Enhanced depletion of glutathione and increased liver oxidative damage in aflatoxin-fed mice infected with Plasmodium berghei
Research output: Contribution to journal › Journal article › Research › peer-review
The effect of dietary aflatoxins B1 and G1 and Plasmodium berghei infection on glutathione (GSH) levels and liver status in mice was investigated. Three days after intraperitoneal injection of 0.1 x 10(6) parasitized red blood cells into the mice, there was a significant fall in blood glutathione levels accompanied by a significant increase in serum cholinesterase and liver malonic dialdehyde levels in the mice fed aflatoxin compared with those in the control group. The results suggested that malaria parasites can enhance depletion of host glutathione and oxidative damage of the liver in mice fed low levels of aflatoxins.
Original language | English |
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Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene |
Volume | 89 |
Issue number | 1 |
Pages (from-to) | 59-61 |
Number of pages | 2 |
ISSN | 0035-9203 |
Publication status | Published - 1995 |
Bibliographical note
Keywords: Aflatoxin B1; Aflatoxins; Animals; Female; Glutathione; Liver; Liver Diseases, Parasitic; Malaria; Male; Mice; Parasitemia; Plasmodium berghei
ID: 18081117