Antibody mediated activation of natural killer cells in malaria exposed pregnant women

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Antibody mediated activation of natural killer cells in malaria exposed pregnant women. / Damelang, Timon; Aitken, Elizabeth H; Hasang, Wina; Lopez, Ester; Killian, Martin; Unger, Holger W; Salanti, Ali; Shub, Alexis; McCarthy, Elizabeth; Kedzierska, Katherine; Lappas, Martha; Kent, Stephen J; Rogerson, Stephen J; Chung, Amy W.

In: Scientific Reports, Vol. 11, 4130, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Damelang, T, Aitken, EH, Hasang, W, Lopez, E, Killian, M, Unger, HW, Salanti, A, Shub, A, McCarthy, E, Kedzierska, K, Lappas, M, Kent, SJ, Rogerson, SJ & Chung, AW 2021, 'Antibody mediated activation of natural killer cells in malaria exposed pregnant women', Scientific Reports, vol. 11, 4130. https://doi.org/10.1038/s41598-021-83093-4

APA

Damelang, T., Aitken, E. H., Hasang, W., Lopez, E., Killian, M., Unger, H. W., Salanti, A., Shub, A., McCarthy, E., Kedzierska, K., Lappas, M., Kent, S. J., Rogerson, S. J., & Chung, A. W. (2021). Antibody mediated activation of natural killer cells in malaria exposed pregnant women. Scientific Reports, 11, [4130]. https://doi.org/10.1038/s41598-021-83093-4

Vancouver

Damelang T, Aitken EH, Hasang W, Lopez E, Killian M, Unger HW et al. Antibody mediated activation of natural killer cells in malaria exposed pregnant women. Scientific Reports. 2021;11. 4130. https://doi.org/10.1038/s41598-021-83093-4

Author

Damelang, Timon ; Aitken, Elizabeth H ; Hasang, Wina ; Lopez, Ester ; Killian, Martin ; Unger, Holger W ; Salanti, Ali ; Shub, Alexis ; McCarthy, Elizabeth ; Kedzierska, Katherine ; Lappas, Martha ; Kent, Stephen J ; Rogerson, Stephen J ; Chung, Amy W. / Antibody mediated activation of natural killer cells in malaria exposed pregnant women. In: Scientific Reports. 2021 ; Vol. 11.

Bibtex

@article{aa81a0164aef4a81900c64775a7310d9,
title = "Antibody mediated activation of natural killer cells in malaria exposed pregnant women",
abstract = "Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated by the composition of immunoglobulin G (IgG) Fc N-linked glycans. However, a role for antibody-mediated natural killer (NK) cells activation or Fc N-linked glycans in pregnant women with malaria has not yet been established. Herein, we studied the capacity of IgG antibodies from pregnant women, with placental malaria or non-placental malaria, to induce NK cell activation in response to placental malaria-associated antigens DBL2 and DBL3. Antibody-mediated NK cell activation was observed in pregnant women with malaria, but no differences were associated with susceptibility to placental malaria. Elevated anti-inflammatory glycosylation patterns of IgG antibodies were observed in pregnant women with or without malaria infection, which were not seen in healthy non-pregnant controls. This suggests that pregnancy-associated anti-inflammatory Fc N-linked glycans may dampen the antibody-mediated activation of NK cells in pregnant women with malaria infection. Overall, although anti-inflammatory glycans and antibody-dependent NK cell activation were detected in pregnant women with malaria, a definitive role for these antibody features in protecting against placental malaria remains to be proven.",
author = "Timon Damelang and Aitken, {Elizabeth H} and Wina Hasang and Ester Lopez and Martin Killian and Unger, {Holger W} and Ali Salanti and Alexis Shub and Elizabeth McCarthy and Katherine Kedzierska and Martha Lappas and Kent, {Stephen J} and Rogerson, {Stephen J} and Chung, {Amy W}",
year = "2021",
doi = "10.1038/s41598-021-83093-4",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Antibody mediated activation of natural killer cells in malaria exposed pregnant women

AU - Damelang, Timon

AU - Aitken, Elizabeth H

AU - Hasang, Wina

AU - Lopez, Ester

AU - Killian, Martin

AU - Unger, Holger W

AU - Salanti, Ali

AU - Shub, Alexis

AU - McCarthy, Elizabeth

AU - Kedzierska, Katherine

AU - Lappas, Martha

AU - Kent, Stephen J

AU - Rogerson, Stephen J

AU - Chung, Amy W

PY - 2021

Y1 - 2021

N2 - Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated by the composition of immunoglobulin G (IgG) Fc N-linked glycans. However, a role for antibody-mediated natural killer (NK) cells activation or Fc N-linked glycans in pregnant women with malaria has not yet been established. Herein, we studied the capacity of IgG antibodies from pregnant women, with placental malaria or non-placental malaria, to induce NK cell activation in response to placental malaria-associated antigens DBL2 and DBL3. Antibody-mediated NK cell activation was observed in pregnant women with malaria, but no differences were associated with susceptibility to placental malaria. Elevated anti-inflammatory glycosylation patterns of IgG antibodies were observed in pregnant women with or without malaria infection, which were not seen in healthy non-pregnant controls. This suggests that pregnancy-associated anti-inflammatory Fc N-linked glycans may dampen the antibody-mediated activation of NK cells in pregnant women with malaria infection. Overall, although anti-inflammatory glycans and antibody-dependent NK cell activation were detected in pregnant women with malaria, a definitive role for these antibody features in protecting against placental malaria remains to be proven.

AB - Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated by the composition of immunoglobulin G (IgG) Fc N-linked glycans. However, a role for antibody-mediated natural killer (NK) cells activation or Fc N-linked glycans in pregnant women with malaria has not yet been established. Herein, we studied the capacity of IgG antibodies from pregnant women, with placental malaria or non-placental malaria, to induce NK cell activation in response to placental malaria-associated antigens DBL2 and DBL3. Antibody-mediated NK cell activation was observed in pregnant women with malaria, but no differences were associated with susceptibility to placental malaria. Elevated anti-inflammatory glycosylation patterns of IgG antibodies were observed in pregnant women with or without malaria infection, which were not seen in healthy non-pregnant controls. This suggests that pregnancy-associated anti-inflammatory Fc N-linked glycans may dampen the antibody-mediated activation of NK cells in pregnant women with malaria infection. Overall, although anti-inflammatory glycans and antibody-dependent NK cell activation were detected in pregnant women with malaria, a definitive role for these antibody features in protecting against placental malaria remains to be proven.

U2 - 10.1038/s41598-021-83093-4

DO - 10.1038/s41598-021-83093-4

M3 - Journal article

C2 - 33602987

VL - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 4130

ER -

ID: 257138435