Pre-clinical and clinical development of the first placental malaria vaccine
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Pre-clinical and clinical development of the first placental malaria vaccine. / Pehrson, Caroline; Salanti, Ali; Theander, Thor G; Nielsen, Morten A.
In: Expert Review of Vaccines, Vol. 16, No. 6, 2017, p. 613-624.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Pre-clinical and clinical development of the first placental malaria vaccine
AU - Pehrson, Caroline
AU - Salanti, Ali
AU - Theander, Thor G
AU - Nielsen, Morten A
PY - 2017
Y1 - 2017
N2 - Introduction: Malaria during pregnancy is a massive health problem in endemic areas. Placental malaria infections caused by Plasmodium falciparum are responsible for up to one million babies being born with a low birth weight every year. Significant efforts have been invested into preventing the condition. Areas covered: Pub Med was searched using the broad terms 'malaria parasite placenta' to identify studies of interactions between parasite and host, 'prevention of placental malaria' to identify current strategies to prevent placental malaria, and 'placental malaria vaccine' to identify pre-clinical vaccine development. However, all papers from these searches were not systematically included. Expert commentary: The first phase I clinical trials of vaccines are well underway. Trials testing efficacy are more complicated to carry out as only women that are exposed to parasites during pregnancy will contribute to endpoint measurements, further it may require extensive follow-up to establish protection. Future second generation vaccines may overcome the inherent challenges in making an effective placental malaria vaccine.
AB - Introduction: Malaria during pregnancy is a massive health problem in endemic areas. Placental malaria infections caused by Plasmodium falciparum are responsible for up to one million babies being born with a low birth weight every year. Significant efforts have been invested into preventing the condition. Areas covered: Pub Med was searched using the broad terms 'malaria parasite placenta' to identify studies of interactions between parasite and host, 'prevention of placental malaria' to identify current strategies to prevent placental malaria, and 'placental malaria vaccine' to identify pre-clinical vaccine development. However, all papers from these searches were not systematically included. Expert commentary: The first phase I clinical trials of vaccines are well underway. Trials testing efficacy are more complicated to carry out as only women that are exposed to parasites during pregnancy will contribute to endpoint measurements, further it may require extensive follow-up to establish protection. Future second generation vaccines may overcome the inherent challenges in making an effective placental malaria vaccine.
U2 - 10.1080/14760584.2017.1322512
DO - 10.1080/14760584.2017.1322512
M3 - Journal article
C2 - 28434376
VL - 16
SP - 613
EP - 624
JO - Expert Review of Vaccines
JF - Expert Review of Vaccines
SN - 1476-0584
IS - 6
ER -
ID: 178245907