Neonatal mortality risk of vulnerable newborns by fine stratum of gestational age and birthweight for 230 679 live births in nine low- and middle-income countries, 2000–2017

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Neonatal mortality risk of vulnerable newborns by fine stratum of gestational age and birthweight for 230 679 live births in nine low- and middle-income countries, 2000–2017. / Hazel, Elizabeth A.; Erchick, Daniel J.; Katz, Joanne; Lee, Anne C.C.; Diaz, Michael; Wu, Lee S.F.; West, Keith P.; Shamim, Abu Ahmed; Christian, Parul; Ali, Hasmot; Baqui, Abdullah H.; Saha, Samir K.; Ahmed, Salahuddin; Roy, Arunangshu Dutta; Silveira, Mariângela F.; Buffarini, Romina; Shapiro, Roger; Zash, Rebecca; Kolsteren, Patrick; Lachat, Carl; Huybregts, Lieven; Roberfroid, Dominique; Zhu, Zhonghai; Zeng, Lingxia; Gebreyesus, Seifu H.; Tesfamariam, Kokeb; Adu-Afarwuah, Seth; Dewey, Kathryn G.; Gyaase, Stephaney; Poku-Asante, Kwaku; Boamah Kaali, Ellen; Jack, Darby; Ravilla, Thulasiraj; Tielsch, James; Taneja, Sunita; Chowdhury, Ranadip; Ashorn, Per; Maleta, Kenneth; Ashorn, Ulla; Mangani, Charles; Mullany, Luke C.; Khatry, Subarna K.; Ramokolo, Vundli; Zembe-Mkabile, Wanga; Fawzi, Wafaie W.; Wang, Dongqing; Schmiegelow, Christentze; Msemo, Omari Abdul; Minja, Daniel; Lusingu, John P.A.; Smith, Emily R.; Masanja, Honorati; Mongkolchati, Aroonsri; Keentupthai, Paniya; Kakuru, Abel; Kajubi, Richard; Semrau, Katherine; Hamer, Davidson H.; Manasyan, Albert; Pry, Jake M.; Chasekwa, Bernard; Humphrey, Jean; Black, Robert E.

In: BJOG: An International Journal of Obstetrics and Gynaecology, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hazel, EA, Erchick, DJ, Katz, J, Lee, ACC, Diaz, M, Wu, LSF, West, KP, Shamim, AA, Christian, P, Ali, H, Baqui, AH, Saha, SK, Ahmed, S, Roy, AD, Silveira, MF, Buffarini, R, Shapiro, R, Zash, R, Kolsteren, P, Lachat, C, Huybregts, L, Roberfroid, D, Zhu, Z, Zeng, L, Gebreyesus, SH, Tesfamariam, K, Adu-Afarwuah, S, Dewey, KG, Gyaase, S, Poku-Asante, K, Boamah Kaali, E, Jack, D, Ravilla, T, Tielsch, J, Taneja, S, Chowdhury, R, Ashorn, P, Maleta, K, Ashorn, U, Mangani, C, Mullany, LC, Khatry, SK, Ramokolo, V, Zembe-Mkabile, W, Fawzi, WW, Wang, D, Schmiegelow, C, Msemo, OA, Minja, D, Lusingu, JPA, Smith, ER, Masanja, H, Mongkolchati, A, Keentupthai, P, Kakuru, A, Kajubi, R, Semrau, K, Hamer, DH, Manasyan, A, Pry, JM, Chasekwa, B, Humphrey, J & Black, RE 2024, 'Neonatal mortality risk of vulnerable newborns by fine stratum of gestational age and birthweight for 230 679 live births in nine low- and middle-income countries, 2000–2017', BJOG: An International Journal of Obstetrics and Gynaecology. https://doi.org/10.1111/1471-0528.17743

APA

Hazel, E. A., Erchick, D. J., Katz, J., Lee, A. C. C., Diaz, M., Wu, L. S. F., West, K. P., Shamim, A. A., Christian, P., Ali, H., Baqui, A. H., Saha, S. K., Ahmed, S., Roy, A. D., Silveira, M. F., Buffarini, R., Shapiro, R., Zash, R., Kolsteren, P., ... Black, R. E. (2024). Neonatal mortality risk of vulnerable newborns by fine stratum of gestational age and birthweight for 230 679 live births in nine low- and middle-income countries, 2000–2017. BJOG: An International Journal of Obstetrics and Gynaecology. https://doi.org/10.1111/1471-0528.17743

Vancouver

Hazel EA, Erchick DJ, Katz J, Lee ACC, Diaz M, Wu LSF et al. Neonatal mortality risk of vulnerable newborns by fine stratum of gestational age and birthweight for 230 679 live births in nine low- and middle-income countries, 2000–2017. BJOG: An International Journal of Obstetrics and Gynaecology. 2024. https://doi.org/10.1111/1471-0528.17743

Author

Hazel, Elizabeth A. ; Erchick, Daniel J. ; Katz, Joanne ; Lee, Anne C.C. ; Diaz, Michael ; Wu, Lee S.F. ; West, Keith P. ; Shamim, Abu Ahmed ; Christian, Parul ; Ali, Hasmot ; Baqui, Abdullah H. ; Saha, Samir K. ; Ahmed, Salahuddin ; Roy, Arunangshu Dutta ; Silveira, Mariângela F. ; Buffarini, Romina ; Shapiro, Roger ; Zash, Rebecca ; Kolsteren, Patrick ; Lachat, Carl ; Huybregts, Lieven ; Roberfroid, Dominique ; Zhu, Zhonghai ; Zeng, Lingxia ; Gebreyesus, Seifu H. ; Tesfamariam, Kokeb ; Adu-Afarwuah, Seth ; Dewey, Kathryn G. ; Gyaase, Stephaney ; Poku-Asante, Kwaku ; Boamah Kaali, Ellen ; Jack, Darby ; Ravilla, Thulasiraj ; Tielsch, James ; Taneja, Sunita ; Chowdhury, Ranadip ; Ashorn, Per ; Maleta, Kenneth ; Ashorn, Ulla ; Mangani, Charles ; Mullany, Luke C. ; Khatry, Subarna K. ; Ramokolo, Vundli ; Zembe-Mkabile, Wanga ; Fawzi, Wafaie W. ; Wang, Dongqing ; Schmiegelow, Christentze ; Msemo, Omari Abdul ; Minja, Daniel ; Lusingu, John P.A. ; Smith, Emily R. ; Masanja, Honorati ; Mongkolchati, Aroonsri ; Keentupthai, Paniya ; Kakuru, Abel ; Kajubi, Richard ; Semrau, Katherine ; Hamer, Davidson H. ; Manasyan, Albert ; Pry, Jake M. ; Chasekwa, Bernard ; Humphrey, Jean ; Black, Robert E. / Neonatal mortality risk of vulnerable newborns by fine stratum of gestational age and birthweight for 230 679 live births in nine low- and middle-income countries, 2000–2017. In: BJOG: An International Journal of Obstetrics and Gynaecology. 2024.

Bibtex

@article{e8d3faad84bf4eed91c21c9373b2b7db,
title = "Neonatal mortality risk of vulnerable newborns by fine stratum of gestational age and birthweight for 230 679 live births in nine low- and middle-income countries, 2000–2017",
abstract = "Objective: To describe the mortality risks by fine strata of gestational age and birthweight among 230 679 live births in nine low- and middle-income countries (LMICs) from 2000 to 2017. Design: Descriptive multi-country secondary data analysis. Setting: Nine LMICs in sub-Saharan Africa, Southern and Eastern Asia, and Latin America. Population: Liveborn infants from 15 population-based cohorts. Methods: Subnational, population-based studies with high-quality birth outcome data were invited to join the Vulnerable Newborn Measurement Collaboration. All studies included birthweight, gestational age measured by ultrasound or last menstrual period, infant sex and neonatal survival. We defined adequate birthweight as 2500–3999 g (reference category), macrosomia as ≥4000 g, moderate low as 1500–2499 g and very low birthweight as <1500 g. We analysed fine strata classifications of preterm, term and post-term: ≥42+0, 39+0–41+6 (reference category), 37+0–38+6, 34+0–36+6,34+0–36+6,32+0–33+6, 30+0–31+6, 28+0–29+6 and less than 28 weeks. Main outcome measures: Median and interquartile ranges by study for neonatal mortality rates (NMR) and relative risks (RR). We also performed meta-analysis for the relative mortality risks with 95% confidence intervals (CIs) by the fine categories, stratified by regional study setting (sub-Saharan Africa and Southern Asia) and study-level NMR (≤25 versus >25 neonatal deaths per 1000 live births). Results: We found a dose–response relationship between lower gestational ages and birthweights with increasing neonatal mortality risks. The highest NMR and RR were among preterm babies born at <28 weeks (median NMR 359.2 per 1000 live births; RR 18.0, 95% CI 8.6–37.6) and very low birthweight (462.8 per 1000 live births; RR 43.4, 95% CI 29.5–63.9). We found no statistically significant neonatal mortality risk for macrosomia (RR 1.1, 95% CI 0.6–3.0) but a statistically significant risk for all preterm babies, post-term babies (RR 1.3, 95% CI 1.1–1.5) and babies born at 370–386 weeks (RR 1.2, 95% CI 1.0–1.4). There were no statistically significant differences by region or underlying neonatal mortality. Conclusions: In addition to tracking vulnerable newborn types, monitoring finer categories of birthweight and gestational age will allow for better understanding of the predictors, interventions and health outcomes for vulnerable newborns. It is imperative that all newborns from live births and stillbirths have an accurate recorded weight and gestational age to track maternal and neonatal health and optimise prevention and care of vulnerable newborns.",
keywords = "low birthweight, newborn, preterm birth",
author = "Hazel, {Elizabeth A.} and Erchick, {Daniel J.} and Joanne Katz and Lee, {Anne C.C.} and Michael Diaz and Wu, {Lee S.F.} and West, {Keith P.} and Shamim, {Abu Ahmed} and Parul Christian and Hasmot Ali and Baqui, {Abdullah H.} and Saha, {Samir K.} and Salahuddin Ahmed and Roy, {Arunangshu Dutta} and Silveira, {Mari{\^a}ngela F.} and Romina Buffarini and Roger Shapiro and Rebecca Zash and Patrick Kolsteren and Carl Lachat and Lieven Huybregts and Dominique Roberfroid and Zhonghai Zhu and Lingxia Zeng and Gebreyesus, {Seifu H.} and Kokeb Tesfamariam and Seth Adu-Afarwuah and Dewey, {Kathryn G.} and Stephaney Gyaase and Kwaku Poku-Asante and Ellen Boamah Kaali and Darby Jack and Thulasiraj Ravilla and James Tielsch and Sunita Taneja and Ranadip Chowdhury and Per Ashorn and Kenneth Maleta and Ulla Ashorn and Charles Mangani and Mullany, {Luke C.} and Khatry, {Subarna K.} and Vundli Ramokolo and Wanga Zembe-Mkabile and Fawzi, {Wafaie W.} and Dongqing Wang and Christentze Schmiegelow and Msemo, {Omari Abdul} and Daniel Minja and Lusingu, {John P.A.} and Smith, {Emily R.} and Honorati Masanja and Aroonsri Mongkolchati and Paniya Keentupthai and Abel Kakuru and Richard Kajubi and Katherine Semrau and Hamer, {Davidson H.} and Albert Manasyan and Pry, {Jake M.} and Bernard Chasekwa and Jean Humphrey and Black, {Robert E.}",
note = "Publisher Copyright: {\textcopyright} 2024 John Wiley & Sons Ltd.",
year = "2024",
doi = "10.1111/1471-0528.17743",
language = "English",
journal = "British Journal of Obstetrics and Gynaecology, Supplement",
issn = "0140-7686",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Neonatal mortality risk of vulnerable newborns by fine stratum of gestational age and birthweight for 230 679 live births in nine low- and middle-income countries, 2000–2017

AU - Hazel, Elizabeth A.

AU - Erchick, Daniel J.

AU - Katz, Joanne

AU - Lee, Anne C.C.

AU - Diaz, Michael

AU - Wu, Lee S.F.

AU - West, Keith P.

AU - Shamim, Abu Ahmed

AU - Christian, Parul

AU - Ali, Hasmot

AU - Baqui, Abdullah H.

AU - Saha, Samir K.

AU - Ahmed, Salahuddin

AU - Roy, Arunangshu Dutta

AU - Silveira, Mariângela F.

AU - Buffarini, Romina

AU - Shapiro, Roger

AU - Zash, Rebecca

AU - Kolsteren, Patrick

AU - Lachat, Carl

AU - Huybregts, Lieven

AU - Roberfroid, Dominique

AU - Zhu, Zhonghai

AU - Zeng, Lingxia

AU - Gebreyesus, Seifu H.

AU - Tesfamariam, Kokeb

AU - Adu-Afarwuah, Seth

AU - Dewey, Kathryn G.

AU - Gyaase, Stephaney

AU - Poku-Asante, Kwaku

AU - Boamah Kaali, Ellen

AU - Jack, Darby

AU - Ravilla, Thulasiraj

AU - Tielsch, James

AU - Taneja, Sunita

AU - Chowdhury, Ranadip

AU - Ashorn, Per

AU - Maleta, Kenneth

AU - Ashorn, Ulla

AU - Mangani, Charles

AU - Mullany, Luke C.

AU - Khatry, Subarna K.

AU - Ramokolo, Vundli

AU - Zembe-Mkabile, Wanga

AU - Fawzi, Wafaie W.

AU - Wang, Dongqing

AU - Schmiegelow, Christentze

AU - Msemo, Omari Abdul

AU - Minja, Daniel

AU - Lusingu, John P.A.

AU - Smith, Emily R.

AU - Masanja, Honorati

AU - Mongkolchati, Aroonsri

AU - Keentupthai, Paniya

AU - Kakuru, Abel

AU - Kajubi, Richard

AU - Semrau, Katherine

AU - Hamer, Davidson H.

AU - Manasyan, Albert

AU - Pry, Jake M.

AU - Chasekwa, Bernard

AU - Humphrey, Jean

AU - Black, Robert E.

N1 - Publisher Copyright: © 2024 John Wiley & Sons Ltd.

PY - 2024

Y1 - 2024

N2 - Objective: To describe the mortality risks by fine strata of gestational age and birthweight among 230 679 live births in nine low- and middle-income countries (LMICs) from 2000 to 2017. Design: Descriptive multi-country secondary data analysis. Setting: Nine LMICs in sub-Saharan Africa, Southern and Eastern Asia, and Latin America. Population: Liveborn infants from 15 population-based cohorts. Methods: Subnational, population-based studies with high-quality birth outcome data were invited to join the Vulnerable Newborn Measurement Collaboration. All studies included birthweight, gestational age measured by ultrasound or last menstrual period, infant sex and neonatal survival. We defined adequate birthweight as 2500–3999 g (reference category), macrosomia as ≥4000 g, moderate low as 1500–2499 g and very low birthweight as <1500 g. We analysed fine strata classifications of preterm, term and post-term: ≥42+0, 39+0–41+6 (reference category), 37+0–38+6, 34+0–36+6,34+0–36+6,32+0–33+6, 30+0–31+6, 28+0–29+6 and less than 28 weeks. Main outcome measures: Median and interquartile ranges by study for neonatal mortality rates (NMR) and relative risks (RR). We also performed meta-analysis for the relative mortality risks with 95% confidence intervals (CIs) by the fine categories, stratified by regional study setting (sub-Saharan Africa and Southern Asia) and study-level NMR (≤25 versus >25 neonatal deaths per 1000 live births). Results: We found a dose–response relationship between lower gestational ages and birthweights with increasing neonatal mortality risks. The highest NMR and RR were among preterm babies born at <28 weeks (median NMR 359.2 per 1000 live births; RR 18.0, 95% CI 8.6–37.6) and very low birthweight (462.8 per 1000 live births; RR 43.4, 95% CI 29.5–63.9). We found no statistically significant neonatal mortality risk for macrosomia (RR 1.1, 95% CI 0.6–3.0) but a statistically significant risk for all preterm babies, post-term babies (RR 1.3, 95% CI 1.1–1.5) and babies born at 370–386 weeks (RR 1.2, 95% CI 1.0–1.4). There were no statistically significant differences by region or underlying neonatal mortality. Conclusions: In addition to tracking vulnerable newborn types, monitoring finer categories of birthweight and gestational age will allow for better understanding of the predictors, interventions and health outcomes for vulnerable newborns. It is imperative that all newborns from live births and stillbirths have an accurate recorded weight and gestational age to track maternal and neonatal health and optimise prevention and care of vulnerable newborns.

AB - Objective: To describe the mortality risks by fine strata of gestational age and birthweight among 230 679 live births in nine low- and middle-income countries (LMICs) from 2000 to 2017. Design: Descriptive multi-country secondary data analysis. Setting: Nine LMICs in sub-Saharan Africa, Southern and Eastern Asia, and Latin America. Population: Liveborn infants from 15 population-based cohorts. Methods: Subnational, population-based studies with high-quality birth outcome data were invited to join the Vulnerable Newborn Measurement Collaboration. All studies included birthweight, gestational age measured by ultrasound or last menstrual period, infant sex and neonatal survival. We defined adequate birthweight as 2500–3999 g (reference category), macrosomia as ≥4000 g, moderate low as 1500–2499 g and very low birthweight as <1500 g. We analysed fine strata classifications of preterm, term and post-term: ≥42+0, 39+0–41+6 (reference category), 37+0–38+6, 34+0–36+6,34+0–36+6,32+0–33+6, 30+0–31+6, 28+0–29+6 and less than 28 weeks. Main outcome measures: Median and interquartile ranges by study for neonatal mortality rates (NMR) and relative risks (RR). We also performed meta-analysis for the relative mortality risks with 95% confidence intervals (CIs) by the fine categories, stratified by regional study setting (sub-Saharan Africa and Southern Asia) and study-level NMR (≤25 versus >25 neonatal deaths per 1000 live births). Results: We found a dose–response relationship between lower gestational ages and birthweights with increasing neonatal mortality risks. The highest NMR and RR were among preterm babies born at <28 weeks (median NMR 359.2 per 1000 live births; RR 18.0, 95% CI 8.6–37.6) and very low birthweight (462.8 per 1000 live births; RR 43.4, 95% CI 29.5–63.9). We found no statistically significant neonatal mortality risk for macrosomia (RR 1.1, 95% CI 0.6–3.0) but a statistically significant risk for all preterm babies, post-term babies (RR 1.3, 95% CI 1.1–1.5) and babies born at 370–386 weeks (RR 1.2, 95% CI 1.0–1.4). There were no statistically significant differences by region or underlying neonatal mortality. Conclusions: In addition to tracking vulnerable newborn types, monitoring finer categories of birthweight and gestational age will allow for better understanding of the predictors, interventions and health outcomes for vulnerable newborns. It is imperative that all newborns from live births and stillbirths have an accurate recorded weight and gestational age to track maternal and neonatal health and optimise prevention and care of vulnerable newborns.

KW - low birthweight

KW - newborn

KW - preterm birth

UR - http://www.scopus.com/inward/record.url?scp=85182491431&partnerID=8YFLogxK

U2 - 10.1111/1471-0528.17743

DO - 10.1111/1471-0528.17743

M3 - Journal article

C2 - 38228570

AN - SCOPUS:85182491431

JO - British Journal of Obstetrics and Gynaecology, Supplement

JF - British Journal of Obstetrics and Gynaecology, Supplement

SN - 0140-7686

ER -

ID: 381849046