Serine-stretch protein (SERP) of Plasmodium falciparum corresponds to the exoantigen Ag2, a target of antibodies associated with protection against malaria
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A mixture of Plasmodium falciparum exoantigens inducing lymphocyte activation and cytokine production was shown to contain the malaria vaccine candidate, the serine-stretch protein. This protein was shown serologically to correspond to Ag2, an exoantigen recognized by antibodies linked with protection against malaria. The glycophorin-binding protein, the histidine-rich protein II, the S-antigen, the heat shock protein 70, the ring-infected erythrocyte surface antigen, and the apical membrane antigen-1 were also shown serologically to be present in the mixture of exoantigens.
Original language | English |
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Journal | Acta Pathologica Microbiologica et Immunologica Scandinavica |
Volume | 102 |
Issue number | 1 |
Pages (from-to) | 53-8 |
Number of pages | 5 |
ISSN | 0903-4641 |
Publication status | Published - 1994 |
Bibliographical note
Keywords: Amino Acid Sequence; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antigens, Surface; Electrophoresis, Polyacrylamide Gel; Heat-Shock Proteins; Humans; Immune Sera; Immunoblotting; Immunoelectrophoresis, Two-Dimensional; Malaria Vaccines; Malaria, Falciparum; Molecular Sequence Data; Proteins; Protozoan Proteins; Rabbits
ID: 18106947