Natural acquired immunity to malaria antigens among pregnant women with hemoglobin C trait

Research output: Contribution to journal › Journal article › Research › peer-review

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Natural acquired immunity to malaria antigens among pregnant women with hemoglobin C trait. / Lopez-Perez, Mary; Viwami, Firmine; Doritchamou, Justin; Ndam, Nicaise Tuikue; Hviid, Lars.

In: American Journal of Tropical Medicine and Hygiene, Vol. 106, No. 3, 2022, p. 853–856.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lopez-Perez, M, Viwami, F, Doritchamou, J, Ndam, NT & Hviid, L 2022, 'Natural acquired immunity to malaria antigens among pregnant women with hemoglobin C trait', American Journal of Tropical Medicine and Hygiene, vol. 106, no. 3, pp. 853–856. https://doi.org/10.4269/ajtmh.21-1039

APA

Lopez-Perez, M., Viwami, F., Doritchamou, J., Ndam, N. T., & Hviid, L. (2022). Natural acquired immunity to malaria antigens among pregnant women with hemoglobin C trait. American Journal of Tropical Medicine and Hygiene, 106(3), 853–856. https://doi.org/10.4269/ajtmh.21-1039

Vancouver

Lopez-Perez M, Viwami F, Doritchamou J, Ndam NT, Hviid L. Natural acquired immunity to malaria antigens among pregnant women with hemoglobin C trait. American Journal of Tropical Medicine and Hygiene. 2022;106(3):853–856. https://doi.org/10.4269/ajtmh.21-1039

Author

Lopez-Perez, Mary ; Viwami, Firmine ; Doritchamou, Justin ; Ndam, Nicaise Tuikue ; Hviid, Lars. / Natural acquired immunity to malaria antigens among pregnant women with hemoglobin C trait. In: American Journal of Tropical Medicine and Hygiene. 2022 ; Vol. 106, No. 3. pp. 853–856.

Bibtex

@article{6ea53e670ae34f7cb44abd324113c481,
title = "Natural acquired immunity to malaria antigens among pregnant women with hemoglobin C trait",
abstract = "Hemoglobin C is the second most common structural hemoglobinopathy in Africa, and carriers have a reduced risk of severe malaria. However, the effect of HbAC on the antibody response to malaria antigens in pregnancy has not been studied. Here, we measured PfEMP1-specific antibodCLUR in plasma samples from 74 Beninese pregnant women with either HbAA or HbAC. IgG-mediated inhibition of VAR2CSA+ infected erythrocytes adhesion to chondroitin sulfate A (CSA) was also tested. PfEMP1-specific IgG levels to VAR2CSA were significantly lower in HbAC women, suggesting less exposure to VAR2CSA. In contrast, the percentage of VAR2CSA+-infected erythrocytes adhesion to CSA was not different between HbAA and HbAC women. Moreover, IgG levels to PfEMP1 variants associated with severe malaria were not significantly different between groups. The findings indicate similar exposure to Plasmodium falciparum parasites expressing PfEMP1 variants causing severe malaria, and justify more comprehensive studies of hemoglobinopathy-related qualitative and quantitative differences in PfEMP1-specific antibody responses.",
author = "Mary Lopez-Perez and Firmine Viwami and Justin Doritchamou and Ndam, {Nicaise Tuikue} and Lars Hviid",
year = "2022",
doi = "10.4269/ajtmh.21-1039",
language = "English",
volume = "106",
pages = "853–856",
journal = "Journal. National Malaria Society",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "3",

}

RIS

TY - JOUR

T1 - Natural acquired immunity to malaria antigens among pregnant women with hemoglobin C trait

AU - Lopez-Perez, Mary

AU - Viwami, Firmine

AU - Doritchamou, Justin

AU - Ndam, Nicaise Tuikue

AU - Hviid, Lars

PY - 2022

Y1 - 2022

N2 - Hemoglobin C is the second most common structural hemoglobinopathy in Africa, and carriers have a reduced risk of severe malaria. However, the effect of HbAC on the antibody response to malaria antigens in pregnancy has not been studied. Here, we measured PfEMP1-specific antibodCLUR in plasma samples from 74 Beninese pregnant women with either HbAA or HbAC. IgG-mediated inhibition of VAR2CSA+ infected erythrocytes adhesion to chondroitin sulfate A (CSA) was also tested. PfEMP1-specific IgG levels to VAR2CSA were significantly lower in HbAC women, suggesting less exposure to VAR2CSA. In contrast, the percentage of VAR2CSA+-infected erythrocytes adhesion to CSA was not different between HbAA and HbAC women. Moreover, IgG levels to PfEMP1 variants associated with severe malaria were not significantly different between groups. The findings indicate similar exposure to Plasmodium falciparum parasites expressing PfEMP1 variants causing severe malaria, and justify more comprehensive studies of hemoglobinopathy-related qualitative and quantitative differences in PfEMP1-specific antibody responses.

AB - Hemoglobin C is the second most common structural hemoglobinopathy in Africa, and carriers have a reduced risk of severe malaria. However, the effect of HbAC on the antibody response to malaria antigens in pregnancy has not been studied. Here, we measured PfEMP1-specific antibodCLUR in plasma samples from 74 Beninese pregnant women with either HbAA or HbAC. IgG-mediated inhibition of VAR2CSA+ infected erythrocytes adhesion to chondroitin sulfate A (CSA) was also tested. PfEMP1-specific IgG levels to VAR2CSA were significantly lower in HbAC women, suggesting less exposure to VAR2CSA. In contrast, the percentage of VAR2CSA+-infected erythrocytes adhesion to CSA was not different between HbAA and HbAC women. Moreover, IgG levels to PfEMP1 variants associated with severe malaria were not significantly different between groups. The findings indicate similar exposure to Plasmodium falciparum parasites expressing PfEMP1 variants causing severe malaria, and justify more comprehensive studies of hemoglobinopathy-related qualitative and quantitative differences in PfEMP1-specific antibody responses.

U2 - 10.4269/ajtmh.21-1039

DO - 10.4269/ajtmh.21-1039

M3 - Journal article

C2 - 35026728

VL - 106

SP - 853

EP - 856

JO - Journal. National Malaria Society

JF - Journal. National Malaria Society

SN - 0002-9637

IS - 3

ER -

ID: 291018552