Tetranectin: a novel secretory protein from human monocytes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Tetranectin: a novel secretory protein from human monocytes. / Nielsen, H; Clemmensen, I; Kharazmi, A.

In: Scandinavian Journal of Immunology, Vol. 37, No. 1, 1993, p. 39-42.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, H, Clemmensen, I & Kharazmi, A 1993, 'Tetranectin: a novel secretory protein from human monocytes', Scandinavian Journal of Immunology, vol. 37, no. 1, pp. 39-42.

APA

Nielsen, H., Clemmensen, I., & Kharazmi, A. (1993). Tetranectin: a novel secretory protein from human monocytes. Scandinavian Journal of Immunology, 37(1), 39-42.

Vancouver

Nielsen H, Clemmensen I, Kharazmi A. Tetranectin: a novel secretory protein from human monocytes. Scandinavian Journal of Immunology. 1993;37(1):39-42.

Author

Nielsen, H ; Clemmensen, I ; Kharazmi, A. / Tetranectin: a novel secretory protein from human monocytes. In: Scandinavian Journal of Immunology. 1993 ; Vol. 37, No. 1. pp. 39-42.

Bibtex

@article{806a0b301fb111df8ed1000ea68e967b,
title = "Tetranectin: a novel secretory protein from human monocytes",
abstract = "Tetranectin is a recently described human plasma protein, which is found in most secretory cells throughout the body, including neutrophils. We present evidence for the presence of tetranectin in human monocytes and macrophages as well, and that these cells upon adherence or weak stimulation release a 20 kDa protein identified as tetranectin by immunoblotting. The amount of tetranectin released is 3-18 ng/h/10(6) monocytes. The possible influence of tetranectin on cellular functions was tested in migration and oxidative metabolism assays. Monocyte spontaneous migration was significantly stimulated by preincubation with purified tetranectin, whereas chemotactic and chemiluminescence responses to fMLP and C5a were unchanged. Neutrophil functions were not affected. It is concluded that tetranectin is secreted from human mononuclear phagocytes upon weak stimulation, and that the secreted tetranectin facilities spontaneous migration of these cells.",
author = "H Nielsen and I Clemmensen and A Kharazmi",
note = "Keywords: Blood Proteins; Cells, Cultured; Chemotaxis; Humans; Lectins, C-Type; Monocytes; Neutrophils",
year = "1993",
language = "English",
volume = "37",
pages = "39--42",
journal = "Scandinavian Journal of Immunology, Supplement",
issn = "0301-6323",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Tetranectin: a novel secretory protein from human monocytes

AU - Nielsen, H

AU - Clemmensen, I

AU - Kharazmi, A

N1 - Keywords: Blood Proteins; Cells, Cultured; Chemotaxis; Humans; Lectins, C-Type; Monocytes; Neutrophils

PY - 1993

Y1 - 1993

N2 - Tetranectin is a recently described human plasma protein, which is found in most secretory cells throughout the body, including neutrophils. We present evidence for the presence of tetranectin in human monocytes and macrophages as well, and that these cells upon adherence or weak stimulation release a 20 kDa protein identified as tetranectin by immunoblotting. The amount of tetranectin released is 3-18 ng/h/10(6) monocytes. The possible influence of tetranectin on cellular functions was tested in migration and oxidative metabolism assays. Monocyte spontaneous migration was significantly stimulated by preincubation with purified tetranectin, whereas chemotactic and chemiluminescence responses to fMLP and C5a were unchanged. Neutrophil functions were not affected. It is concluded that tetranectin is secreted from human mononuclear phagocytes upon weak stimulation, and that the secreted tetranectin facilities spontaneous migration of these cells.

AB - Tetranectin is a recently described human plasma protein, which is found in most secretory cells throughout the body, including neutrophils. We present evidence for the presence of tetranectin in human monocytes and macrophages as well, and that these cells upon adherence or weak stimulation release a 20 kDa protein identified as tetranectin by immunoblotting. The amount of tetranectin released is 3-18 ng/h/10(6) monocytes. The possible influence of tetranectin on cellular functions was tested in migration and oxidative metabolism assays. Monocyte spontaneous migration was significantly stimulated by preincubation with purified tetranectin, whereas chemotactic and chemiluminescence responses to fMLP and C5a were unchanged. Neutrophil functions were not affected. It is concluded that tetranectin is secreted from human mononuclear phagocytes upon weak stimulation, and that the secreted tetranectin facilities spontaneous migration of these cells.

M3 - Journal article

C2 - 8418471

VL - 37

SP - 39

EP - 42

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

SN - 0301-6323

IS - 1

ER -

ID: 18153143