Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study

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Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria : a retrospective case-control study. / Babakhanyan, Anna; Fang, Rui; Wey, Andrew; Salanti, Ali; Sama, Grace; Efundem, Canisia; Leke, Robert J I; Chen, John J; Leke, Rose G F; Taylor, Diane W.

In: Malaria Journal, Vol. 14, 480, 2015.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Babakhanyan, A, Fang, R, Wey, A, Salanti, A, Sama, G, Efundem, C, Leke, RJI, Chen, JJ, Leke, RGF & Taylor, DW 2015, 'Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study', Malaria Journal, vol. 14, 480. https://doi.org/10.1186/s12936-015-1023-6

APA

Babakhanyan, A., Fang, R., Wey, A., Salanti, A., Sama, G., Efundem, C., Leke, R. J. I., Chen, J. J., Leke, R. G. F., & Taylor, D. W. (2015). Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study. Malaria Journal, 14, [480]. https://doi.org/10.1186/s12936-015-1023-6

Vancouver

Babakhanyan A, Fang R, Wey A, Salanti A, Sama G, Efundem C et al. Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study. Malaria Journal. 2015;14. 480. https://doi.org/10.1186/s12936-015-1023-6

Author

Babakhanyan, Anna ; Fang, Rui ; Wey, Andrew ; Salanti, Ali ; Sama, Grace ; Efundem, Canisia ; Leke, Robert J I ; Chen, John J ; Leke, Rose G F ; Taylor, Diane W. / Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria : a retrospective case-control study. In: Malaria Journal. 2015 ; Vol. 14.

Bibtex

@article{5b1dc0f6e23c4f1faf47e836e92807c6,
title = "Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study",
abstract = "BACKGROUND: Antibodies (Ab) to VAR2CSA prevent Plasmodium falciparum-infected erythrocytes from sequestrating in the placenta, i.e., prevent placental malaria (PM). The specificity of Ab to VAR2CSA associated with absence of PM is unknown. Accordingly, differences in the specificity of Ab to VAR2CSA were compared between multigravidae with and without PM who had Ab to VAR2CSA.METHODS: In a retrospective case-control study, plasma collected from Cameroonian multigravidae with (n = 96) and without (n = 324) PM were screened in 21 assays that measured antibody levels to full length VAR2CSA (FV2), individual VAR2CSA DBL domains, VAR2CSA domains from different genetic backgrounds (variants), as well as proportion of high avidity Ab to FV2.RESULTS: Multigravidae with and without PM had similar levels of Ab to FV2, the six VAR2CSA DBL domains and different variants, while the proportion of high avidity Ab to FV2 was significantly higher in women without PM at delivery (p = 0.0030) compared to women with PM. In a logistic regression model adjusted for gravidity and age, the percentage of high avidity Ab to FV2 was associated with reduced likelihood of PM in multigravidae. A 5 % increase in proportion of high avidity Ab to FV2 was associated with a nearly 15 % lower likelihood of PM.CONCLUSION: Ab avidity to FV2 may be an important indicator of immunity to PM.",
author = "Anna Babakhanyan and Rui Fang and Andrew Wey and Ali Salanti and Grace Sama and Canisia Efundem and Leke, {Robert J I} and Chen, {John J} and Leke, {Rose G F} and Taylor, {Diane W}",
year = "2015",
doi = "10.1186/s12936-015-1023-6",
language = "English",
volume = "14",
journal = "Malaria Journal",
issn = "1475-2875",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria

T2 - a retrospective case-control study

AU - Babakhanyan, Anna

AU - Fang, Rui

AU - Wey, Andrew

AU - Salanti, Ali

AU - Sama, Grace

AU - Efundem, Canisia

AU - Leke, Robert J I

AU - Chen, John J

AU - Leke, Rose G F

AU - Taylor, Diane W

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Antibodies (Ab) to VAR2CSA prevent Plasmodium falciparum-infected erythrocytes from sequestrating in the placenta, i.e., prevent placental malaria (PM). The specificity of Ab to VAR2CSA associated with absence of PM is unknown. Accordingly, differences in the specificity of Ab to VAR2CSA were compared between multigravidae with and without PM who had Ab to VAR2CSA.METHODS: In a retrospective case-control study, plasma collected from Cameroonian multigravidae with (n = 96) and without (n = 324) PM were screened in 21 assays that measured antibody levels to full length VAR2CSA (FV2), individual VAR2CSA DBL domains, VAR2CSA domains from different genetic backgrounds (variants), as well as proportion of high avidity Ab to FV2.RESULTS: Multigravidae with and without PM had similar levels of Ab to FV2, the six VAR2CSA DBL domains and different variants, while the proportion of high avidity Ab to FV2 was significantly higher in women without PM at delivery (p = 0.0030) compared to women with PM. In a logistic regression model adjusted for gravidity and age, the percentage of high avidity Ab to FV2 was associated with reduced likelihood of PM in multigravidae. A 5 % increase in proportion of high avidity Ab to FV2 was associated with a nearly 15 % lower likelihood of PM.CONCLUSION: Ab avidity to FV2 may be an important indicator of immunity to PM.

AB - BACKGROUND: Antibodies (Ab) to VAR2CSA prevent Plasmodium falciparum-infected erythrocytes from sequestrating in the placenta, i.e., prevent placental malaria (PM). The specificity of Ab to VAR2CSA associated with absence of PM is unknown. Accordingly, differences in the specificity of Ab to VAR2CSA were compared between multigravidae with and without PM who had Ab to VAR2CSA.METHODS: In a retrospective case-control study, plasma collected from Cameroonian multigravidae with (n = 96) and without (n = 324) PM were screened in 21 assays that measured antibody levels to full length VAR2CSA (FV2), individual VAR2CSA DBL domains, VAR2CSA domains from different genetic backgrounds (variants), as well as proportion of high avidity Ab to FV2.RESULTS: Multigravidae with and without PM had similar levels of Ab to FV2, the six VAR2CSA DBL domains and different variants, while the proportion of high avidity Ab to FV2 was significantly higher in women without PM at delivery (p = 0.0030) compared to women with PM. In a logistic regression model adjusted for gravidity and age, the percentage of high avidity Ab to FV2 was associated with reduced likelihood of PM in multigravidae. A 5 % increase in proportion of high avidity Ab to FV2 was associated with a nearly 15 % lower likelihood of PM.CONCLUSION: Ab avidity to FV2 may be an important indicator of immunity to PM.

U2 - 10.1186/s12936-015-1023-6

DO - 10.1186/s12936-015-1023-6

M3 - Journal article

C2 - 26626275

VL - 14

JO - Malaria Journal

JF - Malaria Journal

SN - 1475-2875

M1 - 480

ER -

ID: 150273836