PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity
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PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity. / Hviid, Lars; Jensen, Anja R.; Deitsch, Kirk W.
Advances in Parasitology. Academic Press, 2024. (Advances in Parasitology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity
AU - Hviid, Lars
AU - Jensen, Anja R.
AU - Deitsch, Kirk W.
N1 - Publisher Copyright: © 2024
PY - 2024
Y1 - 2024
N2 - The most severe form of malaria, caused by infection with Plasmodium falciparum parasites, continues to be an important cause of human suffering and poverty. The P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens, which mediates the adhesion of infected erythrocytes to the vascular endothelium in various tissues and organs, is a central component of the pathogenesis of the disease and a key target of the acquired immune response to malaria. Much new knowledge has accumulated since we published a systematic overview of the PfEMP1 family almost ten years ago. In this chapter, we therefore aim to summarize research progress since 2015 on the structure, function, regulation etc. of this key protein family of arguably the most important human parasite. Recent insights regarding PfEMP1-specific immune responses and PfEMP1-specific vaccination against malaria, as well as an outlook for the coming years are also covered.
AB - The most severe form of malaria, caused by infection with Plasmodium falciparum parasites, continues to be an important cause of human suffering and poverty. The P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens, which mediates the adhesion of infected erythrocytes to the vascular endothelium in various tissues and organs, is a central component of the pathogenesis of the disease and a key target of the acquired immune response to malaria. Much new knowledge has accumulated since we published a systematic overview of the PfEMP1 family almost ten years ago. In this chapter, we therefore aim to summarize research progress since 2015 on the structure, function, regulation etc. of this key protein family of arguably the most important human parasite. Recent insights regarding PfEMP1-specific immune responses and PfEMP1-specific vaccination against malaria, as well as an outlook for the coming years are also covered.
KW - Immunity
KW - Malaria
KW - Pathogenesis
KW - PfEMP1
KW - Plasmodium falciparum
KW - Structure/function
KW - Vaccine
KW - var genes
UR - http://www.scopus.com/inward/record.url?scp=85188725553&partnerID=8YFLogxK
U2 - 10.1016/bs.apar.2024.02.001
DO - 10.1016/bs.apar.2024.02.001
M3 - Book chapter
AN - SCOPUS:85188725553
T3 - Advances in Parasitology
BT - Advances in Parasitology
PB - Academic Press
ER -
ID: 388045147