Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children

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Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children. / Adu, Bright; Dodoo, Daniel; Adukpo, Selorme; Gyan, Ben A; Hedley, Paula L; Goka, Bamenla; Adjei, George O; Larsen, Severin O; Christiansen, Michael; Theisen, Michael.

In: P L o S One, Vol. 6, No. 12, 2011, p. e29465.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Adu, B, Dodoo, D, Adukpo, S, Gyan, BA, Hedley, PL, Goka, B, Adjei, GO, Larsen, SO, Christiansen, M & Theisen, M 2011, 'Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children', P L o S One, vol. 6, no. 12, pp. e29465. https://doi.org/10.1371/journal.pone.0029465

APA

Adu, B., Dodoo, D., Adukpo, S., Gyan, B. A., Hedley, P. L., Goka, B., Adjei, G. O., Larsen, S. O., Christiansen, M., & Theisen, M. (2011). Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children. P L o S One, 6(12), e29465. https://doi.org/10.1371/journal.pone.0029465

Vancouver

Adu B, Dodoo D, Adukpo S, Gyan BA, Hedley PL, Goka B et al. Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children. P L o S One. 2011;6(12):e29465. https://doi.org/10.1371/journal.pone.0029465

Author

Adu, Bright ; Dodoo, Daniel ; Adukpo, Selorme ; Gyan, Ben A ; Hedley, Paula L ; Goka, Bamenla ; Adjei, George O ; Larsen, Severin O ; Christiansen, Michael ; Theisen, Michael. / Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children. In: P L o S One. 2011 ; Vol. 6, No. 12. pp. e29465.

Bibtex

@article{7816f9f3b238435c908e605daa1f5fc0,
title = "Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children",
abstract = "Cerebral malaria (CM) is the most severe outcome of Plasmodium falciparum infection and a major cause of death in children from 2 to 4 years of age. A hospital based study in Ghana showed that P. falciparum induces eosinophilia and found a significantly higher serum level of eosinophil cationic protein (ECP) in CM patients than in uncomplicated malaria (UM) and severe malaria anemia (SA) patients. Single nucleotide polymorphisms (SNPs) have been described in the ECP encoding-gene (RNASE3) of which the c.371G>C polymorphism (rs2073342) results in an arginine to threonine amino acid substitution p.R124T in the polypeptide and abolishes the cytotoxicity of ECP. The present study aimed to investigate the potential association between polymorphisms in RNASE3 and CM.",
author = "Bright Adu and Daniel Dodoo and Selorme Adukpo and Gyan, {Ben A} and Hedley, {Paula L} and Bamenla Goka and Adjei, {George O} and Larsen, {Severin O} and Michael Christiansen and Michael Theisen",
year = "2011",
doi = "10.1371/journal.pone.0029465",
language = "English",
volume = "6",
pages = "e29465",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

RIS

TY - JOUR

T1 - Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children

AU - Adu, Bright

AU - Dodoo, Daniel

AU - Adukpo, Selorme

AU - Gyan, Ben A

AU - Hedley, Paula L

AU - Goka, Bamenla

AU - Adjei, George O

AU - Larsen, Severin O

AU - Christiansen, Michael

AU - Theisen, Michael

PY - 2011

Y1 - 2011

N2 - Cerebral malaria (CM) is the most severe outcome of Plasmodium falciparum infection and a major cause of death in children from 2 to 4 years of age. A hospital based study in Ghana showed that P. falciparum induces eosinophilia and found a significantly higher serum level of eosinophil cationic protein (ECP) in CM patients than in uncomplicated malaria (UM) and severe malaria anemia (SA) patients. Single nucleotide polymorphisms (SNPs) have been described in the ECP encoding-gene (RNASE3) of which the c.371G>C polymorphism (rs2073342) results in an arginine to threonine amino acid substitution p.R124T in the polypeptide and abolishes the cytotoxicity of ECP. The present study aimed to investigate the potential association between polymorphisms in RNASE3 and CM.

AB - Cerebral malaria (CM) is the most severe outcome of Plasmodium falciparum infection and a major cause of death in children from 2 to 4 years of age. A hospital based study in Ghana showed that P. falciparum induces eosinophilia and found a significantly higher serum level of eosinophil cationic protein (ECP) in CM patients than in uncomplicated malaria (UM) and severe malaria anemia (SA) patients. Single nucleotide polymorphisms (SNPs) have been described in the ECP encoding-gene (RNASE3) of which the c.371G>C polymorphism (rs2073342) results in an arginine to threonine amino acid substitution p.R124T in the polypeptide and abolishes the cytotoxicity of ECP. The present study aimed to investigate the potential association between polymorphisms in RNASE3 and CM.

U2 - 10.1371/journal.pone.0029465

DO - 10.1371/journal.pone.0029465

M3 - Journal article

C2 - 22216286

VL - 6

SP - e29465

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 12

ER -

ID: 36041780