The relation between T-cell expression of LFA-1 and immunological memory

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The relation between T-cell expression of LFA-1 and immunological memory. / Hviid, L; Odum, N; Theander, T G.

In: Immunology, Vol. 78, No. 2, 1993, p. 237-43.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hviid, L, Odum, N & Theander, TG 1993, 'The relation between T-cell expression of LFA-1 and immunological memory', Immunology, vol. 78, no. 2, pp. 237-43.

APA

Hviid, L., Odum, N., & Theander, T. G. (1993). The relation between T-cell expression of LFA-1 and immunological memory. Immunology, 78(2), 237-43.

Vancouver

Hviid L, Odum N, Theander TG. The relation between T-cell expression of LFA-1 and immunological memory. Immunology. 1993;78(2):237-43.

Author

Hviid, L ; Odum, N ; Theander, T G. / The relation between T-cell expression of LFA-1 and immunological memory. In: Immunology. 1993 ; Vol. 78, No. 2. pp. 237-43.

Bibtex

@article{b82cfbc0a07011dd86a6000ea68e967b,
title = "The relation between T-cell expression of LFA-1 and immunological memory",
abstract = "Antibodies against isotypes of the leucocyte common antigen (LCA, CD45) can be used to identify largely reciprocal subsets of human peripheral T cells, characterized by differential ability to respond to recall antigen in vitro. The transition from naive, unprimed T cells to memory cells capable of responding to recall stimulating has been associated with a switch in surface expression of CD45 from the CD45RA isotype to CD45RO. It has been proposed that this transition is accompanied by the coordinated up-regulation of a number of cell-surface molecules involved in cellular adhesion and/or activation, including the leucocyte function-associated antigens (LFA). In the present study we have examined the expression of LFA-1 on subsets of human peripheral T cells, and related it to the expression of markers of cellular activation and CD45 isotypes, and thus to immunological memory. Our results suggest that the intensity of LFA-1 expression on the surface membrane of human peripheral T cells is not tightly associated with maturation status as judged by LCA isotype expression, but rather reflects the degree of cellular activation. This conclusion is supported by data of T-cell function in vitro, showing similar antigen- and mitogen-induced proliferative responses in T-cell subsets characterized by low as well as high surface expression of LFA-1.",
author = "L Hviid and N Odum and Theander, {T G}",
note = "Keywords: Adult; Antigens, CD; Antigens, CD11; Antigens, CD45; Cell Adhesion Molecules; Cells, Cultured; Humans; Immunologic Memory; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Receptors, Interleukin-2; T-Lymphocyte Subsets; T-Lymphocytes",
year = "1993",
language = "English",
volume = "78",
pages = "237--43",
journal = "Immunology",
issn = "0019-2805",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - The relation between T-cell expression of LFA-1 and immunological memory

AU - Hviid, L

AU - Odum, N

AU - Theander, T G

N1 - Keywords: Adult; Antigens, CD; Antigens, CD11; Antigens, CD45; Cell Adhesion Molecules; Cells, Cultured; Humans; Immunologic Memory; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Receptors, Interleukin-2; T-Lymphocyte Subsets; T-Lymphocytes

PY - 1993

Y1 - 1993

N2 - Antibodies against isotypes of the leucocyte common antigen (LCA, CD45) can be used to identify largely reciprocal subsets of human peripheral T cells, characterized by differential ability to respond to recall antigen in vitro. The transition from naive, unprimed T cells to memory cells capable of responding to recall stimulating has been associated with a switch in surface expression of CD45 from the CD45RA isotype to CD45RO. It has been proposed that this transition is accompanied by the coordinated up-regulation of a number of cell-surface molecules involved in cellular adhesion and/or activation, including the leucocyte function-associated antigens (LFA). In the present study we have examined the expression of LFA-1 on subsets of human peripheral T cells, and related it to the expression of markers of cellular activation and CD45 isotypes, and thus to immunological memory. Our results suggest that the intensity of LFA-1 expression on the surface membrane of human peripheral T cells is not tightly associated with maturation status as judged by LCA isotype expression, but rather reflects the degree of cellular activation. This conclusion is supported by data of T-cell function in vitro, showing similar antigen- and mitogen-induced proliferative responses in T-cell subsets characterized by low as well as high surface expression of LFA-1.

AB - Antibodies against isotypes of the leucocyte common antigen (LCA, CD45) can be used to identify largely reciprocal subsets of human peripheral T cells, characterized by differential ability to respond to recall antigen in vitro. The transition from naive, unprimed T cells to memory cells capable of responding to recall stimulating has been associated with a switch in surface expression of CD45 from the CD45RA isotype to CD45RO. It has been proposed that this transition is accompanied by the coordinated up-regulation of a number of cell-surface molecules involved in cellular adhesion and/or activation, including the leucocyte function-associated antigens (LFA). In the present study we have examined the expression of LFA-1 on subsets of human peripheral T cells, and related it to the expression of markers of cellular activation and CD45 isotypes, and thus to immunological memory. Our results suggest that the intensity of LFA-1 expression on the surface membrane of human peripheral T cells is not tightly associated with maturation status as judged by LCA isotype expression, but rather reflects the degree of cellular activation. This conclusion is supported by data of T-cell function in vitro, showing similar antigen- and mitogen-induced proliferative responses in T-cell subsets characterized by low as well as high surface expression of LFA-1.

M3 - Journal article

C2 - 8097182

VL - 78

SP - 237

EP - 243

JO - Immunology

JF - Immunology

SN - 0019-2805

IS - 2

ER -

ID: 6748392