Premetastatic niches, exosomes and circulating tumor cells: Early mechanisms of tumor dissemination and the relation to surgery

Research output: Contribution to journal › Review › Research › peer-review

Standard

Premetastatic niches, exosomes and circulating tumor cells : Early mechanisms of tumor dissemination and the relation to surgery. / Raskov, Hans; Orhan, Adile; Salanti, Ali; Gögenur, Ismail.

In: International Journal of Cancer, Vol. 146, No. 12, 2020, p. 3244-3255.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Raskov, H, Orhan, A, Salanti, A & Gögenur, I 2020, 'Premetastatic niches, exosomes and circulating tumor cells: Early mechanisms of tumor dissemination and the relation to surgery', International Journal of Cancer, vol. 146, no. 12, pp. 3244-3255. https://doi.org/10.1002/ijc.32820

APA

Raskov, H., Orhan, A., Salanti, A., & Gögenur, I. (2020). Premetastatic niches, exosomes and circulating tumor cells: Early mechanisms of tumor dissemination and the relation to surgery. International Journal of Cancer, 146(12), 3244-3255. https://doi.org/10.1002/ijc.32820

Vancouver

Raskov H, Orhan A, Salanti A, Gögenur I. Premetastatic niches, exosomes and circulating tumor cells: Early mechanisms of tumor dissemination and the relation to surgery. International Journal of Cancer. 2020;146(12):3244-3255. https://doi.org/10.1002/ijc.32820

Author

Raskov, Hans ; Orhan, Adile ; Salanti, Ali ; Gögenur, Ismail. / Premetastatic niches, exosomes and circulating tumor cells : Early mechanisms of tumor dissemination and the relation to surgery. In: International Journal of Cancer. 2020 ; Vol. 146, No. 12. pp. 3244-3255.

Bibtex

@article{c5c4ebb40c044c58b29e5513d580446a,
title = "Premetastatic niches, exosomes and circulating tumor cells: Early mechanisms of tumor dissemination and the relation to surgery",
abstract = "The physiological stress response to surgery promotes wound healing and functional recovery and includes the activation of neural, inflammatory and proangiogenic signaling pathways. Paradoxically, the same pathways also promote metastatic spread and growth of residual cancer. Human and animal studies show that cancer surgery can increase survival, migration and proliferation of residual tumor cells. To secure the survival and growth of disseminated tumor cells, the formation of premetastatic niches in target organs involves a complex interplay between microenvironment, immune system, circulating tumor cells, as well as chemical mediators and exosomes secreted by the primary tumor. This review describes the current understanding of the early mechanisms of dissemination, as well as how surgery may facilitate disease progression.",
keywords = "circulating tumor cells, exosomes, metastasis, premetastatic niche, surgical stress response",
author = "Hans Raskov and Adile Orhan and Ali Salanti and Ismail G{\"o}genur",
year = "2020",
doi = "10.1002/ijc.32820",
language = "English",
volume = "146",
pages = "3244--3255",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "JohnWiley & Sons, Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Premetastatic niches, exosomes and circulating tumor cells

T2 - Early mechanisms of tumor dissemination and the relation to surgery

AU - Raskov, Hans

AU - Orhan, Adile

AU - Salanti, Ali

AU - Gögenur, Ismail

PY - 2020

Y1 - 2020

N2 - The physiological stress response to surgery promotes wound healing and functional recovery and includes the activation of neural, inflammatory and proangiogenic signaling pathways. Paradoxically, the same pathways also promote metastatic spread and growth of residual cancer. Human and animal studies show that cancer surgery can increase survival, migration and proliferation of residual tumor cells. To secure the survival and growth of disseminated tumor cells, the formation of premetastatic niches in target organs involves a complex interplay between microenvironment, immune system, circulating tumor cells, as well as chemical mediators and exosomes secreted by the primary tumor. This review describes the current understanding of the early mechanisms of dissemination, as well as how surgery may facilitate disease progression.

AB - The physiological stress response to surgery promotes wound healing and functional recovery and includes the activation of neural, inflammatory and proangiogenic signaling pathways. Paradoxically, the same pathways also promote metastatic spread and growth of residual cancer. Human and animal studies show that cancer surgery can increase survival, migration and proliferation of residual tumor cells. To secure the survival and growth of disseminated tumor cells, the formation of premetastatic niches in target organs involves a complex interplay between microenvironment, immune system, circulating tumor cells, as well as chemical mediators and exosomes secreted by the primary tumor. This review describes the current understanding of the early mechanisms of dissemination, as well as how surgery may facilitate disease progression.

KW - circulating tumor cells

KW - exosomes

KW - metastasis

KW - premetastatic niche

KW - surgical stress response

U2 - 10.1002/ijc.32820

DO - 10.1002/ijc.32820

M3 - Review

C2 - 31808150

AN - SCOPUS:85078617549

VL - 146

SP - 3244

EP - 3255

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 12

ER -

ID: 235786076