Oxidative stress in malaria and artemisinin combination therapy: Pros and Cons
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Oxidative stress in malaria and artemisinin combination therapy : Pros and Cons. / Kavishe, Reginald A.; Koenderink, Jan B.; Alifrangis, Michael.
In: FEBS Journal, Vol. 284, No. 16, 2017, p. 2579-2591.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Oxidative stress in malaria and artemisinin combination therapy
T2 - Pros and Cons
AU - Kavishe, Reginald A.
AU - Koenderink, Jan B.
AU - Alifrangis, Michael
PY - 2017
Y1 - 2017
N2 - Artemisinin-based combination therapy (ACT) has been adopted as a strategy to mitigate multidrug resistance to antimalarial monotherapies. ACT combines the rapid and effective but rather short plasma half-life antimalarial action of an artemisinin derivative with a longer acting partner drug. Although the exact mechanisms of action of artemisinins are not well understood, several studies have proposed multiple cellular targets of artemisinins with involvement of reactive oxygen species (ROS). Most of the currently used ACT partner drugs are also known to involve ROS production in their mechanisms of action. This review gives a brief account of the oxidative stress and redox systems in malaria and discusses the context of antimalarial effectiveness of different ACTs compared with monotherapies of the partner drugs. A final account on the Pros and Cons of ACT as a strategy is discussed.
AB - Artemisinin-based combination therapy (ACT) has been adopted as a strategy to mitigate multidrug resistance to antimalarial monotherapies. ACT combines the rapid and effective but rather short plasma half-life antimalarial action of an artemisinin derivative with a longer acting partner drug. Although the exact mechanisms of action of artemisinins are not well understood, several studies have proposed multiple cellular targets of artemisinins with involvement of reactive oxygen species (ROS). Most of the currently used ACT partner drugs are also known to involve ROS production in their mechanisms of action. This review gives a brief account of the oxidative stress and redox systems in malaria and discusses the context of antimalarial effectiveness of different ACTs compared with monotherapies of the partner drugs. A final account on the Pros and Cons of ACT as a strategy is discussed.
KW - antimalarial
KW - artemisinin
KW - artemisinin-based combination therapy
KW - drug resistance
KW - malaria
KW - oxidative stress
KW - Plasmodium falciparum
KW - reactive oxygen species
U2 - 10.1111/febs.14097
DO - 10.1111/febs.14097
M3 - Review
C2 - 28467668
AN - SCOPUS:85019950581
VL - 284
SP - 2579
EP - 2591
JO - F E B S Journal
JF - F E B S Journal
SN - 1742-464X
IS - 16
ER -
ID: 183609731