Unchanged acetylation of isoniazid by alcohol intake
Research output: Contribution to journal › Journal article › Research › peer-review
SETTING: In 10 healthy subjects, the influence of acute alcohol intake on the pharmacokinetics of isoniazid (INH) was studied. OBJECTIVE: To test the hypothesis that alcohol increases the conversion of INH by acetylation into its metabolite acetylisoniazid. DESIGN: In a crossover design, an oral dose of 300 mg INH was administered on 2 separate days, 14 days apart, with or without alcohol to a serum alcohol of about 21 mmol/l (1 g/l) maintained for 12 h. RESULTS: Neither the metabolism of INH nor that of acetylisoniazid was changed by acute alcohol intake. CONCLUSION: Acute alcohol intake has no impact on the conversion of INH to its metabolite acetylisoniazid, which is catalysed by the enzyme N-acetyltranferase. Accordingly, a metabolic effect of acute alcohol intake on INH metabolism probably contributes little to the therapeutic failure of anti-tuberculosis treatment among alcoholics.
Original language | English |
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Journal | International Journal of Tuberculosis and Lung Disease |
Volume | 8 |
Issue number | 11 |
Pages (from-to) | 1373-6 |
Number of pages | 3 |
ISSN | 1027-3719 |
Publication status | Published - 2004 |
ID: 17656907