VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes. / Magistrado, Pamela; Salanti, Ali; Tuikue Ndam, Nicaise G; Mwakalinga, Steven B; Resende, Mafalda; Dahlbäck, Madeleine; Hviid, Lars; Lusingu, John; Theander, Thor G; Nielsen, Morten A.

In: Journal of Infectious Diseases, 2008.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Magistrado, P, Salanti, A, Tuikue Ndam, NG, Mwakalinga, SB, Resende, M, Dahlbäck, M, Hviid, L, Lusingu, J, Theander, TG & Nielsen, MA 2008, 'VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes', Journal of Infectious Diseases. https://doi.org/10.1086/591502

APA

Magistrado, P., Salanti, A., Tuikue Ndam, N. G., Mwakalinga, S. B., Resende, M., Dahlbäck, M., Hviid, L., Lusingu, J., Theander, T. G., & Nielsen, M. A. (2008). VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes. Journal of Infectious Diseases. https://doi.org/10.1086/591502

Vancouver

Magistrado P, Salanti A, Tuikue Ndam NG, Mwakalinga SB, Resende M, Dahlbäck M et al. VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes. Journal of Infectious Diseases. 2008. https://doi.org/10.1086/591502

Author

Magistrado, Pamela ; Salanti, Ali ; Tuikue Ndam, Nicaise G ; Mwakalinga, Steven B ; Resende, Mafalda ; Dahlbäck, Madeleine ; Hviid, Lars ; Lusingu, John ; Theander, Thor G ; Nielsen, Morten A. / VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes. In: Journal of Infectious Diseases. 2008.

Bibtex

@article{7e1de700790111dd81b0000ea68e967b,
title = "VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes",
abstract = "Malaria remains a major threat, in sub-Saharan Africa primarily, and the most deadly infections are those with Plasmodium falciparum. Pregnancy-associated malaria is a clinically important complication of infection; it results from a unique interaction between proteoglycans in the placental intervillous space and parasite antigens. Both placental and chondroitin sulphate A-selected parasites have high-level transcripts of a unique var gene named var2csa. However, VAR2CSA has not been consistently found by proteomic analysis of placental parasites. Contrary to this, we found VAR2CSA expressed on the surface of infected erythrocytes from placenta. Importantly, this was achieved with cross-reactive antibodies against VAR2CSA.",
author = "Pamela Magistrado and Ali Salanti and {Tuikue Ndam}, {Nicaise G} and Mwakalinga, {Steven B} and Mafalda Resende and Madeleine Dahlb{\"a}ck and Lars Hviid and John Lusingu and Theander, {Thor G} and Nielsen, {Morten A}",
year = "2008",
doi = "10.1086/591502",
language = "English",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes

AU - Magistrado, Pamela

AU - Salanti, Ali

AU - Tuikue Ndam, Nicaise G

AU - Mwakalinga, Steven B

AU - Resende, Mafalda

AU - Dahlbäck, Madeleine

AU - Hviid, Lars

AU - Lusingu, John

AU - Theander, Thor G

AU - Nielsen, Morten A

PY - 2008

Y1 - 2008

N2 - Malaria remains a major threat, in sub-Saharan Africa primarily, and the most deadly infections are those with Plasmodium falciparum. Pregnancy-associated malaria is a clinically important complication of infection; it results from a unique interaction between proteoglycans in the placental intervillous space and parasite antigens. Both placental and chondroitin sulphate A-selected parasites have high-level transcripts of a unique var gene named var2csa. However, VAR2CSA has not been consistently found by proteomic analysis of placental parasites. Contrary to this, we found VAR2CSA expressed on the surface of infected erythrocytes from placenta. Importantly, this was achieved with cross-reactive antibodies against VAR2CSA.

AB - Malaria remains a major threat, in sub-Saharan Africa primarily, and the most deadly infections are those with Plasmodium falciparum. Pregnancy-associated malaria is a clinically important complication of infection; it results from a unique interaction between proteoglycans in the placental intervillous space and parasite antigens. Both placental and chondroitin sulphate A-selected parasites have high-level transcripts of a unique var gene named var2csa. However, VAR2CSA has not been consistently found by proteomic analysis of placental parasites. Contrary to this, we found VAR2CSA expressed on the surface of infected erythrocytes from placenta. Importantly, this was achieved with cross-reactive antibodies against VAR2CSA.

U2 - 10.1086/591502

DO - 10.1086/591502

M3 - Journal article

C2 - 18700835

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

ER -

ID: 5834256