Reduced birth weight caused by sextuple drug resistant Plasmodium falciparum infection in early second trimester

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Reduced birth weight caused by sextuple drug resistant Plasmodium falciparum infection in early second trimester. / Hansson, Helle; Minja, Daniel T R; Moeller, Sofie L; Lusingu, John P A; Bygbjerg, Ib C; Yde, Anna-Mathilde; Jensen, Rasmus W; Nag, Sidsel; Msemo, Omari A; Theander, Thor G; Alifrangis, Michael; Schmiegelow, Christentze.

In: The Journal of Infectious Diseases, Vol. 224, No. 9, 2021, p. 1605–1613.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansson, H, Minja, DTR, Moeller, SL, Lusingu, JPA, Bygbjerg, IC, Yde, A-M, Jensen, RW, Nag, S, Msemo, OA, Theander, TG, Alifrangis, M & Schmiegelow, C 2021, 'Reduced birth weight caused by sextuple drug resistant Plasmodium falciparum infection in early second trimester', The Journal of Infectious Diseases, vol. 224, no. 9, pp. 1605–1613. https://doi.org/10.1093/infdis/jiab117

APA

Hansson, H., Minja, D. T. R., Moeller, S. L., Lusingu, J. P. A., Bygbjerg, I. C., Yde, A-M., Jensen, R. W., Nag, S., Msemo, O. A., Theander, T. G., Alifrangis, M., & Schmiegelow, C. (2021). Reduced birth weight caused by sextuple drug resistant Plasmodium falciparum infection in early second trimester. The Journal of Infectious Diseases, 224(9), 1605–1613. https://doi.org/10.1093/infdis/jiab117

Vancouver

Hansson H, Minja DTR, Moeller SL, Lusingu JPA, Bygbjerg IC, Yde A-M et al. Reduced birth weight caused by sextuple drug resistant Plasmodium falciparum infection in early second trimester. The Journal of Infectious Diseases. 2021;224(9):1605–1613. https://doi.org/10.1093/infdis/jiab117

Author

Hansson, Helle ; Minja, Daniel T R ; Moeller, Sofie L ; Lusingu, John P A ; Bygbjerg, Ib C ; Yde, Anna-Mathilde ; Jensen, Rasmus W ; Nag, Sidsel ; Msemo, Omari A ; Theander, Thor G ; Alifrangis, Michael ; Schmiegelow, Christentze. / Reduced birth weight caused by sextuple drug resistant Plasmodium falciparum infection in early second trimester. In: The Journal of Infectious Diseases. 2021 ; Vol. 224, No. 9. pp. 1605–1613.

Bibtex

@article{5b1aabf9c52042fb9079094a1a9e95ba,
title = "Reduced birth weight caused by sextuple drug resistant Plasmodium falciparum infection in early second trimester",
abstract = "Mutations in the Plasmodium falciparum genes Pfdhfr and Pfdhps, particularly the sextuple mutant haplotype threatens the antimalarial effectiveness of sulfadoxine-pyrimethamine as intermittent preventive treatment during pregnancy (IPTp). To explore the impact of sextuple mutant haplotype infections on outcome measures after provision of IPTp-SP, we monitored birth outcomes in women followed from prior to conception or from the first trimester until delivery. Women infected with sextuple haplotypes in early 2 nd trimester specifically, delivered newborns with a lower birth weight (-267g, 95% CI -454; -59, p=0·01) compared to women who did not have malaria during pregnancy and women infected with less SP resistant haplotypes (-461g, 95% CI -877; -44, p=0·03). Thus, sextuple haplotype infections seems to impact the effectiveness of SP for IPTp and directly impact birth outcome by lowering birth weight. Close monitoring and targeted malaria control during early pregnancy is therefore crucial to improve birth outcomes.",
author = "Helle Hansson and Minja, {Daniel T R} and Moeller, {Sofie L} and Lusingu, {John P A} and Bygbjerg, {Ib C} and Anna-Mathilde Yde and Jensen, {Rasmus W} and Sidsel Nag and Msemo, {Omari A} and Theander, {Thor G} and Michael Alifrangis and Christentze Schmiegelow",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2021",
doi = "10.1093/infdis/jiab117",
language = "English",
volume = "224",
pages = "1605–1613",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Reduced birth weight caused by sextuple drug resistant Plasmodium falciparum infection in early second trimester

AU - Hansson, Helle

AU - Minja, Daniel T R

AU - Moeller, Sofie L

AU - Lusingu, John P A

AU - Bygbjerg, Ib C

AU - Yde, Anna-Mathilde

AU - Jensen, Rasmus W

AU - Nag, Sidsel

AU - Msemo, Omari A

AU - Theander, Thor G

AU - Alifrangis, Michael

AU - Schmiegelow, Christentze

N1 - © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2021

Y1 - 2021

N2 - Mutations in the Plasmodium falciparum genes Pfdhfr and Pfdhps, particularly the sextuple mutant haplotype threatens the antimalarial effectiveness of sulfadoxine-pyrimethamine as intermittent preventive treatment during pregnancy (IPTp). To explore the impact of sextuple mutant haplotype infections on outcome measures after provision of IPTp-SP, we monitored birth outcomes in women followed from prior to conception or from the first trimester until delivery. Women infected with sextuple haplotypes in early 2 nd trimester specifically, delivered newborns with a lower birth weight (-267g, 95% CI -454; -59, p=0·01) compared to women who did not have malaria during pregnancy and women infected with less SP resistant haplotypes (-461g, 95% CI -877; -44, p=0·03). Thus, sextuple haplotype infections seems to impact the effectiveness of SP for IPTp and directly impact birth outcome by lowering birth weight. Close monitoring and targeted malaria control during early pregnancy is therefore crucial to improve birth outcomes.

AB - Mutations in the Plasmodium falciparum genes Pfdhfr and Pfdhps, particularly the sextuple mutant haplotype threatens the antimalarial effectiveness of sulfadoxine-pyrimethamine as intermittent preventive treatment during pregnancy (IPTp). To explore the impact of sextuple mutant haplotype infections on outcome measures after provision of IPTp-SP, we monitored birth outcomes in women followed from prior to conception or from the first trimester until delivery. Women infected with sextuple haplotypes in early 2 nd trimester specifically, delivered newborns with a lower birth weight (-267g, 95% CI -454; -59, p=0·01) compared to women who did not have malaria during pregnancy and women infected with less SP resistant haplotypes (-461g, 95% CI -877; -44, p=0·03). Thus, sextuple haplotype infections seems to impact the effectiveness of SP for IPTp and directly impact birth outcome by lowering birth weight. Close monitoring and targeted malaria control during early pregnancy is therefore crucial to improve birth outcomes.

U2 - 10.1093/infdis/jiab117

DO - 10.1093/infdis/jiab117

M3 - Journal article

C2 - 33684211

VL - 224

SP - 1605

EP - 1613

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 9

ER -

ID: 257978919