PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity. / Hviid, Lars; Jensen, Anja R.; Deitsch, Kirk W.

Advances in Parasitology. Academic Press, 2024. (Advances in Parasitology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Hviid, L, Jensen, AR & Deitsch, KW 2024, PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity. in Advances in Parasitology. Academic Press, Advances in Parasitology. https://doi.org/10.1016/bs.apar.2024.02.001

APA

Hviid, L., Jensen, A. R., & Deitsch, K. W. (2024). PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity. In Advances in Parasitology Academic Press. Advances in Parasitology https://doi.org/10.1016/bs.apar.2024.02.001

Vancouver

Hviid L, Jensen AR, Deitsch KW. PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity. In Advances in Parasitology. Academic Press. 2024. (Advances in Parasitology). https://doi.org/10.1016/bs.apar.2024.02.001

Author

Hviid, Lars ; Jensen, Anja R. ; Deitsch, Kirk W. / PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity. Advances in Parasitology. Academic Press, 2024. (Advances in Parasitology).

Bibtex

@inbook{65293403f88a4de2a416d16ad0e24100,
title = "PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity",
abstract = "The most severe form of malaria, caused by infection with Plasmodium falciparum parasites, continues to be an important cause of human suffering and poverty. The P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens, which mediates the adhesion of infected erythrocytes to the vascular endothelium in various tissues and organs, is a central component of the pathogenesis of the disease and a key target of the acquired immune response to malaria. Much new knowledge has accumulated since we published a systematic overview of the PfEMP1 family almost ten years ago. In this chapter, we therefore aim to summarize research progress since 2015 on the structure, function, regulation etc. of this key protein family of arguably the most important human parasite. Recent insights regarding PfEMP1-specific immune responses and PfEMP1-specific vaccination against malaria, as well as an outlook for the coming years are also covered.",
keywords = "Immunity, Malaria, Pathogenesis, PfEMP1, Plasmodium falciparum, Structure/function, Vaccine, var genes",
author = "Lars Hviid and Jensen, {Anja R.} and Deitsch, {Kirk W.}",
note = "Publisher Copyright: {\textcopyright} 2024",
year = "2024",
doi = "10.1016/bs.apar.2024.02.001",
language = "English",
series = "Advances in Parasitology",
publisher = "Academic Press",
booktitle = "Advances in Parasitology",
address = "United Kingdom",

}

RIS

TY - CHAP

T1 - PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity

AU - Hviid, Lars

AU - Jensen, Anja R.

AU - Deitsch, Kirk W.

N1 - Publisher Copyright: © 2024

PY - 2024

Y1 - 2024

N2 - The most severe form of malaria, caused by infection with Plasmodium falciparum parasites, continues to be an important cause of human suffering and poverty. The P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens, which mediates the adhesion of infected erythrocytes to the vascular endothelium in various tissues and organs, is a central component of the pathogenesis of the disease and a key target of the acquired immune response to malaria. Much new knowledge has accumulated since we published a systematic overview of the PfEMP1 family almost ten years ago. In this chapter, we therefore aim to summarize research progress since 2015 on the structure, function, regulation etc. of this key protein family of arguably the most important human parasite. Recent insights regarding PfEMP1-specific immune responses and PfEMP1-specific vaccination against malaria, as well as an outlook for the coming years are also covered.

AB - The most severe form of malaria, caused by infection with Plasmodium falciparum parasites, continues to be an important cause of human suffering and poverty. The P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens, which mediates the adhesion of infected erythrocytes to the vascular endothelium in various tissues and organs, is a central component of the pathogenesis of the disease and a key target of the acquired immune response to malaria. Much new knowledge has accumulated since we published a systematic overview of the PfEMP1 family almost ten years ago. In this chapter, we therefore aim to summarize research progress since 2015 on the structure, function, regulation etc. of this key protein family of arguably the most important human parasite. Recent insights regarding PfEMP1-specific immune responses and PfEMP1-specific vaccination against malaria, as well as an outlook for the coming years are also covered.

KW - Immunity

KW - Malaria

KW - Pathogenesis

KW - PfEMP1

KW - Plasmodium falciparum

KW - Structure/function

KW - Vaccine

KW - var genes

UR - http://www.scopus.com/inward/record.url?scp=85188725553&partnerID=8YFLogxK

U2 - 10.1016/bs.apar.2024.02.001

DO - 10.1016/bs.apar.2024.02.001

M3 - Book chapter

AN - SCOPUS:85188725553

T3 - Advances in Parasitology

BT - Advances in Parasitology

PB - Academic Press

ER -

ID: 388045147