The rapid and spontaneous postpartum clearance of Plasmodium falciparum is related to expulsion of the placenta

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The rapid and spontaneous postpartum clearance of Plasmodium falciparum is related to expulsion of the placenta. / Anabire, Nsoh G; Quintana, Maria Del Pilar; Ofori, Michael F; Hviid, Lars.

In: The Journal of Infectious Diseases, Vol. 228, No. 2, 2023, p. 196-201.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Anabire, NG, Quintana, MDP, Ofori, MF & Hviid, L 2023, 'The rapid and spontaneous postpartum clearance of Plasmodium falciparum is related to expulsion of the placenta', The Journal of Infectious Diseases, vol. 228, no. 2, pp. 196-201. https://doi.org/10.1093/infdis/jiad031

APA

Anabire, N. G., Quintana, M. D. P., Ofori, M. F., & Hviid, L. (2023). The rapid and spontaneous postpartum clearance of Plasmodium falciparum is related to expulsion of the placenta. The Journal of Infectious Diseases, 228(2), 196-201. https://doi.org/10.1093/infdis/jiad031

Vancouver

Anabire NG, Quintana MDP, Ofori MF, Hviid L. The rapid and spontaneous postpartum clearance of Plasmodium falciparum is related to expulsion of the placenta. The Journal of Infectious Diseases. 2023;228(2):196-201. https://doi.org/10.1093/infdis/jiad031

Author

Anabire, Nsoh G ; Quintana, Maria Del Pilar ; Ofori, Michael F ; Hviid, Lars. / The rapid and spontaneous postpartum clearance of Plasmodium falciparum is related to expulsion of the placenta. In: The Journal of Infectious Diseases. 2023 ; Vol. 228, No. 2. pp. 196-201.

Bibtex

@article{561c22d6178f49ef9f90d6c2b5133e22,
title = "The rapid and spontaneous postpartum clearance of Plasmodium falciparum is related to expulsion of the placenta",
abstract = "Parasitemia among pregnant women with protective immunity to Plasmodium falciparum malaria is often dominated by VAR2CSA-positive infected erythrocytes (IEs). VAR2CSA mediates sequestration of IEs in the placenta. We hypothesized that the previously observed spontaneous postpartum clearance of parasitemia in such women is related to the expulsion of the placenta, which removes the sequestration focus of VAR2CSA-positive IEs. We assessed parasitemias and gene transcription before and shortly after delivery in 17 Ghanaian women. The precipitous decline in parasitemia postpartum was accompanied by selective reduction in transcription of the gene encoding VAR2CSA. Our findings provide a mechanistic explanation for the earlier observation.",
keywords = "Female, Pregnancy, Humans, Plasmodium falciparum/genetics, Parasitemia, Ghana, Antigens, Protozoan, Protozoan Proteins, Placenta, Malaria, Falciparum, Erythrocytes, Pregnancy Complications, Parasitic, Postpartum Period, Antibodies, Protozoan",
author = "Anabire, {Nsoh G} and Quintana, {Maria Del Pilar} and Ofori, {Michael F} and Lars Hviid",
note = "{\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",
year = "2023",
doi = "10.1093/infdis/jiad031",
language = "English",
volume = "228",
pages = "196--201",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - The rapid and spontaneous postpartum clearance of Plasmodium falciparum is related to expulsion of the placenta

AU - Anabire, Nsoh G

AU - Quintana, Maria Del Pilar

AU - Ofori, Michael F

AU - Hviid, Lars

N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2023

Y1 - 2023

N2 - Parasitemia among pregnant women with protective immunity to Plasmodium falciparum malaria is often dominated by VAR2CSA-positive infected erythrocytes (IEs). VAR2CSA mediates sequestration of IEs in the placenta. We hypothesized that the previously observed spontaneous postpartum clearance of parasitemia in such women is related to the expulsion of the placenta, which removes the sequestration focus of VAR2CSA-positive IEs. We assessed parasitemias and gene transcription before and shortly after delivery in 17 Ghanaian women. The precipitous decline in parasitemia postpartum was accompanied by selective reduction in transcription of the gene encoding VAR2CSA. Our findings provide a mechanistic explanation for the earlier observation.

AB - Parasitemia among pregnant women with protective immunity to Plasmodium falciparum malaria is often dominated by VAR2CSA-positive infected erythrocytes (IEs). VAR2CSA mediates sequestration of IEs in the placenta. We hypothesized that the previously observed spontaneous postpartum clearance of parasitemia in such women is related to the expulsion of the placenta, which removes the sequestration focus of VAR2CSA-positive IEs. We assessed parasitemias and gene transcription before and shortly after delivery in 17 Ghanaian women. The precipitous decline in parasitemia postpartum was accompanied by selective reduction in transcription of the gene encoding VAR2CSA. Our findings provide a mechanistic explanation for the earlier observation.

KW - Female

KW - Pregnancy

KW - Humans

KW - Plasmodium falciparum/genetics

KW - Parasitemia

KW - Ghana

KW - Antigens, Protozoan

KW - Protozoan Proteins

KW - Placenta

KW - Malaria, Falciparum

KW - Erythrocytes

KW - Pregnancy Complications, Parasitic

KW - Postpartum Period

KW - Antibodies, Protozoan

U2 - 10.1093/infdis/jiad031

DO - 10.1093/infdis/jiad031

M3 - Journal article

C2 - 36740589

VL - 228

SP - 196

EP - 201

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -

ID: 359603324