Prevalence and associated factors of dengue virus circulation in the rural community, Handeni district in Tanga, Tanzania
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Prevalence and associated factors of dengue virus circulation in the rural community, Handeni district in Tanga, Tanzania. / Kajeguka, Debora C; Mponela, Francis M; Mkumbo, Emmanuel; Kaaya, Anna N; Lasway, Daniel; Kaaya, Robert D; Alifrangis, Michael; Elanga-Ndille, Emmanuel; Mmbaga, Blandina T; Kavishe, Reginald.
In: Journal of Tropical Medicine, Vol. 2023, 5576300, 2023, p. 1-9.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Prevalence and associated factors of dengue virus circulation in the rural community, Handeni district in Tanga, Tanzania
AU - Kajeguka, Debora C
AU - Mponela, Francis M
AU - Mkumbo, Emmanuel
AU - Kaaya, Anna N
AU - Lasway, Daniel
AU - Kaaya, Robert D
AU - Alifrangis, Michael
AU - Elanga-Ndille, Emmanuel
AU - Mmbaga, Blandina T
AU - Kavishe, Reginald
N1 - Copyright © 2023 Debora C. Kajeguka et al.
PY - 2023
Y1 - 2023
N2 - Dengue virus is among the most important re-emerging arbovirus that causes global public health attention. Dengue has historically been thought of as an urban disease that frequently occurs in rapidly urbanized settings. However, dengue has become more widespread in rural regions in recent years. Understanding the changing dengue epidemiology in different geographical settings is important for targeted intervention. In Tanzania, dengue fever is not frequently reported because of the poor surveillance infrastructure, underestimation, and a lack of consideration of dengue as a priority. Therefore, the true burden as well as the risk factors for increased transmission has not been fully ascertained, particularly in rural areas. A cross-sectional community-based study was conducted in June 2021, involving a total of 362 participants of all age groups. We investigated the prevalence of acute dengue infection, seroprevalence, and associated factors among the community in three villages of the rural Handeni district. The prevalence of acute dengue infection (based on PCR) was 2.2% (8/362). Dengue-specific IgM and IgG antibodies were detected in 3.3% (12/362) and 5.2% (19/362) of the participants, respectively. Adult participants who were having vegetation around their houses were more likely to be DENV seropositive (AOR = 2.4, CI = 1.88-4.18, p value = 0.05). Children living in houses with garbage pit around their households were less likely to be DENV seropositive (AOR = 0.13, CI = 0.03-0.56, p value <0.01). DENV continues to circulate in rural Tanzania, causes an alarming situation, and necessitates prompt public health action to enhance vector surveillance and control in rural communities.
AB - Dengue virus is among the most important re-emerging arbovirus that causes global public health attention. Dengue has historically been thought of as an urban disease that frequently occurs in rapidly urbanized settings. However, dengue has become more widespread in rural regions in recent years. Understanding the changing dengue epidemiology in different geographical settings is important for targeted intervention. In Tanzania, dengue fever is not frequently reported because of the poor surveillance infrastructure, underestimation, and a lack of consideration of dengue as a priority. Therefore, the true burden as well as the risk factors for increased transmission has not been fully ascertained, particularly in rural areas. A cross-sectional community-based study was conducted in June 2021, involving a total of 362 participants of all age groups. We investigated the prevalence of acute dengue infection, seroprevalence, and associated factors among the community in three villages of the rural Handeni district. The prevalence of acute dengue infection (based on PCR) was 2.2% (8/362). Dengue-specific IgM and IgG antibodies were detected in 3.3% (12/362) and 5.2% (19/362) of the participants, respectively. Adult participants who were having vegetation around their houses were more likely to be DENV seropositive (AOR = 2.4, CI = 1.88-4.18, p value = 0.05). Children living in houses with garbage pit around their households were less likely to be DENV seropositive (AOR = 0.13, CI = 0.03-0.56, p value <0.01). DENV continues to circulate in rural Tanzania, causes an alarming situation, and necessitates prompt public health action to enhance vector surveillance and control in rural communities.
U2 - 10.1155/2023/5576300
DO - 10.1155/2023/5576300
M3 - Journal article
C2 - 38028027
VL - 2023
SP - 1
EP - 9
JO - Journal of Tropical Medicine
JF - Journal of Tropical Medicine
SN - 1687-9686
M1 - 5576300
ER -
ID: 374742941