High level of var2csa transcription by Plasmodium falciparum isolated from the placenta
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High level of var2csa transcription by Plasmodium falciparum isolated from the placenta. / Tuikue Ndam, Nicaise G; Salanti, Ali; Bertin, Gwladys; Dahlbäck, Madeleine; Fievet, Nadine; Turner, Louise; Gaye, Alioune; Theander, Thor; Deloron, Philippe.
In: Journal of Infectious Diseases, Vol. 192, No. 2, 2005, p. 331-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - High level of var2csa transcription by Plasmodium falciparum isolated from the placenta
AU - Tuikue Ndam, Nicaise G
AU - Salanti, Ali
AU - Bertin, Gwladys
AU - Dahlbäck, Madeleine
AU - Fievet, Nadine
AU - Turner, Louise
AU - Gaye, Alioune
AU - Theander, Thor
AU - Deloron, Philippe
N1 - Keywords: Animals; Antigens, Protozoan; Base Sequence; Chondroitin Sulfates; DNA Primers; Female; Humans; Malaria, Falciparum; Placenta; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Infectious; Senegal; Transcription, Genetic; Variation (Genetics)
PY - 2005
Y1 - 2005
N2 - Plasmodium falciparum parasites that bind to chondroitin sulphate A (CSA) express unique variant surface antigens that are involved in the placental sequestration that precipitates pregnancy-associated malaria (PAM). Two var gene subfamilies, var1csa and var2csa, have been associated with CSA binding. We show here that placental P. falciparum isolates highly transcribed var2csa but not var1csa. var2csa was not transcribed or was only minimally transcribed by parasites isolated from nonpregnant women. Placental parasites that effectively bound to placental chondroitin sulphate proteoglycans transcribed higher levels of var2csa. In pregnant women, levels of var2csa transcription and plasma anti-VAR2CSA immunoglobulin G were associated. These findings support the idea that VAR2CSA plays a crucial role in PAM and strengthen the rationale for the development of VAR2CSA-based vaccines.
AB - Plasmodium falciparum parasites that bind to chondroitin sulphate A (CSA) express unique variant surface antigens that are involved in the placental sequestration that precipitates pregnancy-associated malaria (PAM). Two var gene subfamilies, var1csa and var2csa, have been associated with CSA binding. We show here that placental P. falciparum isolates highly transcribed var2csa but not var1csa. var2csa was not transcribed or was only minimally transcribed by parasites isolated from nonpregnant women. Placental parasites that effectively bound to placental chondroitin sulphate proteoglycans transcribed higher levels of var2csa. In pregnant women, levels of var2csa transcription and plasma anti-VAR2CSA immunoglobulin G were associated. These findings support the idea that VAR2CSA plays a crucial role in PAM and strengthen the rationale for the development of VAR2CSA-based vaccines.
U2 - 10.1086/430933
DO - 10.1086/430933
M3 - Journal article
C2 - 15962229
VL - 192
SP - 331
EP - 335
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 2
ER -
ID: 6765285