Trends in chloroquine resistance marker, Pfcrt-K76T mutation ten years after chloroquine withdrawal in Tanzania
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Trends in chloroquine resistance marker, Pfcrt-K76T mutation ten years after chloroquine withdrawal in Tanzania. / Mohammed, Asia; Ndaro, Arnold; Kalinga, Akili; Manjurano, Alphaxard; Mosha, Jackline F; Mosha, Dominick F; van Zwetselaar, Marco; Koenderink, Jan B; Mosha, Frank W; Alifrangis, Michael; Reyburn, Hugh; Roper, Cally; Kavishe, Reginald A.
In: Malaria Journal, Vol. 12, No. 1, 14.11.2013, p. 415.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Trends in chloroquine resistance marker, Pfcrt-K76T mutation ten years after chloroquine withdrawal in Tanzania
AU - Mohammed, Asia
AU - Ndaro, Arnold
AU - Kalinga, Akili
AU - Manjurano, Alphaxard
AU - Mosha, Jackline F
AU - Mosha, Dominick F
AU - van Zwetselaar, Marco
AU - Koenderink, Jan B
AU - Mosha, Frank W
AU - Alifrangis, Michael
AU - Reyburn, Hugh
AU - Roper, Cally
AU - Kavishe, Reginald A
PY - 2013/11/14
Y1 - 2013/11/14
N2 - Plasmodium falciparum resistance to anti-malarial drugs remains a major obstacle to the control of malaria. In 2001 Tanzania replaced chloroquine (CQ) with sulphadoxine-pyrimethamine (SP) as first-line drug, which in turn was replaced by artemisinin combination therapy in 2006. SP has however, continued to be used in intermittent preventive treatment of malaria in pregnancy (IPTp) despite reports of high levels of resistance to SP due to the lack of alternatives to SP for IPTp. Recent reports have indicated recovery of CQ-susceptibility in Malawi, Kenya, Mozambique, and Tanzania based on the prevalence of wild types at codon 76 of the Pfcrt gene in indigenous P. falciparum populations. The current prevalence of this Pfcrt-76 CQ resistance marker from six regions of Tanzania mainland is hereby reported.
AB - Plasmodium falciparum resistance to anti-malarial drugs remains a major obstacle to the control of malaria. In 2001 Tanzania replaced chloroquine (CQ) with sulphadoxine-pyrimethamine (SP) as first-line drug, which in turn was replaced by artemisinin combination therapy in 2006. SP has however, continued to be used in intermittent preventive treatment of malaria in pregnancy (IPTp) despite reports of high levels of resistance to SP due to the lack of alternatives to SP for IPTp. Recent reports have indicated recovery of CQ-susceptibility in Malawi, Kenya, Mozambique, and Tanzania based on the prevalence of wild types at codon 76 of the Pfcrt gene in indigenous P. falciparum populations. The current prevalence of this Pfcrt-76 CQ resistance marker from six regions of Tanzania mainland is hereby reported.
U2 - 10.1186/1475-2875-12-415
DO - 10.1186/1475-2875-12-415
M3 - Journal article
C2 - 24225406
VL - 12
SP - 415
JO - Malaria Journal
JF - Malaria Journal
SN - 1475-2875
IS - 1
ER -
ID: 80636422