Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies. / Fasanya, Adebimpe; Mohammed, Nurat; Saleh, Bandar Hasan; Tijani, Muyideen Kolapo; Teleka, Alexandra; Quintana, Maria Del Pilar; Hviid, Lars; Persson, Kristina E M.
In: Frontiers in Cellular and Infection Microbiology, Vol. 13, 1130186, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies
AU - Fasanya, Adebimpe
AU - Mohammed, Nurat
AU - Saleh, Bandar Hasan
AU - Tijani, Muyideen Kolapo
AU - Teleka, Alexandra
AU - Quintana, Maria Del Pilar
AU - Hviid, Lars
AU - Persson, Kristina E M
N1 - Copyright © 2023 Fasanya, Mohammed, Saleh, Tijani, Teleka, Quintana, Hviid and Persson.
PY - 2023
Y1 - 2023
N2 - Anemia is a common malaria-associated complication in pregnant women in endemic regions. Phosphatidylserine (PS) is exposed to the immune system during the massive destruction of red blood cells (RBCs) that accompany malaria, and antibodies against PS have been linked to anemia through destruction of uninfected RBCs. We determined levels of anti-PS IgG antibodies in pregnant women in Ibadan, Nigeria and correlated them to parameters of importance in development of anemia and immunity. Anti-PS correlated inversely with Packed Cell Volume (PCV), indicating that the antibodies could contribute to anemia. There was no correlation with anti-VAR2CSA IgG, haptoglobin or parasitemia, indicating that the modulation of anti-PS response is multifactorial in nature. Anti-PS levels were lowest in multigravidae compared to both primigravidae and secundigravidae and correlated inversely with age. In conclusion, lower levels of anti-PS in multigravidae could be beneficial in avoiding anemia.
AB - Anemia is a common malaria-associated complication in pregnant women in endemic regions. Phosphatidylserine (PS) is exposed to the immune system during the massive destruction of red blood cells (RBCs) that accompany malaria, and antibodies against PS have been linked to anemia through destruction of uninfected RBCs. We determined levels of anti-PS IgG antibodies in pregnant women in Ibadan, Nigeria and correlated them to parameters of importance in development of anemia and immunity. Anti-PS correlated inversely with Packed Cell Volume (PCV), indicating that the antibodies could contribute to anemia. There was no correlation with anti-VAR2CSA IgG, haptoglobin or parasitemia, indicating that the modulation of anti-PS response is multifactorial in nature. Anti-PS levels were lowest in multigravidae compared to both primigravidae and secundigravidae and correlated inversely with age. In conclusion, lower levels of anti-PS in multigravidae could be beneficial in avoiding anemia.
KW - Humans
KW - Pregnancy
KW - Female
KW - Pregnant Women
KW - Malaria, Falciparum
KW - Nigeria/epidemiology
KW - Phosphatidylserines
KW - Malaria/complications
KW - Anemia/complications
KW - Immunoglobulin G
KW - Plasmodium falciparum
KW - Antigens, Protozoan
KW - Antibodies, Protozoan
U2 - 10.3389/fcimb.2023.1130186
DO - 10.3389/fcimb.2023.1130186
M3 - Journal article
C2 - 37091678
VL - 13
JO - Frontiers in Cellular and Infection Microbiology
JF - Frontiers in Cellular and Infection Microbiology
SN - 2235-2988
M1 - 1130186
ER -
ID: 344721021