Enhanced depletion of glutathione and increased liver oxidative damage in aflatoxin-fed mice infected with Plasmodium berghei
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Enhanced depletion of glutathione and increased liver oxidative damage in aflatoxin-fed mice infected with Plasmodium berghei. / Ankrah, N A; Sittie, A; Addo, P G; Ekuban, F A.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 89, No. 1, 1995, p. 59-61.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Enhanced depletion of glutathione and increased liver oxidative damage in aflatoxin-fed mice infected with Plasmodium berghei
AU - Ankrah, N A
AU - Sittie, A
AU - Addo, P G
AU - Ekuban, F A
N1 - Keywords: Aflatoxin B1; Aflatoxins; Animals; Female; Glutathione; Liver; Liver Diseases, Parasitic; Malaria; Male; Mice; Parasitemia; Plasmodium berghei
PY - 1995
Y1 - 1995
N2 - The effect of dietary aflatoxins B1 and G1 and Plasmodium berghei infection on glutathione (GSH) levels and liver status in mice was investigated. Three days after intraperitoneal injection of 0.1 x 10(6) parasitized red blood cells into the mice, there was a significant fall in blood glutathione levels accompanied by a significant increase in serum cholinesterase and liver malonic dialdehyde levels in the mice fed aflatoxin compared with those in the control group. The results suggested that malaria parasites can enhance depletion of host glutathione and oxidative damage of the liver in mice fed low levels of aflatoxins.
AB - The effect of dietary aflatoxins B1 and G1 and Plasmodium berghei infection on glutathione (GSH) levels and liver status in mice was investigated. Three days after intraperitoneal injection of 0.1 x 10(6) parasitized red blood cells into the mice, there was a significant fall in blood glutathione levels accompanied by a significant increase in serum cholinesterase and liver malonic dialdehyde levels in the mice fed aflatoxin compared with those in the control group. The results suggested that malaria parasites can enhance depletion of host glutathione and oxidative damage of the liver in mice fed low levels of aflatoxins.
M3 - Journal article
C2 - 7747309
VL - 89
SP - 59
EP - 61
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
IS - 1
ER -
ID: 18081117