates the adhesion of infected erythrocytes to the vascular endothelium in various tissues and organs, is a central component of the pathogenesis of the disease and a key target of the acquired immune response to malaria. Much new knowledge has accumulated since we published a systematic overview of the PfEMP1 family almost ten years ago. In this chapter, we therefore aim to summarize research progress since 2015 on the structure, function, regulation etc. of this key protein family of arguably the most important human parasite. Recent insights regarding PfEMP1-specific immune responses and PfEMP1-specific vaccination against malaria, as well as an outlook for the coming years are also covered.
Original language | English |
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Title of host publication | Advances in Parasitology |
Number of pages | 51 |
Publisher | Academic Press |
DOIs | |
Publication status | E-pub ahead of print - 2024 |
Series | Advances in Parasitology |
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ISSN | 0065-308X |
Bibliographical note
Publisher Copyright:
© 2024
- Immunity, Malaria, Pathogenesis, PfEMP1, Plasmodium falciparum, Structure/function, Vaccine, var genes
Research areas
ID: 388045147