Morten Agertoug Nielsen
Professor
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First-in-human use of a modular capsid virus-like vaccine platform: An open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2
Smit, M. J., Sander, A. F., Ariaans, M. B. P. A., Fougeroux, C., Heinzel, C., Fendel, R., Esen, M., Kremsner, P. G., Ter Heine, R., Wertheim, H. F., Idorn, M., Paludan, S. R., Underwood, A. P., Binderup, A., Ramirez, S., Bukh, J., Soegaard, M., Erdogan, S. M., Gustavsson, T., Clemmensen, S. & 14 others, , 2023, In: The Lancet Microbe. 4, 3, p. e140-e148Research output: Contribution to journal › Journal article › Research › peer-review
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First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria
Mordmüller, B., Sulyok, M., Egger-Adam, D., Resende, M., de Jongh, W. A., Jensen, M. H., Smedegaard, H. H., Ditlev, S. B., Soegaard, M., Poulsen, L., Dyring, C., Calle, C. L., Knoblich, A., Ibáñez, J., Esen, M., Deloron, P., Ndam, N., Issifou, S., Houard, S., Howard, R. F. & 7 others, , 2019, In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 69, 9, p. 1509-1516 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion blocking antibodies
Khunrae, P., Dahlbäck, M., Nielsen, Morten Agertoug, Andersen, G., Ditlev, S. B., Resende, M., Pinto, V. V., Theander, Thor Grundtvig, Higgins, M. K. & Salanti, Ali, 2010, In: Journal of Molecular Biology. 397, p. 826-834Research output: Contribution to journal › Journal article › Research › peer-review
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Geographical and temporal conservation of antibody recognition of Plasmodium falciparum variant surface antigens
Nielsen, Morten Agertoug, Vestergaard, L. S., Lusingu, J., Kurtzhals, Jørgen, Giha, H. A., Grevstad, B., Goka, B. Q., Lemnge, M. M., Jensen, J. B., Akanmori, B. D., Theander, Thor Grundtvig, Staalsoe, T. & Hviid, Lars, 2004, In: Infection and Immunity. 72, 6, p. 3531-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High efficacy of anti DBL4e-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women
Magistrado, P. A., Minja, D., Doritchamou, J., Ndam, N. T., John, D., Schmiegelow, Christentze, Massougbodji, A., Dahlbäck, M., Ditlev, S. B., Pinto, V. V., Resende, M., Lusingu, J., Theander, Thor Grundtvig, Salanti, Ali & Nielsen, Morten Agertoug, 2011, In: Vaccine. 29, 3, p. 437-43 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-Throughput Testing of Antibody-Dependent Binding Inhibition of Placental Malaria Parasites
Nielsen, Morten Agertoug & Salanti, Ali, 2015, Malaria Vaccines : Methods and Protocols . Humana Press, Vol. 1325. p. 241-53 13 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA
Barfod, Lea Klingenberg, Bernasconi, N. L., Dahlbäck, M., Jarrossay, D., Andersen, P. H., Salanti, Ali, Ofori, M. F., Turner, Louise, Resende, M., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sallusto, F., Lanzavecchia, A. & Hviid, Lars, 2007, In: Molecular Microbiology. 63, 2, p. 335-47 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification and characterization of B-cell epitopes in the DBL4e domain of VAR2CSA
Ditlev, S. B., Nielsen, Morten Agertoug, Resende, M., Agerbæk, Mette Ørskov, Pinto, V. V., Andersen, P. H., Magistrado, P., Lusingu, J., Dahlbäck, M., Theander, Thor Grundtvig & Salanti, Ali, 2012, In: P L o S One. 7, 9, p. e43663Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA
Doritchamou, J., Sabbagh, A., Jespersen, Jakob Schmidt, Renard, E., Salanti, Ali, Nielsen, Morten Agertoug, Deloron, P. & Tuikue Ndam, N., 2015, In: PLOS ONE. 10, 9, 14 p., e0137695.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA
Resende, M., Nielsen, Morten Agertoug, Dahlbäck, M., Ditlev, S. B., Andersen, P., Sander, A. F., Ndam, N. T., Theander, Thor Grundtvig & Salanti, Ali, 2008, In: Malaria Journal. 7, p. 104Research output: Contribution to journal › Journal article › Research › peer-review
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Improving the malaria transmission-blocking activity of a Plasmodium falciparum 48/45 based vaccine antigen by SpyTag/SpyCatcher mediated virus-like display
Singh, S. K., Thrane, Susan, Janitzek, C. M., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Theisen, Michael, Salanti, Ali & Sander, Adam F. , 2017, In: Vaccine. 35, 30, p. 3726-3732 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Induction of adhesion-inhibitory antibodies against placental Plasmodium falciparum parasites by using single domains of VAR2CSA
Nielsen, Morten Agertoug, Pinto, V. V., Resende, M., Dahlbäck, M., Ditlev, S. B., Theander, Thor Grundtvig & Salanti, Ali, 2009, In: Infection and Immunity. 77, 6, p. 2482-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Insecticide-treated bed nets reduce plasma antibody levels and limit the repertoire of antibodies to Plasmodium falciparum variant surface antigens
Askjaer, N., Maxwell, C., Chambo, W., Staalsoe, T., Nielsen, Morten Agertoug, Hviid, Lars, Curtis, C. & Theander, Thor Grundtvig, 2001, In: Clinical and Vaccine Immunology. 8, 6, p. 1289-91 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mannose-binding lectin is a disease modifier in clinical malaria and may function as opsonin for Plasmodium falciparum-infected erythrocytes
Garred, Peter, Nielsen, Morten Agertoug, Kurtzhals, Jørgen, Malhotra, R., Madsen, H. O., Goka, B. Q., Akanmori, B. D., Sim, R. B. & Hviid, Lars, 2003, In: Infection and Immunity. 71, 9, p. 5245-53 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro
Jensen, S., Omarsdottir, S., Bwalya, A. G., Nielsen, Morten Agertoug, Tasdemir, D. & Olafsdottir, E. S., 2012, In: Phytomedicine. 19, 13, p. 1191-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
Fried, M., Avril, M., Chaturvedi, R., Fernandez, P., Lograsso, J., Narum, D., Nielsen, Morten Agertoug, Oleinikov, A. V., Resende, M., Salanti, Ali, Saveria, T., Williamson, K., Dicko, A., Scherf, A., Smith, J. D., Theander, Thor Grundtvig & Duffy, P. E., 2013, In: Infect Immun. 81, 2, p. 487-95 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates
Sander, Adam F. , Salanti, Ali, Lavstsen, Thomas, Nielsen, Morten Agertoug, Magistrado, P., Lusingu, J., Ndam, N. T. & Arnot, D. E., 2009, In: PLoS ONE. 4, 8, p. e6667Research output: Contribution to journal › Journal article › Research › peer-review
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Novel adenovirus encoded virus-like particles displaying the placental malaria associated VAR2CSA antigen
Andersson, A. C., dos Santos Marques Resende, M., Salanti, Ali, Nielsen, Morten Agertoug & Holst, Peter Johannes, 22 Feb 2017, In: Vaccine. 35, 8, p. 1140-1147 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Persistent Plasmodium falciparum Infection in Women With an Intent to Become Pregnant as a Risk Factor for Pregnancy-associated Malaria
Tuikue Ndam, N., Tornyigah, B., Dossou, A. Y., Escriou, G., Nielsen, Morten Agertoug, Salanti, Ali, Issifou, S., Massougbodji, A., Chippaux, J. P. & Deloron, P., 2018, In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 67, 12, p. 1890-1896 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pfs230 and Pfs48/45 fusion proteins elicit strong transmission-blocking antibody responses against Plasmodium falciparum
Singh, S. K., Thrane, Susan, Chourasia, B. K., Teelen, K., Graumans, W., Stoter, R., van Gemert, G., van de Vegte-Bolmer, M. G., Nielsen, Morten Agertoug, Salanti, Ali, Sander, Adam F. , Sauerwein, R. W., Jore, M. M. & Theisen, Michael, 2019, In: Frontiers in Immunology. 10, 1256.Research output: Contribution to journal › Journal article › Research › peer-review
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Placental sequestration of Plasmodium falciparum malaria parasites is mediated by the interaction between VAR2CSA and chondroitin sulfate A on syndecan-1
Ayres Pereira, M., Clausen, Thomas Mandel, Pehrson, Caroline, Mao, Y., Resende, M., Daugaard, M., Riis Kristensen, A., Spliid, C. B., Mathiesen, Line, Knudsen, Lisbeth E., Damm, Peter, Theander, Thor Grundtvig, R Hansson, S., Nielsen, Morten Agertoug & Salanti, Ali, Aug 2016, In: P L o S Pathogens. 12, 8, 26 p., e1005831.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasmodium falciparum Expressing Domain Cassette 5 Type PfEMP1 (DC5-PfEMP1) Bind PECAM1
Berger, S. S., Turner, Louise, Wang, Christian William, Petersen, J. E. V., Kraft, M., Lusingu, J. P. A., Mmbando, B., Marquard, A. M., Bengtsson, D. B. A. C., Hviid, Lars, Nielsen, Morten Agertoug, Theander, Thor Grundtvig & Lavstsen, Thomas, 2013, In: PloS one. 8, 7, p. e69117Research output: Contribution to journal › Journal article › Research › peer-review
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Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women
Sander, A. F., Salanti, Ali, Lavstsen, Thomas, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Leke, R. G. F., Lo, Y. Y., Bobbili, N., Arnot, D. E. & Taylor, D. W., 2011, In: Journal of Infectious Diseases. 203, 11, p. 1679-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pre-clinical and clinical development of the first placental malaria vaccine
Pehrson, Caroline, Salanti, Ali, Theander, Thor Grundtvig & Nielsen, Morten Agertoug, 2017, In: Expert Review of Vaccines. 16, 6, p. 613-624 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preferential transcription of conserved rif genes in two phenotypically distinct Plasmodium falciparum parasite lines
Wang, Christian William, Magistrado, P. A., Nielsen, Morten Agertoug, Theander, Thor Grundtvig & Lavstsen, Thomas, 2009, In: International Journal for Parasitology. 39, 6, p. 655-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Progress and insights toward an effective placental malaria vaccine
Gamain, B., Chêne, A., Viebig, N. K., Tuikue Ndam, N. & Nielsen, Morten Agertoug, 2021, In: Frontiers in Immunology. 12, 634508.Research output: Contribution to journal › Review › Research › peer-review
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Protective antibodies against placental malaria and poor outcomes during pregnancy, Benin
Ndam, N. T., Denoeud-Ndam, L., Doritchamou, J., Viwami, F., Salanti, Ali, Nielsen, Morten Agertoug, Fievet, N., Massougbodji, A., Luty, A. J. F. & Deloron, P., 2015, In: Emerging Infectious Diseases (Print Edition). 21, 5, p. 813-823 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies
Salanti, Ali, Resende, M., Ditlev, S. B., Pinto, V. V., Dahlbäck, M., Andersen, G., Manczak, T., Theander, Thor Grundtvig & Nielsen, Morten Agertoug, 2010, In: Malaria Journal. 9, 1, p. 11Research output: Contribution to journal › Journal article › Research › peer-review
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Severe malaria is associated with parasite binding to endothelial protein C receptor
Turner, Louise, Lavstsen, Thomas, Berger, S. S., Wang, Christian William, Petersen, J. E. V., Avril, M., Brazier, A. J., Freeth, J., Jespersen, Jakob Schmidt, Nielsen, Morten Agertoug, Magistrado, P., Lusingu, J., Smith, J. D., Higgins, M. K. & Theander, Thor Grundtvig, 27 Jun 2013, In: Nature. 498, 7455, p. 502-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Specificity and cross-reactivity of Plasmodium falciparum variant surface antigen-specific antibody responses
Hviid, Lars, Staalsoe, T., Nielsen, Morten Agertoug & Theander, Thor Grundtvig, 2003, In: Infection and Immunity. 71, 4, p. 2296Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria
Clausen, Thomas Mandel, Christoffersen, S., Dahlbäck, M., Langkilde, Annette Eva, Jensen, K. E., Resende, M., Agerbæk, Mette Ørskov, Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Larsen, Sine & Salanti, Ali, 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
Andersen, P., Nielsen, Morten Agertoug, Resende, M., Rask, T. S., Dahlbäck, M., Theander, Thor Grundtvig, Lund, O. & Salanti, Ali, 2008, In: PLoS Pathogens. 4, 2, p. e42Research output: Contribution to journal › Journal article › Research › peer-review
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Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
Salanti, A., Clausen, T. M., Agerbæk, M. Ø., Al Nakouzi, N., Dahlbäck, M., Oo, H. Z., Lee, S., Gustavsson, T., Rich, J. R., Hedberg, B. J., Mao, Y., Barington, L., Pereira, M. A., LoBello, J., Endo, M., Fazli, L., Soden, J., Wang, C. K., Sander, A. F., Dagil, R. & 15 others, , 2015, In: Cancer Cell. 28, 4, p. 500-14 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization
Farzadfard, A., Pedersen, J. N., Meisl, G., Somavarapu, A. K., Alam, P., Goksøyr, L., Nielsen, Morten Agertoug, Sander, Adam F. , Knowles, T. P. J., Pedersen, J. S. & Otzen, D. E., 2022, In: Communications Biology . 5, 1, 123.Research output: Contribution to journal › Journal article › Research › peer-review
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The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine
Nielsen, M. A., dos Santos Marques Resende, M., de Jongh, W. A., Ditlev, S. B., Mordmüller, B., Houard, S., Ndam, N. T., Agerbæk, M. Ø., Jensen, M. H., Massougbodji, A., Issifou, S., Strøbæk, A., Poulsen, L., Leroy, O., Kremsner, P. G., Chippaux, J-P., Luty, A. J. F., Deloron, P., Theander, T. G., Dyring, C. & 1 others, , 2015, In: PloS one. 10, 9, 12 p., e0135406.Research output: Contribution to journal › Journal article › Research › peer-review
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The NTS-DBL2X region of VAR2CSA Induces cross-reactive antibodies that inhibit adhesion of several Plasmodium falciparum isolates to chondroitin sulfate A
Bigey, P., Gnidehou, S., Doritchamou, J., Quiviger, M., Viwami, F., Couturier, A., Salanti, Ali, Nielsen, Morten Agertoug, Scherman, D., Deloron, P. & Tuikue Ndam, N., 2011, In: Journal of Infectious Diseases. 204, 7, p. 1125-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
Agerbæk, Mette Ørskov, Bang-Christensen, S. R., Yang, M., Clausen, Thomas Mandel, Pereira, M. A., Sharma, S., Ditlev, S. B., Nielsen, Morten Agertoug, Choudhary, Swati, Gustavsson, Tobias, Sorensen, P. H., Meyer, T., Propper, D., Shamash, J., Theander, Thor Grundtvig, Aicher, A., Daugaard, M., Heeschen, C. & Salanti, Ali, 2018, In: Nature Communications. 9, 1, 13 p., 3279.Research output: Contribution to journal › Journal article › Research › peer-review
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The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains
Dahlbäck, M., Jørgensen, L. M., Nielsen, Morten Agertoug, Clausen, T. M., Ditlev, S. B., Resende, M., Pinto, V. V., Arnot, D. E., Theander, Thor Grundtvig & Salanti, Ali, 2011, In: The Journal of Biological Chemistry. 286, 18, p. 15908-17 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of adjuvants on the immune response induced by a DBL4e-ID4 VAR2CSA based Plasmodium falciparum vaccine against placental malaria
Pinto, V. V., Salanti, Ali, Joergensen, L. M., Dahlbäck, M., Resende, M., Ditlev, S. B., Agger, E. M., Arnot, D. E., Theander, Thor Grundtvig & Nielsen, Morten Agertoug, 2012, In: Vaccine. 30, 3, p. 572-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The immunogenicity of capsid-like particle vaccines in combination with different adjuvants using different routes of administration
Janitzek, C. M., Carlsen, P. H. R., Thrane, Susan, Khanna, V. M., Jakob, V., Barnier-Quer, C., Collin, N., Theander, Thor Grundtvig, Salanti, Ali, Nielsen, Morten Agertoug & Sander, Adam F. , 2021, In: Vaccines. 9, 2, 131.Research output: Contribution to journal › Journal article › Research › peer-review
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Two-component nanoparticle vaccine displaying glycosylated spike S1 domain induces neutralizing antibody response against SARS-CoV-2 variants
van Oosten, L., Altenburg, J. J., Fougeroux, C., Geertsema, C., van den End, F., Evers, W. A. C., Westphal, A. H., Lindhoud, S., van den Berg, W., Swarts, D. C., Deurhof, L., Suhrbier, A., Le, T. T., Torres Morales, S., Myeni, S. K., Kikkert, M., Sander, A. F., de Jongh, W. A., Dagil, R., Nielsen, M. A. & 9 others, , 26 Oct 2021, In: mBio. 12, 5, e0181321.Research output: Contribution to journal › Journal article › Research › peer-review
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Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers
Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Sørensen, Andreas Holst Holmegaard, Jørgensen, T., Clemmensen, S., Soroka, V., Thrane, Susan, Theander, Thor Grundtvig, Nielsen, Morten Agertoug, Salanti, Ali, Bukh, Jens & Sander, Adam F. , 2022, In: npj Vaccines. 7, 148.Research output: Contribution to journal › Journal article › Research › peer-review
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Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA
Ditlev, S. B., Florea, R., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Magez, S., Boeuf, P. & Salanti, Ali, 21 Jan 2014, In: PLOS ONE. 9, 1, p. e84981Research output: Contribution to journal › Journal article › Research › peer-review
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VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes
Magistrado, P., Salanti, Ali, Tuikue Ndam, N. G., Mwakalinga, S. B., Resende, M., Dahlbäck, M., Hviid, Lars, Lusingu, J., Theander, Thor Grundtvig & Nielsen, Morten Agertoug, 2008, In: Journal of Infectious Diseases.Research output: Contribution to journal › Journal article › Research › peer-review
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Virus-like particle display of HER2 induces potent anti-cancer responses
Palladini, A., Thrane, Susan, Janitzek, C. M., Pihl, J., Clemmensen, S. B., de Jongh, W. A., Clausen, Thomas Mandel, Nicoletti, G., Landuzzi, L., Penichet, M. L., Balboni, T., Ianzano, M. L., Giusti, V., Theander, Thor Grundtvig, Nielsen, Morten Agertoug, Salanti, Ali, Lollini, P., Nanni, P. & Sander, Adam F. , 2018, In: OncoImmunology. 7, 3, 12 p., e1408749.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 3145601
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Bacterial superglue enables easy development of efficient virus-like particle based vaccines
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Placental sequestration of Plasmodium falciparum malaria parasites is mediated by the interaction between VAR2CSA and chondroitin sulfate A on syndecan-1
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Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria
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