Responding to the challenge of antimalarial drug resistance by routine monitoring to update national malaria treatment policies

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Standard

Responding to the challenge of antimalarial drug resistance by routine monitoring to update national malaria treatment policies. / Vestergaard, Lasse S; Ringwald, Pascal.

In: American Journal of Tropical Medicine and Hygiene, Vol. 77, No. 6 Suppl, 2007, p. 153-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vestergaard, LS & Ringwald, P 2007, 'Responding to the challenge of antimalarial drug resistance by routine monitoring to update national malaria treatment policies', American Journal of Tropical Medicine and Hygiene, vol. 77, no. 6 Suppl, pp. 153-9.

APA

Vestergaard, L. S., & Ringwald, P. (2007). Responding to the challenge of antimalarial drug resistance by routine monitoring to update national malaria treatment policies. American Journal of Tropical Medicine and Hygiene, 77(6 Suppl), 153-9.

Vancouver

Vestergaard LS, Ringwald P. Responding to the challenge of antimalarial drug resistance by routine monitoring to update national malaria treatment policies. American Journal of Tropical Medicine and Hygiene. 2007;77(6 Suppl):153-9.

Author

Vestergaard, Lasse S ; Ringwald, Pascal. / Responding to the challenge of antimalarial drug resistance by routine monitoring to update national malaria treatment policies. In: American Journal of Tropical Medicine and Hygiene. 2007 ; Vol. 77, No. 6 Suppl. pp. 153-9.

Bibtex

@article{822b7040b61b11ddae57000ea68e967b,
title = "Responding to the challenge of antimalarial drug resistance by routine monitoring to update national malaria treatment policies",
abstract = "Reduced sensitivity of Plasmodium falciparum to formerly recommended cheap and well-known antimalarial drugs places an increasing burden on malaria control programs and national health systems in endemic countries. The high costs of the new artemisinin-based combination treatments underline the use of rational and updated malaria treatment policies, but defining and updating such policies requires a sufficient volume of high-quality drug-resistance data collected at national and regional levels. Three main tools are used for drug resistance monitoring, including therapeutic efficacy tests, in vitro tests, and analyses of molecular markers. Data obtained with the therapeutic efficacy test conducted according to the standard protocol of the World Health Organization are most useful for updating national treatment policies, while the in vitro test and molecular markers can provide important additional information about changing patterns of resistance. However, some of the tests are technically demanding, and thus there is a need for more resources for training and capacity building in endemic countries to be able to adequately respond to the challenge of drug resistance.",
author = "Vestergaard, {Lasse S} and Pascal Ringwald",
note = "Keywords: Animals; Antimalarials; Drug Resistance, Multiple; Health Policy; Humans; Malaria, Falciparum; Plasmodium falciparum; Treatment Failure; World Health Organization",
year = "2007",
language = "English",
volume = "77",
pages = "153--9",
journal = "Journal. National Malaria Society",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "6 Suppl",

}

RIS

TY - JOUR

T1 - Responding to the challenge of antimalarial drug resistance by routine monitoring to update national malaria treatment policies

AU - Vestergaard, Lasse S

AU - Ringwald, Pascal

N1 - Keywords: Animals; Antimalarials; Drug Resistance, Multiple; Health Policy; Humans; Malaria, Falciparum; Plasmodium falciparum; Treatment Failure; World Health Organization

PY - 2007

Y1 - 2007

N2 - Reduced sensitivity of Plasmodium falciparum to formerly recommended cheap and well-known antimalarial drugs places an increasing burden on malaria control programs and national health systems in endemic countries. The high costs of the new artemisinin-based combination treatments underline the use of rational and updated malaria treatment policies, but defining and updating such policies requires a sufficient volume of high-quality drug-resistance data collected at national and regional levels. Three main tools are used for drug resistance monitoring, including therapeutic efficacy tests, in vitro tests, and analyses of molecular markers. Data obtained with the therapeutic efficacy test conducted according to the standard protocol of the World Health Organization are most useful for updating national treatment policies, while the in vitro test and molecular markers can provide important additional information about changing patterns of resistance. However, some of the tests are technically demanding, and thus there is a need for more resources for training and capacity building in endemic countries to be able to adequately respond to the challenge of drug resistance.

AB - Reduced sensitivity of Plasmodium falciparum to formerly recommended cheap and well-known antimalarial drugs places an increasing burden on malaria control programs and national health systems in endemic countries. The high costs of the new artemisinin-based combination treatments underline the use of rational and updated malaria treatment policies, but defining and updating such policies requires a sufficient volume of high-quality drug-resistance data collected at national and regional levels. Three main tools are used for drug resistance monitoring, including therapeutic efficacy tests, in vitro tests, and analyses of molecular markers. Data obtained with the therapeutic efficacy test conducted according to the standard protocol of the World Health Organization are most useful for updating national treatment policies, while the in vitro test and molecular markers can provide important additional information about changing patterns of resistance. However, some of the tests are technically demanding, and thus there is a need for more resources for training and capacity building in endemic countries to be able to adequately respond to the challenge of drug resistance.

M3 - Journal article

C2 - 18165488

VL - 77

SP - 153

EP - 159

JO - Journal. National Malaria Society

JF - Journal. National Malaria Society

SN - 0002-9637

IS - 6 Suppl

ER -

ID: 8692462