Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum

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Standard

Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum. / Jakobsen, P H; Hviid, L; Theander, T G; Afare, E A; Ridley, R G; Heegaard, P M; Stuber, D; Dalsgaard, K; Nkrumah, F K.

In: Infection and Immunity, Vol. 61, No. 1, 1993, p. 268-73.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jakobsen, PH, Hviid, L, Theander, TG, Afare, EA, Ridley, RG, Heegaard, PM, Stuber, D, Dalsgaard, K & Nkrumah, FK 1993, 'Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum', Infection and Immunity, vol. 61, no. 1, pp. 268-73.

APA

Jakobsen, P. H., Hviid, L., Theander, T. G., Afare, E. A., Ridley, R. G., Heegaard, P. M., Stuber, D., Dalsgaard, K., & Nkrumah, F. K. (1993). Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum. Infection and Immunity, 61(1), 268-73.

Vancouver

Jakobsen PH, Hviid L, Theander TG, Afare EA, Ridley RG, Heegaard PM et al. Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum. Infection and Immunity. 1993;61(1):268-73.

Author

Jakobsen, P H ; Hviid, L ; Theander, T G ; Afare, E A ; Ridley, R G ; Heegaard, P M ; Stuber, D ; Dalsgaard, K ; Nkrumah, F K. / Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum. In: Infection and Immunity. 1993 ; Vol. 61, No. 1. pp. 268-73.

Bibtex

@article{999d3bb0a07111dd86a6000ea68e967b,
title = "Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum",
abstract = "The merozoite proteins merozoite surface protein 1 (MSP-1) and rhoptry-associated protein 1 (RAP-1) and synthetic peptides containing sequences of MSP-1, RAP-1, and erythrocyte-binding antigen 1, induced in vitro proliferative responses of lymphocytes collected from Ghanaian blood donors living in an area with a high rate of transmission of malaria. Lymphocytes from a large proportion of the Ghanaian blood donors proliferated in response to the RAP-1 peptide, unlike those of Danish control blood donors, indicating that this sequence contains a malaria-specific T-cell epitope broadly recognized by individuals living in an area with a high transmission rate of malaria. Most of the donor plasma samples tested contained immunoglobulin G (IgG) and IgM antibodies recognizing the merozoite proteins, while only a minority showed high IgG reactivity to the synthetic peptides.",
author = "Jakobsen, {P H} and L Hviid and Theander, {T G} and Afare, {E A} and Ridley, {R G} and Heegaard, {P M} and D Stuber and K Dalsgaard and Nkrumah, {F K}",
note = "Keywords: Adolescent; Adult; Amino Acid Sequence; Antigens, Protozoan; Antigens, Surface; Carrier Proteins; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Humans; Immunity, Cellular; Immunoglobulin G; Immunoglobulin M; Lymphocyte Activation; Malaria, Falciparum; Merozoite Surface Protein 1; Middle Aged; Molecular Sequence Data; Protein Precursors; Protozoan Proteins; Receptors, Cell Surface; T-Lymphocytes",
year = "1993",
language = "English",
volume = "61",
pages = "268--73",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "1",

}

RIS

TY - JOUR

T1 - Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum

AU - Jakobsen, P H

AU - Hviid, L

AU - Theander, T G

AU - Afare, E A

AU - Ridley, R G

AU - Heegaard, P M

AU - Stuber, D

AU - Dalsgaard, K

AU - Nkrumah, F K

N1 - Keywords: Adolescent; Adult; Amino Acid Sequence; Antigens, Protozoan; Antigens, Surface; Carrier Proteins; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Humans; Immunity, Cellular; Immunoglobulin G; Immunoglobulin M; Lymphocyte Activation; Malaria, Falciparum; Merozoite Surface Protein 1; Middle Aged; Molecular Sequence Data; Protein Precursors; Protozoan Proteins; Receptors, Cell Surface; T-Lymphocytes

PY - 1993

Y1 - 1993

N2 - The merozoite proteins merozoite surface protein 1 (MSP-1) and rhoptry-associated protein 1 (RAP-1) and synthetic peptides containing sequences of MSP-1, RAP-1, and erythrocyte-binding antigen 1, induced in vitro proliferative responses of lymphocytes collected from Ghanaian blood donors living in an area with a high rate of transmission of malaria. Lymphocytes from a large proportion of the Ghanaian blood donors proliferated in response to the RAP-1 peptide, unlike those of Danish control blood donors, indicating that this sequence contains a malaria-specific T-cell epitope broadly recognized by individuals living in an area with a high transmission rate of malaria. Most of the donor plasma samples tested contained immunoglobulin G (IgG) and IgM antibodies recognizing the merozoite proteins, while only a minority showed high IgG reactivity to the synthetic peptides.

AB - The merozoite proteins merozoite surface protein 1 (MSP-1) and rhoptry-associated protein 1 (RAP-1) and synthetic peptides containing sequences of MSP-1, RAP-1, and erythrocyte-binding antigen 1, induced in vitro proliferative responses of lymphocytes collected from Ghanaian blood donors living in an area with a high rate of transmission of malaria. Lymphocytes from a large proportion of the Ghanaian blood donors proliferated in response to the RAP-1 peptide, unlike those of Danish control blood donors, indicating that this sequence contains a malaria-specific T-cell epitope broadly recognized by individuals living in an area with a high transmission rate of malaria. Most of the donor plasma samples tested contained immunoglobulin G (IgG) and IgM antibodies recognizing the merozoite proteins, while only a minority showed high IgG reactivity to the synthetic peptides.

M3 - Journal article

C2 - 8418048

VL - 61

SP - 268

EP - 273

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 1

ER -

ID: 6748420