Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura

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Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura. / Esen, Meral; Mordmüller, Benjamin; de Salazar, Pablo Martinez; Adegnika, Ayola Akim; Agnandji, Selidji Todagbe; Schaumburg, Frieder; Hounkpatin, Aurore Bouyoukou; Brückner, Sina; Theisen, Michael; Bélard, Sabine; Ngoa, Ulysse Ateba; Issifou, Saadou; Yazdanbakhsh, Maria; Kremsner, Peter G.

In: Vaccine, Vol. 30, 2012, p. 7621-7624.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Esen, M, Mordmüller, B, de Salazar, PM, Adegnika, AA, Agnandji, ST, Schaumburg, F, Hounkpatin, AB, Brückner, S, Theisen, M, Bélard, S, Ngoa, UA, Issifou, S, Yazdanbakhsh, M & Kremsner, PG 2012, 'Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura', Vaccine, vol. 30, pp. 7621-7624. https://doi.org/10.1016/j.vaccine.2012.10.026

APA

Esen, M., Mordmüller, B., de Salazar, P. M., Adegnika, A. A., Agnandji, S. T., Schaumburg, F., Hounkpatin, A. B., Brückner, S., Theisen, M., Bélard, S., Ngoa, U. A., Issifou, S., Yazdanbakhsh, M., & Kremsner, P. G. (2012). Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura. Vaccine, 30, 7621-7624. https://doi.org/10.1016/j.vaccine.2012.10.026

Vancouver

Esen M, Mordmüller B, de Salazar PM, Adegnika AA, Agnandji ST, Schaumburg F et al. Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura. Vaccine. 2012;30:7621-7624. https://doi.org/10.1016/j.vaccine.2012.10.026

Author

Esen, Meral ; Mordmüller, Benjamin ; de Salazar, Pablo Martinez ; Adegnika, Ayola Akim ; Agnandji, Selidji Todagbe ; Schaumburg, Frieder ; Hounkpatin, Aurore Bouyoukou ; Brückner, Sina ; Theisen, Michael ; Bélard, Sabine ; Ngoa, Ulysse Ateba ; Issifou, Saadou ; Yazdanbakhsh, Maria ; Kremsner, Peter G. / Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura. In: Vaccine. 2012 ; Vol. 30. pp. 7621-7624.

Bibtex

@article{5883ddb6523a41a68b9c3853c1b150f7,
title = "Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura",
abstract = "BACKGROUND: Helminth infections are highly prevalent in the tropics and may have an effect on immune responses to vaccines due to their immunomodulatory effect. The prevalence of helminth infections in young children, the target group for malaria and most other vaccines, is high. Therefore we assessed the influence of helminth infection on vaccine-induced immune responses in a phase I clinical trial of the malaria vaccine candidate GMZ2. METHODS: Twenty Gabonese preschool-age children were vaccinated with GMZ2, a blood stage malaria vaccine candidate. Humoral immune response against the vaccine antigens and parasitological status were assessed. Vaccine-specific antibody concentrations and memory B-cell numbers were compared in worm infected and non-infected participants. RESULTS: Antibody response to GMZ2 was 3.4-fold (95% confidence interval: 1.6, 7.4) higher in Trichuris trichiura negative subjects compared to positive participants, whereas immunoglobulin subclass distribution was similar. Memory B-cell response was moderately increased in T. trichiura negative individuals, although the difference was not significant. CONCLUSIONS: Future malaria vaccine development programs need to account for worm-mediated hyporesponsiveness of immune reactions.",
author = "Meral Esen and Benjamin Mordm{\"u}ller and {de Salazar}, {Pablo Martinez} and Adegnika, {Ayola Akim} and Agnandji, {Selidji Todagbe} and Frieder Schaumburg and Hounkpatin, {Aurore Bouyoukou} and Sina Br{\"u}ckner and Michael Theisen and Sabine B{\'e}lard and Ngoa, {Ulysse Ateba} and Saadou Issifou and Maria Yazdanbakhsh and Kremsner, {Peter G}",
note = "Copyright {\textcopyright} 2012. Published by Elsevier Ltd.",
year = "2012",
doi = "10.1016/j.vaccine.2012.10.026",
language = "English",
volume = "30",
pages = "7621--7624",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura

AU - Esen, Meral

AU - Mordmüller, Benjamin

AU - de Salazar, Pablo Martinez

AU - Adegnika, Ayola Akim

AU - Agnandji, Selidji Todagbe

AU - Schaumburg, Frieder

AU - Hounkpatin, Aurore Bouyoukou

AU - Brückner, Sina

AU - Theisen, Michael

AU - Bélard, Sabine

AU - Ngoa, Ulysse Ateba

AU - Issifou, Saadou

AU - Yazdanbakhsh, Maria

AU - Kremsner, Peter G

N1 - Copyright © 2012. Published by Elsevier Ltd.

PY - 2012

Y1 - 2012

N2 - BACKGROUND: Helminth infections are highly prevalent in the tropics and may have an effect on immune responses to vaccines due to their immunomodulatory effect. The prevalence of helminth infections in young children, the target group for malaria and most other vaccines, is high. Therefore we assessed the influence of helminth infection on vaccine-induced immune responses in a phase I clinical trial of the malaria vaccine candidate GMZ2. METHODS: Twenty Gabonese preschool-age children were vaccinated with GMZ2, a blood stage malaria vaccine candidate. Humoral immune response against the vaccine antigens and parasitological status were assessed. Vaccine-specific antibody concentrations and memory B-cell numbers were compared in worm infected and non-infected participants. RESULTS: Antibody response to GMZ2 was 3.4-fold (95% confidence interval: 1.6, 7.4) higher in Trichuris trichiura negative subjects compared to positive participants, whereas immunoglobulin subclass distribution was similar. Memory B-cell response was moderately increased in T. trichiura negative individuals, although the difference was not significant. CONCLUSIONS: Future malaria vaccine development programs need to account for worm-mediated hyporesponsiveness of immune reactions.

AB - BACKGROUND: Helminth infections are highly prevalent in the tropics and may have an effect on immune responses to vaccines due to their immunomodulatory effect. The prevalence of helminth infections in young children, the target group for malaria and most other vaccines, is high. Therefore we assessed the influence of helminth infection on vaccine-induced immune responses in a phase I clinical trial of the malaria vaccine candidate GMZ2. METHODS: Twenty Gabonese preschool-age children were vaccinated with GMZ2, a blood stage malaria vaccine candidate. Humoral immune response against the vaccine antigens and parasitological status were assessed. Vaccine-specific antibody concentrations and memory B-cell numbers were compared in worm infected and non-infected participants. RESULTS: Antibody response to GMZ2 was 3.4-fold (95% confidence interval: 1.6, 7.4) higher in Trichuris trichiura negative subjects compared to positive participants, whereas immunoglobulin subclass distribution was similar. Memory B-cell response was moderately increased in T. trichiura negative individuals, although the difference was not significant. CONCLUSIONS: Future malaria vaccine development programs need to account for worm-mediated hyporesponsiveness of immune reactions.

U2 - 10.1016/j.vaccine.2012.10.026

DO - 10.1016/j.vaccine.2012.10.026

M3 - Journal article

C2 - 23085365

VL - 30

SP - 7621

EP - 7624

JO - Vaccine

JF - Vaccine

SN - 0264-410X

ER -

ID: 40977111