Monitoring antifolate resistance in intermittent preventive therapy for malaria

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Standard

Monitoring antifolate resistance in intermittent preventive therapy for malaria. / Venkatesan, Meera; Alifrangis, Michael; Roper, Cally; Plowe, Christopher V.

In: Trends in Parasitology, Vol. 29, No. 10, 10.2013, p. 497-504.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Venkatesan, M, Alifrangis, M, Roper, C & Plowe, CV 2013, 'Monitoring antifolate resistance in intermittent preventive therapy for malaria', Trends in Parasitology, vol. 29, no. 10, pp. 497-504. https://doi.org/10.1016/j.pt.2013.07.008

APA

Venkatesan, M., Alifrangis, M., Roper, C., & Plowe, C. V. (2013). Monitoring antifolate resistance in intermittent preventive therapy for malaria. Trends in Parasitology, 29(10), 497-504. https://doi.org/10.1016/j.pt.2013.07.008

Vancouver

Venkatesan M, Alifrangis M, Roper C, Plowe CV. Monitoring antifolate resistance in intermittent preventive therapy for malaria. Trends in Parasitology. 2013 Oct;29(10):497-504. https://doi.org/10.1016/j.pt.2013.07.008

Author

Venkatesan, Meera ; Alifrangis, Michael ; Roper, Cally ; Plowe, Christopher V. / Monitoring antifolate resistance in intermittent preventive therapy for malaria. In: Trends in Parasitology. 2013 ; Vol. 29, No. 10. pp. 497-504.

Bibtex

@article{6a7da968597d42278cac7b5d5fb2fcc3,
title = "Monitoring antifolate resistance in intermittent preventive therapy for malaria",
abstract = "Mutations in the Plasmodium falciparum genes Pfdhfr and Pfdhps have rendered sulfadoxine-pyrimethamine (SP) ineffective for malaria treatment in most regions of the world. Yet, SP is efficacious as intermittent preventive therapy in pregnant women (IPTp) and infants (IPTi) and as seasonal malaria control in children (SMC). SP-IPTp is being widely implemented in sub-Saharan Africa. SP-IPTi is recommended where the prevalence of SP-resistant malaria parasites is low, whereas SMC is recommended for areas of intense seasonal malaria transmission. The continuing success of these interventions depends largely on the prevalence of Pfdhfr and Pfdhps resistance mutations in the target population. Here we review the relationship between resistance mutations and SP-IPT within target populations in the context of monitoring and informing implementation of this intervention.",
author = "Meera Venkatesan and Michael Alifrangis and Cally Roper and Plowe, {Christopher V}",
note = "Copyright {\textcopyright} 2013 Elsevier Ltd. All rights reserved.",
year = "2013",
month = oct,
doi = "10.1016/j.pt.2013.07.008",
language = "English",
volume = "29",
pages = "497--504",
journal = "Trends in Parasitology",
issn = "1471-4922",
publisher = "Elsevier Ltd. * Trends Journals",
number = "10",

}

RIS

TY - JOUR

T1 - Monitoring antifolate resistance in intermittent preventive therapy for malaria

AU - Venkatesan, Meera

AU - Alifrangis, Michael

AU - Roper, Cally

AU - Plowe, Christopher V

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2013/10

Y1 - 2013/10

N2 - Mutations in the Plasmodium falciparum genes Pfdhfr and Pfdhps have rendered sulfadoxine-pyrimethamine (SP) ineffective for malaria treatment in most regions of the world. Yet, SP is efficacious as intermittent preventive therapy in pregnant women (IPTp) and infants (IPTi) and as seasonal malaria control in children (SMC). SP-IPTp is being widely implemented in sub-Saharan Africa. SP-IPTi is recommended where the prevalence of SP-resistant malaria parasites is low, whereas SMC is recommended for areas of intense seasonal malaria transmission. The continuing success of these interventions depends largely on the prevalence of Pfdhfr and Pfdhps resistance mutations in the target population. Here we review the relationship between resistance mutations and SP-IPT within target populations in the context of monitoring and informing implementation of this intervention.

AB - Mutations in the Plasmodium falciparum genes Pfdhfr and Pfdhps have rendered sulfadoxine-pyrimethamine (SP) ineffective for malaria treatment in most regions of the world. Yet, SP is efficacious as intermittent preventive therapy in pregnant women (IPTp) and infants (IPTi) and as seasonal malaria control in children (SMC). SP-IPTp is being widely implemented in sub-Saharan Africa. SP-IPTi is recommended where the prevalence of SP-resistant malaria parasites is low, whereas SMC is recommended for areas of intense seasonal malaria transmission. The continuing success of these interventions depends largely on the prevalence of Pfdhfr and Pfdhps resistance mutations in the target population. Here we review the relationship between resistance mutations and SP-IPT within target populations in the context of monitoring and informing implementation of this intervention.

U2 - 10.1016/j.pt.2013.07.008

DO - 10.1016/j.pt.2013.07.008

M3 - Journal article

C2 - 23948432

VL - 29

SP - 497

EP - 504

JO - Trends in Parasitology

JF - Trends in Parasitology

SN - 1471-4922

IS - 10

ER -

ID: 61967353