SURFACE team

  1. 2007
  2. Published

    Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA

    Barfod, Lea Klingenberg, Bernasconi, N. L., Dahlbäck, M., Jarrossay, D., Andersen, P. H., Salanti, Ali, Ofori, M. F., Turner, Louise, Resende, M., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sallusto, F., Lanzavecchia, A. & Hviid, Lars, 2007, In: Molecular Microbiology. 63, 2, p. 335-47 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2008
  4. Published

    Malaria vaccines: immunity, models and monoclonal antibodies

    Hviid, Lars & Barfod, Lea Klingenberg, 2008, In: Trends in Parasitology. 24, 9, p. 392-395 3 p.

    Research output: Contribution to journalReviewResearchpeer-review

  5. 2009
  6. Published

    Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens

    Soerli, J., Barfod, Lea Klingenberg, Lavstsen, Thomas, Bernasconi, N. L., Lanzavecchia, A. & Hviid, Lars, 2009, In: Parasite Immunology. 31, 6, p. 341-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2010
  8. Published

    Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants

    Barfod, Lea Klingenberg, Dobrilovic, T., Magistrado, P., Khunrae, P., Viwami, F., Bruun, J., Dahlbäck, M., Bernasconi, N. L., Fried, M., John, D., Duffy, P. E., Salanti, Ali, Lanzavecchia, A., Lim, C. T., Ndam, N. T., Higgins, M. K. & Hviid, Lars, 2010, In: Journal of Immunology. 185, 12, p. 7553-61 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Exit mechanisms of intracellular parasites from their host cells,Mecanismos de salida de parásitos intracelulares de su célula hospedera

    Quintana Varon, Maria del Pilar, León, S., Forero, M. E. & Camacho, M., 2010, In: Acta Biologica Colombiana.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children

    Cham, G. K. K., Turner, Louise, Kurtis, J. D., Mutabingwa, T., Fried, M., Jensen, Anja Ramstedt, Lavstsen, Thomas, Hviid, Lars, Duffy, P. E. & Theander, Thor Grundtvig, 2010, In: Infection and Immunity. 78, 11, p. 4653-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Immune selection and within-host competition can structure the repertoire of variant surface antigens in Plasmodium falciparum -a mathematical model

    van Noort, S. P., Nunes, M. C., Weedall, G. D., Hviid, Lars & Gomes, M. G. M., 2010, In: PLoS ONE. 5, 3, p. e9778

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Of mice and women: rodent models of placental malaria

    Hviid, Lars, Marinho, C. R. F., Staalsø, Trine & Penha-Gonçalves, C., 2010, In: Trends in Parasitology. 26, 8, p. 412-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs

    Joergensen, L. M., Salanti, Ali, Dobrilovic, T., Barfod, Lea Klingenberg, Hassenkam, Tue, Theander, Thor Grundtvig, Hviid, Lars & Arnot, D. E., 2010, In: Malaria Journal. 9, 1, p. 100

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development

    Hviid, Lars, 2010, In: Human Vaccines. 6, 1, p. 84-89 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Mecanismos de salida de parásitos intracelulares de su célula hospedera

    Quintana Varon, Maria del Pilar, León, S., Forero, M. E. & Camacho, M., 1 Sep 2010, In: Acta Biologica Colombiana. 15, 3, p. 19-32 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  16. 2011
  17. Published

    Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1

    Barfod, Lea Klingenberg, Dalgaard, M. B., Pleman, S. T., Ofori, M. F., Pleass, R. J. & Hviid, Lars, 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 30, p. 12485-90 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Host cell egress by intracellular protozoan parasites

    Garcia, L. M., Quintana Varon, Maria del Pilar & Camacho, M., 2011.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  19. Published

    The case for PfEMP1-based vaccines to protect pregnant women against Plasmodium falciparum malaria

    Hviid, Lars, 2011, In: Expert Review of Vaccines. 10, 10, p. 1405-14 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2012
  21. Published

    Aligned hemozoin crystals in curved clusters in malarial red blood cells revealed by nanoprobe X-ray Fe fluorescence and diffraction

    Kapishnikov, S., Berthing, T., Hviid, Lars, Dierolf, M., Menzel, A., Pfeiffer, F., Als-Nielsen, Jens & Leiserowitz, L., 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11184-7 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia

    Boeuf, P. S., Loizon, S., Awandare, G. A., Tetteh, J. K., Addae, M. M., Adjei, G. O., Goka, B., Kurtzhals, Jørgen, Puijalon, O., Hviid, Lars, Akanmori, B. D. & Behr, C., 2012, In: Malaria Journal. 11, 1, p. 253

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The density of knobs on Plasmodium falciparum-infected erythrocytes depends on developmental age and varies among isolates

    Quadt, K. A., Barfod, Lea Klingenberg, Andersen, D., Bruun, J., Gyan, B., Hassenkam, Tue, Ofori, M. F. & Hviid, Lars, 2012, In: P L o S One. 7, 9, p. e45658

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Plasmodium falciparum Rosetting Epitopes Converge in the SD3-Loop of PfEMP1-DBL1α

    Angeletti, D., Albrecht, L., Blomqvist, K., Quintana Varon, Maria del Pilar, Akhter, T., Bächle, S. M., Sawyer, A., Sandalova, T., Achour, A., Wahlgren, M. & Moll, K., 5 Dec 2012, In: PLOS ONE. 7, 12, e50758.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2013
  26. Published

    A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

    Bengtsson, A., Joergensen, L., Rask, T. S., Olsen, R. W., Andersen, M. A., Turner, Louise, Theander, Thor Grundtvig, Hviid, Lars, Higgins, M. K., Craig, A., Brown, A. & Jensen, Anja Ramstedt, 2013, In: Journal of Immunology. 190, 1, p. 240-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Plasmodium falciparum Expressing Domain Cassette 5 Type PfEMP1 (DC5-PfEMP1) Bind PECAM1

    Berger, S. S., Turner, Louise, Wang, Christian William, Petersen, J. E. V., Kraft, M., Lusingu, J. P. A., Mmbando, B., Marquard, A. M., Bengtsson, D. B. A. C., Hviid, Lars, Nielsen, Morten Agertoug, Theander, Thor Grundtvig & Lavstsen, Thomas, 2013, In: PloS one. 8, 7, p. e69117

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Transfected HEK293 Cells Expressing Functional Recombinant Intercellular Adhesion Molecule 1 (ICAM-1) - A Receptor Associated with Severe Plasmodium falciparum Malaria

    Bengtsson, A., Joergensen, L., Barbati, Z. R., Craig, A., Hviid, Lars & Jensen, Anja Ramstedt, 2013, In: PLOS ONE. 8, 7, p. e69999

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Malaria

    Riley, E. M., Hviid, Lars & Theander, Thor Grundtvig, 22 Oct 2013, Parasitic Infections and the Immune System. Elsevier Science Inc., p. 119-143 25 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  30. Published

    Cytokine response to pregnancy-associated recrudescence of Plasmodium berghei infection in mice with pre-existing immunity to malaria

    Megnekou, R., Staalsø, Trine & Hviid, Lars, 1 Nov 2013, In: Malaria Journal. 12, 1, p. 387

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2014
  32. Published

    Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

    Sleebs, B. E., Lopaticki, S., Marapana, D. S., O'Neill, M. T., Rajasekaran, P., Gazdik, M., Günther, S., Whitehead, L. W., Lowes, K. N., Barfod, Lea Klingenberg, Hviid, Lars, Shaw, P. J., Hodder, A. N., Smith, B. J., Cowman, A. F. & Boddey, J. A., 2014, In: P L o S Biology. 12, 7, p. e1001897

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Modeling malaria infection and immunity against variant surface antigens in Príncipe island, West Africa

    Bandeiras, C., Trovoada, M. J., Gonçalves, L. A., Marinho, C. R. F., Turner, Louise, Hviid, Lars, Penha-Gonçalves, C. & Gomes, M. G. M., 2014, In: PloS one. 9, 2, p. e88110

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The Malaria Pigment Hemozoin Comprises at Most Four Different Isomer Units in Two Crystalline Models: Chiral as Based on a Biochemical Hypothesis or Centrosymmetric Made of Enantiomorphous Sectors

    Straasø, T., Marom, N., Solomonov, I., Barfod, Lea Klingenberg, Burghammer, M., Feidenhans'l, Robert Krarup, Als-Nielsen, Jens & Leiserowitz, L., 17 Mar 2014, In: Crystal Growth & Design. 14, 4, p. 1543-1554 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    B-cell responses to pregnancy-restricted and -unrestricted Plasmodium falciparum erythrocyte membrane protein 1 antigens in Ghanaian women naturally exposed to malaria parasites

    Ampomah, P., Stevenson, L., Ofori, M. F., Barfod, Lea Klingenberg & Hviid, Lars, May 2014, In: Infection and Immunity. 82, 5, p. 1860-71 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Kinetics of B Cell responses to Plasmodium falciparum erythrocyte membrane protein 1 in Ghanaian women naturally exposed to malaria parasites

    Ampomah, P., Stevenson, L., Ofori, M. F., Barfod, Lea Klingenberg & Hviid, Lars, 1 Jun 2014, In: Journal of Immunology. 192, 11, p. 5236-44 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2015
  38. Published

    Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed

    Subramani, R., Quadt, K., Jeppesen, A. E., Hempel, C., Petersen, J. E. V., Hassenkam, Tue, Hviid, Lars & Barfod, Lea Klingenberg, 2015, In: mBio. 6, 5, 7 p., e01456-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Mapping the binding site of a cross-reactive Plasmodium falciparum PfEMP1 monoclonal antibody inhibitory of ICAM-1 binding

    Lennartz, F., Bengtsson, A., Olsen, Rebecca Wendelboe, Joergensen, L., Brown, A., Remy, L., Man, P., Forest, E., Barfod, Lea Klingenberg, Adams, Yvonne, Higgins, M. K. & Jensen, Anja Ramstedt, 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 7, p. 3273-83 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Multiple Plasmodium falciparum erythrocyte membrane protein 1 variants per genome can bind IgM via its Fc fragment Fcμ

    Jeppesen, A., Ditlev, S. B., Soroka, V., Stevenson, E. K., Turner, Louise, Dzikowski, R., Hviid, Lars & Barfod, Lea Klingenberg, 2015, In: Infection and Immunity. 83, 10, p. 3972-81 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Trying to remember: immunological B cell memory to malaria

    Hviid, Lars, Barfod, Lea Klingenberg & Fowkes, F. J. I., Mar 2015, In: Trends in Parasitology. 31, 3, p. 89-94 6 p.

    Research output: Contribution to journalReviewResearchpeer-review

  42. Published

    PfEMP1 – a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

    Hviid, Lars & Jensen, Anja Ramstedt, Apr 2015, Advances in Parasitology. Rollinson, D. & Stothard, J. R. (eds.). Vol. 88. p. 51-84 34 p. (Advances in Parasitology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  43. Published

    Investigating the function of Fc -specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting

    Stevenson, L., Huda, P., Jeppesen, A., Laursen, E. T. F., Rowe, J. A., Craig, A., Streicher, W., Barfod, Lea Klingenberg & Hviid, Lars, Jun 2015, In: Cellular Microbiology. 17, 6, p. 819-31 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Rifins, rosetting, and red blood cells

    Wang, Christian William & Hviid, Lars, Jul 2015, In: Trends in Parasitology. 31, 7, p. 285-6 2 p.

    Research output: Contribution to journalJournal articleCommissionedpeer-review

  45. Published

    α2-macroglobulin can crosslink multiple Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) molecules and may facilitate adhesion of parasitized erythrocytes

    Stevenson, L., Laursen, E., Cowan, G. J., Bandoh, B., Barfod, Lea Klingenberg, Cavanagh, D. R., Andersen, G. R. & Hviid, Lars, Jul 2015, In: P L o S Pathogens. 11, 7, p. 1-19 19 p., e1005022.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. 2016
  47. Published

    Immunoglobulin M: restrainer of inflammation and mediator of immune evasion by Plasmodium falciparum malaria

    Pleass, R. J., Moore, S. C., Stevenson, L. & Hviid, Lars, Feb 2016, In: Trends in Parasitology. 32, 2, p. 108-119 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  48. Published

    Orm i toilettet

    Hviid, Lars, Møller-Bisgaard, S. & Kurtzhals, Jørgen, 15 Feb 2016, In: Ugeskrift for Laeger. 178, 7, 1 p., V67428.

    Research output: Contribution to journalJournal articleCommunication

  49. 2017
  50. Published

    Dansk malariaforskning fra spæd begyndelse til international styrkeposition

    Jepsen, M. P. G., Jepsen, S., Kurtzhals, Jørgen & Hviid, Lars, 2017, In: Ugeskrift for Laeger. 179, 20, p. 866-869 V10160756.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Malaria parasite evasion of classical complement pathway attack

    Larsen, M. D., Ditlev, S., Olmos, R. B., Ampomah, P., Ofori, M. F., Garred, Peter & Hviid, Lars, 2017, In: Molecular Immunology. 89, p. 159-159

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  52. Published

    Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

    Lennartz, F., Adams, Y., Bengtsson, A., Olsen, R. W., Turner, L., Ndam, N. T., Ecklu-Mensah, G. D., Moussiliou, A., Ofori, M. F., Gamain, B., Lusingu, J. P., Petersen, J. E. V., Wang, C. W., Nunes-Silva, S., Jespersen, J. S., Lau, C. K. Y., Theander, T. G., Lavstsen, T., Hviid, L., Higgins, M. K. & 1 others, Jensen, Anja Ramstedt, 8 Mar 2017, In: Cell Host & Microbe. 21, 3, p. 403-414 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

    Payne, R. O., Silk, S. E., Elias, S. C., Miura, K., Diouf, A., Galaway, F., de Graaf, H., Brendish, N. J., Poulton, I. D., Griffiths, O. J., Edwards, N. J., Jin, J., Labbé, G. M., Alanine, D. G., Siani, L., Di Marco, S., Roberts, R., Green, N., Berrie, E., Ishizuka, A. S. & 22 others, Nielsen, C. M., Bardelli, M., Partey, Frederica Dedo, Ofori, M. F., Barfod, Lea Klingenberg, Wambua, J., Murungi, L. M., Osier, F. H., Biswas, S., McCarthy, J. S., Minassian, A. M., Ashfield, R., Viebig, N. K., Nugent, F. L., Douglas, A. D., Vekemans, J., Wright, G. J., Faust, S. N., Hill, A. V., Long, C. A., Lawrie, A. M. & Draper, S. J., Nov 2017, In: JCI insight. 2, 21, 19 p., e96381.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 2018
  55. Published

    Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes

    Ecklu-Mensah, G., Olsen, Rebecca Wendelboe, Bengtsson, A., Ofori, M. F., Hviid, Lars, Jensen, Anja Ramstedt & Adams, Yvonne, 2018, In: PLoS ONE. 13, 10, 12 p., e0204177.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Etiology of placental Plasmodium falciparum malaria in African women

    Ofori, M. F., Lamptey, H., Dickson, E. K., Kyei-Baafour, E. & Hviid, Lars, 2018, In: The Journal of Infectious Diseases. 218, 2, p. 277-281 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    IgG responses to the Plasmodium falciparum antigen VAR2CSA in Colombia are restricted to pregnancy and are not induced by exposure to Plasmodium vivax

    Lopez-Perez, Mary, Larsen, M. D., Bayarri-Olmos, R., Ampomah, P., Stevenson, L., Arévalo-Herrera, M., Herrera, S. & Hviid, Lars, 2018, In: Infection and Immunity. 86, 8, e00136-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria

    Partey, Frederica Dedo, Castberg, F. C., Sarbah, E. W., Silk, S. E., Awandare, G. A., Draper, S. J., Opoku, N., Kweku, M., Ofori, M. F., Hviid, Lars & Barfod, Lea Klingenberg, 2018, In: PLOS ONE. 13, 6, 14 p., e0198371.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Natural and vaccine-induced acquisition of cross-reactive IgG inhibiting ICAM-1-specific binding of a Plasmodium falciparum PfEMP1 subtype associated specifically with cerebral malaria

    Olsen, Rebecca Wendelboe, Ecklu-Mensah, G., Bengtsson, A., Ofori, M. F., Lusingu, J. P. A., Castberg, F. C., Hviid, Lars, Adams, Yvonne & Jensen, Anja Ramstedt, 2018, In: Infection and Immunity. 86, 4, 17 p., e00622-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

    Agerbæk, Mette Ørskov, Bang-Christensen, S. R., Yang, M., Clausen, Thomas Mandel, Pereira, M. A., Sharma, S., Ditlev, S. B., Nielsen, Morten Agertoug, Choudhary, Swati, Gustavsson, Tobias, Sorensen, P. H., Meyer, T., Propper, D., Shamash, J., Theander, Thor Grundtvig, Aicher, A., Daugaard, M., Heeschen, C. & Salanti, Ali, 2018, In: Nature Communications. 9, 1, 13 p., 3279.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation

    Castberg, F. C., Maretty, L., Staalsø, Trine, Hempel, C., Clasen-Linde, E., Hviid, Lars & Kurtzhals, Jørgen, 16 Jan 2018, In: Malaria Journal. 17, 1, 12 p., 34.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    A vaccine targeted specifically to prevent cerebral malaria - is there hope?

    Hviid, Lars, Lavstsen, Thomas & Jensen, Anja Ramstedt, Jul 2018, In: Expert Review of Vaccines. 17, 7, p. 565-567 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

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