The rapid and spontaneous postpartum clearance of Plasmodium falciparum is related to expulsion of the placenta
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The rapid and spontaneous postpartum clearance of Plasmodium falciparum is related to expulsion of the placenta. / Anabire, Nsoh G; Quintana, Maria Del Pilar; Ofori, Michael F; Hviid, Lars.
In: The Journal of Infectious Diseases, Vol. 228, No. 2, 2023, p. 196-201.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The rapid and spontaneous postpartum clearance of Plasmodium falciparum is related to expulsion of the placenta
AU - Anabire, Nsoh G
AU - Quintana, Maria Del Pilar
AU - Ofori, Michael F
AU - Hviid, Lars
N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2023
Y1 - 2023
N2 - Parasitemia among pregnant women with protective immunity to Plasmodium falciparum malaria is often dominated by VAR2CSA-positive infected erythrocytes (IEs). VAR2CSA mediates sequestration of IEs in the placenta. We hypothesized that the previously observed spontaneous postpartum clearance of parasitemia in such women is related to the expulsion of the placenta, which removes the sequestration focus of VAR2CSA-positive IEs. We assessed parasitemias and gene transcription before and shortly after delivery in 17 Ghanaian women. The precipitous decline in parasitemia postpartum was accompanied by selective reduction in transcription of the gene encoding VAR2CSA. Our findings provide a mechanistic explanation for the earlier observation.
AB - Parasitemia among pregnant women with protective immunity to Plasmodium falciparum malaria is often dominated by VAR2CSA-positive infected erythrocytes (IEs). VAR2CSA mediates sequestration of IEs in the placenta. We hypothesized that the previously observed spontaneous postpartum clearance of parasitemia in such women is related to the expulsion of the placenta, which removes the sequestration focus of VAR2CSA-positive IEs. We assessed parasitemias and gene transcription before and shortly after delivery in 17 Ghanaian women. The precipitous decline in parasitemia postpartum was accompanied by selective reduction in transcription of the gene encoding VAR2CSA. Our findings provide a mechanistic explanation for the earlier observation.
KW - Female
KW - Pregnancy
KW - Humans
KW - Plasmodium falciparum/genetics
KW - Parasitemia
KW - Ghana
KW - Antigens, Protozoan
KW - Protozoan Proteins
KW - Placenta
KW - Malaria, Falciparum
KW - Erythrocytes
KW - Pregnancy Complications, Parasitic
KW - Postpartum Period
KW - Antibodies, Protozoan
U2 - 10.1093/infdis/jiad031
DO - 10.1093/infdis/jiad031
M3 - Journal article
C2 - 36740589
VL - 228
SP - 196
EP - 201
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 2
ER -
ID: 359603324