Profiling the Plasmodium falciparum erythrocyte membrane protein 1-specific immununoglobulin G response among Ghanaian children with hemoglobin S and C
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Profiling the Plasmodium falciparum erythrocyte membrane protein 1-specific immununoglobulin G response among Ghanaian children with hemoglobin S and C. / Oleinikov, Andrew V; Seidu, Zakaria; Oleinikov, Irina V; Tetteh, Mary; Lamptey, Helena; Ofori, Michael F; Hviid, Lars; Lopez-Perez, Mary.
In: The Journal of Infectious Diseases, Vol. 229, No. 1, 2024, p. 203-213.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Profiling the Plasmodium falciparum erythrocyte membrane protein 1-specific immununoglobulin G response among Ghanaian children with hemoglobin S and C
AU - Oleinikov, Andrew V
AU - Seidu, Zakaria
AU - Oleinikov, Irina V
AU - Tetteh, Mary
AU - Lamptey, Helena
AU - Ofori, Michael F
AU - Hviid, Lars
AU - Lopez-Perez, Mary
N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2024
Y1 - 2024
N2 - Members of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are important targets for protective immunity. Abnormal display of PfEMP1 on the surfaces of infected erythrocytes (IEs) and reduced cytoadhesion have been demonstrated in hemoglobin (Hb) AS and HbAC, inherited blood disorders associated with protection against severe P. falciparum malaria. We found that Ghanaian children with HbAS had lower levels of immunoglobulin G against several PfEMP1 variants and that this reactivity increased more slowly with age than in their HbAA counterparts. Moreover, children with HbAS have lower total parasite biomass than those with HbAA at comparable peripheral parasitemias, suggesting impaired cytoadhesion of HbAS IEs in vivo and likely explaining the slower acquisition of PfEMP1-specific immunoglobulin G in this group. In contrast, the function of acquired antibodies was comparable among Hb groups and appears to be intact and sufficient to control parasitemia via opsonization and phagocytosis of IEs.
AB - Members of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are important targets for protective immunity. Abnormal display of PfEMP1 on the surfaces of infected erythrocytes (IEs) and reduced cytoadhesion have been demonstrated in hemoglobin (Hb) AS and HbAC, inherited blood disorders associated with protection against severe P. falciparum malaria. We found that Ghanaian children with HbAS had lower levels of immunoglobulin G against several PfEMP1 variants and that this reactivity increased more slowly with age than in their HbAA counterparts. Moreover, children with HbAS have lower total parasite biomass than those with HbAA at comparable peripheral parasitemias, suggesting impaired cytoadhesion of HbAS IEs in vivo and likely explaining the slower acquisition of PfEMP1-specific immunoglobulin G in this group. In contrast, the function of acquired antibodies was comparable among Hb groups and appears to be intact and sufficient to control parasitemia via opsonization and phagocytosis of IEs.
U2 - 10.1093/infdis/jiad438
DO - 10.1093/infdis/jiad438
M3 - Journal article
C2 - 37804095
VL - 229
SP - 203
EP - 213
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 1
ER -
ID: 379585516