Fighting cancer using an oncofetal glycosaminoglycan-binding protein from malaria parasites
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Fighting cancer using an oncofetal glycosaminoglycan-binding protein from malaria parasites. / Agerbæk, Mette; Bang-Christensen, Sara; Salanti, Ali.
In: Trends in Parasitology, Vol. 35, No. 3, 2019, p. 178-181.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Fighting cancer using an oncofetal glycosaminoglycan-binding protein from malaria parasites
AU - Agerbæk, Mette
AU - Bang-Christensen, Sara
AU - Salanti, Ali
PY - 2019
Y1 - 2019
N2 - Malaria research has led to the discovery of oncofetal chondroitin sulfate, which appears to be shared between placental trophoblasts and cancer cells and can be detected by the evolutionary refined malaria protein VAR2CSA. Interestingly, using recombinant VAR2CSA to target oncofetal chondroitin sulfate shows promise for novel cancer diagnostics and therapeutics.
AB - Malaria research has led to the discovery of oncofetal chondroitin sulfate, which appears to be shared between placental trophoblasts and cancer cells and can be detected by the evolutionary refined malaria protein VAR2CSA. Interestingly, using recombinant VAR2CSA to target oncofetal chondroitin sulfate shows promise for novel cancer diagnostics and therapeutics.
KW - cancer
KW - oncofetal chondroitin sulfate
KW - placental malaria
KW - VAR2CSA
U2 - 10.1016/j.pt.2018.11.004
DO - 10.1016/j.pt.2018.11.004
M3 - Journal article
C2 - 30551869
AN - SCOPUS:85058018294
VL - 35
SP - 178
EP - 181
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 3
ER -
ID: 212857987