The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer. / Wang, Christian W; Hermsen, Cornelus C; Sauerwein, Robert W; Arnot, David E; Theander, Thor G; Lavstsen, Thomas.

In: Parasitology International, Vol. 58, No. 4, 2009, p. 478-80.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wang, CW, Hermsen, CC, Sauerwein, RW, Arnot, DE, Theander, TG & Lavstsen, T 2009, 'The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer', Parasitology International, vol. 58, no. 4, pp. 478-80. https://doi.org/10.1016/j.parint.2009.07.004

APA

Wang, C. W., Hermsen, C. C., Sauerwein, R. W., Arnot, D. E., Theander, T. G., & Lavstsen, T. (2009). The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer. Parasitology International, 58(4), 478-80. https://doi.org/10.1016/j.parint.2009.07.004

Vancouver

Wang CW, Hermsen CC, Sauerwein RW, Arnot DE, Theander TG, Lavstsen T. The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer. Parasitology International. 2009;58(4):478-80. https://doi.org/10.1016/j.parint.2009.07.004

Author

Wang, Christian W ; Hermsen, Cornelus C ; Sauerwein, Robert W ; Arnot, David E ; Theander, Thor G ; Lavstsen, Thomas. / The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer. In: Parasitology International. 2009 ; Vol. 58, No. 4. pp. 478-80.

Bibtex

@article{aaa227b0038d11df825d000ea68e967b,
title = "The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer",
abstract = "The var genes encode a family of adhesion receptor proteins, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which profoundly influence malaria pathogenesis. Only a single var gene is transcribed and one PfEMP1 expressed per P.falciparum parasite. Here we present the in vivo transcript distribution of var genes in a P. falciparum-infected non-immune individual and show that the initial expression of PfEMP1 is based on a strategy that allows all or most variants of PfEMP1s to be expressed by the parasite population at the onset of the blood stage infection.",
author = "Wang, {Christian W} and Hermsen, {Cornelus C} and Sauerwein, {Robert W} and Arnot, {David E} and Theander, {Thor G} and Thomas Lavstsen",
year = "2009",
doi = "10.1016/j.parint.2009.07.004",
language = "English",
volume = "58",
pages = "478--80",
journal = "Parasitology International",
issn = "1383-5769",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer

AU - Wang, Christian W

AU - Hermsen, Cornelus C

AU - Sauerwein, Robert W

AU - Arnot, David E

AU - Theander, Thor G

AU - Lavstsen, Thomas

PY - 2009

Y1 - 2009

N2 - The var genes encode a family of adhesion receptor proteins, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which profoundly influence malaria pathogenesis. Only a single var gene is transcribed and one PfEMP1 expressed per P.falciparum parasite. Here we present the in vivo transcript distribution of var genes in a P. falciparum-infected non-immune individual and show that the initial expression of PfEMP1 is based on a strategy that allows all or most variants of PfEMP1s to be expressed by the parasite population at the onset of the blood stage infection.

AB - The var genes encode a family of adhesion receptor proteins, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which profoundly influence malaria pathogenesis. Only a single var gene is transcribed and one PfEMP1 expressed per P.falciparum parasite. Here we present the in vivo transcript distribution of var genes in a P. falciparum-infected non-immune individual and show that the initial expression of PfEMP1 is based on a strategy that allows all or most variants of PfEMP1s to be expressed by the parasite population at the onset of the blood stage infection.

U2 - 10.1016/j.parint.2009.07.004

DO - 10.1016/j.parint.2009.07.004

M3 - Journal article

C2 - 19616120

VL - 58

SP - 478

EP - 480

JO - Parasitology International

JF - Parasitology International

SN - 1383-5769

IS - 4

ER -

ID: 17055131