Physiological adaption to maternal malaria and other adverse exposure: low birth weight, functional capacity, and possible metabolic disease in adult life
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Physiological adaption to maternal malaria and other adverse exposure : low birth weight, functional capacity, and possible metabolic disease in adult life. / Christensen, Dirk L; Kapur, Anil; Bygbjerg, Ib C.
In: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, Vol. 115 Suppl 1, 2011, p. S16-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Physiological adaption to maternal malaria and other adverse exposure
T2 - low birth weight, functional capacity, and possible metabolic disease in adult life
AU - Christensen, Dirk L
AU - Kapur, Anil
AU - Bygbjerg, Ib C
N1 - Copyright © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd.. All rights reserved.
PY - 2011
Y1 - 2011
N2 - The concept of developmental origins of health and disease and the epidemic of noncommunicable diseases in low- and middle-income countries has increased the focus on low birth weight (LBW). Most studies linking LBW to future risk of metabolic diseases have focused on maternal nutrition and anemia. Several studies have shown that LBWis linked to skeletal muscle insulin resistance and future risk of type 2 diabetes, possibly caused by permanent modifications in skeletal muscle morphology and biochemistry leading to lowered functional capacity and physical activity in adult life. In some parts of the world, malaria infection during pregnancy is the most common cause of anemia and LBW. By causing disruption to nutrient supply, as well as hypoxia, placental malaria and anemia negatively impact intrauterine fetal development. Thus, in utero exposure to placental malaria and consequent LBW may impart a higher risk of developing type 2 diabetes in early adult life. This has not been investigated systematically. Worldwide, an estimated 125 million pregnancies occur annually in malarial areas with a vast potential for intrauterine growth restriction, LBW, and subsequent risk of metabolic dysfunction, including type 2 diabetes; this potential link also opens an opportunity for early prevention of future metabolic diseases by paying greater attention to malaria during pregnancy.
AB - The concept of developmental origins of health and disease and the epidemic of noncommunicable diseases in low- and middle-income countries has increased the focus on low birth weight (LBW). Most studies linking LBW to future risk of metabolic diseases have focused on maternal nutrition and anemia. Several studies have shown that LBWis linked to skeletal muscle insulin resistance and future risk of type 2 diabetes, possibly caused by permanent modifications in skeletal muscle morphology and biochemistry leading to lowered functional capacity and physical activity in adult life. In some parts of the world, malaria infection during pregnancy is the most common cause of anemia and LBW. By causing disruption to nutrient supply, as well as hypoxia, placental malaria and anemia negatively impact intrauterine fetal development. Thus, in utero exposure to placental malaria and consequent LBW may impart a higher risk of developing type 2 diabetes in early adult life. This has not been investigated systematically. Worldwide, an estimated 125 million pregnancies occur annually in malarial areas with a vast potential for intrauterine growth restriction, LBW, and subsequent risk of metabolic dysfunction, including type 2 diabetes; this potential link also opens an opportunity for early prevention of future metabolic diseases by paying greater attention to malaria during pregnancy.
KW - Adaptation, Physiological
KW - Adult
KW - Anemia
KW - Diabetes Mellitus, Type 2
KW - Female
KW - Fetal Growth Retardation
KW - Humans
KW - Infant, Low Birth Weight
KW - Infant, Newborn
KW - Malaria
KW - Male
KW - Malnutrition
KW - Maternal Welfare
KW - Metabolic Diseases
KW - Muscle, Skeletal
KW - Pregnancy
KW - Pregnancy Complications, Parasitic
KW - Prenatal Exposure Delayed Effects
U2 - 10.1016/S0020-7292(11)60006-4
DO - 10.1016/S0020-7292(11)60006-4
M3 - Journal article
C2 - 22099434
VL - 115 Suppl 1
SP - S16-9
JO - International Journal of Gynecology & Obstetrics
JF - International Journal of Gynecology & Obstetrics
SN - 0020-7292
ER -
ID: 38073706