Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin: Role of opsonizing antibodies to Plasmodium falciparum merozoites

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Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin : Role of opsonizing antibodies to Plasmodium falciparum merozoites. / Fall, Abdou Khadre Dit Jadir; Kana, Ikhlaq Hussain; Garcia-Senosiain, Asier; Henry, Benoît; Dechavanne, Célia; Garcia, André; Buffet, Pierre; Sabbagh, Audrey; Migot-Nabias, Florence; Theisen, Michael; Courtin, David.

In: Heliyon, Vol. 9, No. 1, e13092, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fall, AKDJ, Kana, IH, Garcia-Senosiain, A, Henry, B, Dechavanne, C, Garcia, A, Buffet, P, Sabbagh, A, Migot-Nabias, F, Theisen, M & Courtin, D 2023, 'Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin: Role of opsonizing antibodies to Plasmodium falciparum merozoites', Heliyon, vol. 9, no. 1, e13092. https://doi.org/10.1016/j.heliyon.2023.e13092

APA

Fall, A. K. D. J., Kana, I. H., Garcia-Senosiain, A., Henry, B., Dechavanne, C., Garcia, A., Buffet, P., Sabbagh, A., Migot-Nabias, F., Theisen, M., & Courtin, D. (2023). Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin: Role of opsonizing antibodies to Plasmodium falciparum merozoites. Heliyon, 9(1), [e13092]. https://doi.org/10.1016/j.heliyon.2023.e13092

Vancouver

Fall AKDJ, Kana IH, Garcia-Senosiain A, Henry B, Dechavanne C, Garcia A et al. Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin: Role of opsonizing antibodies to Plasmodium falciparum merozoites. Heliyon. 2023;9(1). e13092. https://doi.org/10.1016/j.heliyon.2023.e13092

Author

Fall, Abdou Khadre Dit Jadir ; Kana, Ikhlaq Hussain ; Garcia-Senosiain, Asier ; Henry, Benoît ; Dechavanne, Célia ; Garcia, André ; Buffet, Pierre ; Sabbagh, Audrey ; Migot-Nabias, Florence ; Theisen, Michael ; Courtin, David. / Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin : Role of opsonizing antibodies to Plasmodium falciparum merozoites. In: Heliyon. 2023 ; Vol. 9, No. 1.

Bibtex

@article{35dce7c80f254a94840884ac1f7ee6cc,
title = "Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin: Role of opsonizing antibodies to Plasmodium falciparum merozoites",
abstract = "OBJECTIVES: Fulani in Africa are known to be less susceptible to Plasmodium falciparum (Pf) malaria. This study explored a potential involvement of antibody-mediated merozoite phagocytosis mechanism in this natural protection against malaria.METHODS: Before the start of the malaria transmission season (MTS) in Benin, the functionality of antibodies against Pf merozoites was determined by the opsonic phagocytosis (OP) assay in plasma samples from Fulani, Bariba, Otamari and Gando groups. These individuals were actively followed-up for malaria detection from the beginning to the end of MTS. Anti-GLURP Immunoglobulin G antibody quantification, malaria Rapid Diagnostic Test (RDT) and spleen palpation were performed before and after MTS.RESULTS: In Bariba, Otamari and Gando, but not in Fulani, plasma from adults promoted higher levels of OP than the children (P = 0.003; P = 0.012; P = 0.031 and P = 0.122). A high proportion of Fulani children had higher OP and anti-GLURP (P < 0.0001) antibody levels as compared to non-Fulani children; whereas this was not observed for Fulani adults (P = 0.223). High OP levels before MTS were significantly related to negative RDT after MTS (P = 0.011).CONCLUSION: Our results highlight the ability of opsonizing antibodies to potentially enhance natural protection of young Fulani individuals against Pf malaria in Benin.",
author = "Fall, {Abdou Khadre Dit Jadir} and Kana, {Ikhlaq Hussain} and Asier Garcia-Senosiain and Beno{\^i}t Henry and C{\'e}lia Dechavanne and Andr{\'e} Garcia and Pierre Buffet and Audrey Sabbagh and Florence Migot-Nabias and Michael Theisen and David Courtin",
note = "{\textcopyright} 2023 The Authors.",
year = "2023",
doi = "10.1016/j.heliyon.2023.e13092",
language = "English",
volume = "9",
journal = "Heliyon",
issn = "2405-8440",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin

T2 - Role of opsonizing antibodies to Plasmodium falciparum merozoites

AU - Fall, Abdou Khadre Dit Jadir

AU - Kana, Ikhlaq Hussain

AU - Garcia-Senosiain, Asier

AU - Henry, Benoît

AU - Dechavanne, Célia

AU - Garcia, André

AU - Buffet, Pierre

AU - Sabbagh, Audrey

AU - Migot-Nabias, Florence

AU - Theisen, Michael

AU - Courtin, David

N1 - © 2023 The Authors.

PY - 2023

Y1 - 2023

N2 - OBJECTIVES: Fulani in Africa are known to be less susceptible to Plasmodium falciparum (Pf) malaria. This study explored a potential involvement of antibody-mediated merozoite phagocytosis mechanism in this natural protection against malaria.METHODS: Before the start of the malaria transmission season (MTS) in Benin, the functionality of antibodies against Pf merozoites was determined by the opsonic phagocytosis (OP) assay in plasma samples from Fulani, Bariba, Otamari and Gando groups. These individuals were actively followed-up for malaria detection from the beginning to the end of MTS. Anti-GLURP Immunoglobulin G antibody quantification, malaria Rapid Diagnostic Test (RDT) and spleen palpation were performed before and after MTS.RESULTS: In Bariba, Otamari and Gando, but not in Fulani, plasma from adults promoted higher levels of OP than the children (P = 0.003; P = 0.012; P = 0.031 and P = 0.122). A high proportion of Fulani children had higher OP and anti-GLURP (P < 0.0001) antibody levels as compared to non-Fulani children; whereas this was not observed for Fulani adults (P = 0.223). High OP levels before MTS were significantly related to negative RDT after MTS (P = 0.011).CONCLUSION: Our results highlight the ability of opsonizing antibodies to potentially enhance natural protection of young Fulani individuals against Pf malaria in Benin.

AB - OBJECTIVES: Fulani in Africa are known to be less susceptible to Plasmodium falciparum (Pf) malaria. This study explored a potential involvement of antibody-mediated merozoite phagocytosis mechanism in this natural protection against malaria.METHODS: Before the start of the malaria transmission season (MTS) in Benin, the functionality of antibodies against Pf merozoites was determined by the opsonic phagocytosis (OP) assay in plasma samples from Fulani, Bariba, Otamari and Gando groups. These individuals were actively followed-up for malaria detection from the beginning to the end of MTS. Anti-GLURP Immunoglobulin G antibody quantification, malaria Rapid Diagnostic Test (RDT) and spleen palpation were performed before and after MTS.RESULTS: In Bariba, Otamari and Gando, but not in Fulani, plasma from adults promoted higher levels of OP than the children (P = 0.003; P = 0.012; P = 0.031 and P = 0.122). A high proportion of Fulani children had higher OP and anti-GLURP (P < 0.0001) antibody levels as compared to non-Fulani children; whereas this was not observed for Fulani adults (P = 0.223). High OP levels before MTS were significantly related to negative RDT after MTS (P = 0.011).CONCLUSION: Our results highlight the ability of opsonizing antibodies to potentially enhance natural protection of young Fulani individuals against Pf malaria in Benin.

U2 - 10.1016/j.heliyon.2023.e13092

DO - 10.1016/j.heliyon.2023.e13092

M3 - Journal article

C2 - 36711279

VL - 9

JO - Heliyon

JF - Heliyon

SN - 2405-8440

IS - 1

M1 - e13092

ER -

ID: 336881986