Neutrophil alterations in pregnancy-associated malaria and induction of neutrophil chemotaxis by Plasmodium falciparum

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Neutrophil alterations in pregnancy-associated malaria and induction of neutrophil chemotaxis by Plasmodium falciparum. / Boström, S.; Schmiegelow, C; Abu Abed, U; Minja, D T R; Lusingu, J; Brinkmann, V; Honkpehedji, Y J; Loembe, M M; Adegnika, Ayola Akim; Mordmüller, Benjamin; Troye-Blomberg, M; Amulic, Borko.

In: Parasite Immunology, Vol. 39, No. 6, e12433, 2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Boström, S, Schmiegelow, C, Abu Abed, U, Minja, DTR, Lusingu, J, Brinkmann, V, Honkpehedji, YJ, Loembe, MM, Adegnika, AA, Mordmüller, B, Troye-Blomberg, M & Amulic, B 2017, 'Neutrophil alterations in pregnancy-associated malaria and induction of neutrophil chemotaxis by Plasmodium falciparum', Parasite Immunology, vol. 39, no. 6, e12433. https://doi.org/10.1111/pim.12433

APA

Boström, S., Schmiegelow, C., Abu Abed, U., Minja, D. T. R., Lusingu, J., Brinkmann, V., Honkpehedji, Y. J., Loembe, M. M., Adegnika, A. A., Mordmüller, B., Troye-Blomberg, M., & Amulic, B. (2017). Neutrophil alterations in pregnancy-associated malaria and induction of neutrophil chemotaxis by Plasmodium falciparum. Parasite Immunology, 39(6), [e12433]. https://doi.org/10.1111/pim.12433

Vancouver

Boström S, Schmiegelow C, Abu Abed U, Minja DTR, Lusingu J, Brinkmann V et al. Neutrophil alterations in pregnancy-associated malaria and induction of neutrophil chemotaxis by Plasmodium falciparum. Parasite Immunology. 2017;39(6). e12433. https://doi.org/10.1111/pim.12433

Author

Boström, S. ; Schmiegelow, C ; Abu Abed, U ; Minja, D T R ; Lusingu, J ; Brinkmann, V ; Honkpehedji, Y J ; Loembe, M M ; Adegnika, Ayola Akim ; Mordmüller, Benjamin ; Troye-Blomberg, M ; Amulic, Borko. / Neutrophil alterations in pregnancy-associated malaria and induction of neutrophil chemotaxis by Plasmodium falciparum. In: Parasite Immunology. 2017 ; Vol. 39, No. 6.

Bibtex

@article{cf88dbd9faa24e7fbc7d205aefa04462,
title = "Neutrophil alterations in pregnancy-associated malaria and induction of neutrophil chemotaxis by Plasmodium falciparum",
abstract = "Pregnancy-associated malaria (PAM) is a severe form of the disease caused by sequestration of Plasmodium falciparum-infected red blood cells (iRBCs) in the developing placenta. Pathogenesis of PAM is partially based on immunopathology, with frequent monocyte infiltration into the placenta. Neutrophils are abundant blood cells that are essential for immune defence but may also cause inflammatory pathology. Their role in PAM remains unclear. We analysed neutrophil alterations in the context of PAM to better understand their contribution to disease development. Pregnant women exposed to Plasmodium falciparum had decreased numbers of circulating neutrophils. Placental-like BeWo cells stimulated with malaria parasites produced the neutrophil chemoattractant IL-8 and recruited neutrophils in a trans-well assay. Finally, immunostaining of a PAM placenta confirmed neutrophil accumulation in the intervillous space. Our data indicate neutrophils may play a role in placental malaria and should be more closely examined as an etiological agent in the pathophysiology of disease.",
author = "S. Bostr{\"o}m and C Schmiegelow and {Abu Abed}, U and Minja, {D T R} and J Lusingu and V Brinkmann and Honkpehedji, {Y J} and Loembe, {M M} and Adegnika, {Ayola Akim} and Benjamin Mordm{\"u}ller and M Troye-Blomberg and Borko Amulic",
note = "{\textcopyright} 2017 John Wiley & Sons Ltd.",
year = "2017",
doi = "10.1111/pim.12433",
language = "English",
volume = "39",
journal = "Parasite Immunology",
issn = "0141-9838",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Neutrophil alterations in pregnancy-associated malaria and induction of neutrophil chemotaxis by Plasmodium falciparum

AU - Boström, S.

AU - Schmiegelow, C

AU - Abu Abed, U

AU - Minja, D T R

AU - Lusingu, J

AU - Brinkmann, V

AU - Honkpehedji, Y J

AU - Loembe, M M

AU - Adegnika, Ayola Akim

AU - Mordmüller, Benjamin

AU - Troye-Blomberg, M

AU - Amulic, Borko

N1 - © 2017 John Wiley & Sons Ltd.

PY - 2017

Y1 - 2017

N2 - Pregnancy-associated malaria (PAM) is a severe form of the disease caused by sequestration of Plasmodium falciparum-infected red blood cells (iRBCs) in the developing placenta. Pathogenesis of PAM is partially based on immunopathology, with frequent monocyte infiltration into the placenta. Neutrophils are abundant blood cells that are essential for immune defence but may also cause inflammatory pathology. Their role in PAM remains unclear. We analysed neutrophil alterations in the context of PAM to better understand their contribution to disease development. Pregnant women exposed to Plasmodium falciparum had decreased numbers of circulating neutrophils. Placental-like BeWo cells stimulated with malaria parasites produced the neutrophil chemoattractant IL-8 and recruited neutrophils in a trans-well assay. Finally, immunostaining of a PAM placenta confirmed neutrophil accumulation in the intervillous space. Our data indicate neutrophils may play a role in placental malaria and should be more closely examined as an etiological agent in the pathophysiology of disease.

AB - Pregnancy-associated malaria (PAM) is a severe form of the disease caused by sequestration of Plasmodium falciparum-infected red blood cells (iRBCs) in the developing placenta. Pathogenesis of PAM is partially based on immunopathology, with frequent monocyte infiltration into the placenta. Neutrophils are abundant blood cells that are essential for immune defence but may also cause inflammatory pathology. Their role in PAM remains unclear. We analysed neutrophil alterations in the context of PAM to better understand their contribution to disease development. Pregnant women exposed to Plasmodium falciparum had decreased numbers of circulating neutrophils. Placental-like BeWo cells stimulated with malaria parasites produced the neutrophil chemoattractant IL-8 and recruited neutrophils in a trans-well assay. Finally, immunostaining of a PAM placenta confirmed neutrophil accumulation in the intervillous space. Our data indicate neutrophils may play a role in placental malaria and should be more closely examined as an etiological agent in the pathophysiology of disease.

U2 - 10.1111/pim.12433

DO - 10.1111/pim.12433

M3 - Journal article

C2 - 28380252

VL - 39

JO - Parasite Immunology

JF - Parasite Immunology

SN - 0141-9838

IS - 6

M1 - e12433

ER -

ID: 178807041