Molecular assays for antimalarial drug resistance surveillance: A target product profile
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Molecular assays for antimalarial drug resistance surveillance : A target product profile. / Nsanzabana, Christian; Ariey, Frederic; Beck, Hans Peter; Ding, Xavier C.; Kamau, Edwin; Krishna, Sanjeev; Legrand, Eric; Lucchi, Naomi; Miotto, Olivo; Nag, Sidsel; Noedl, Harald; Roper, Cally; Rosenthal, Philip J.; Schallig, Henk D.F.H.; Taylor, Steve M.; Volkman, Sarah K.; Gonzalez, Iveth J.
In: PLOS ONE, Vol. 13, No. 9, e0204347, 2018.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Molecular assays for antimalarial drug resistance surveillance
T2 - A target product profile
AU - Nsanzabana, Christian
AU - Ariey, Frederic
AU - Beck, Hans Peter
AU - Ding, Xavier C.
AU - Kamau, Edwin
AU - Krishna, Sanjeev
AU - Legrand, Eric
AU - Lucchi, Naomi
AU - Miotto, Olivo
AU - Nag, Sidsel
AU - Noedl, Harald
AU - Roper, Cally
AU - Rosenthal, Philip J.
AU - Schallig, Henk D.F.H.
AU - Taylor, Steve M.
AU - Volkman, Sarah K.
AU - Gonzalez, Iveth J.
PY - 2018
Y1 - 2018
N2 - Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance following treatment with artemisinin derivatives has now spread in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination therapies are expected to be available in the near future. There is a need to strengthen surveillance systems for early detection and response to the antimalarial drug resistance threat. Current surveillance is mainly done through therapeutic efficacy studies; however these studies are complex and both time- and resource-intensive. For multiple common antimalarials, parasite drug resistance has been correlated with specific genetic mutations, and the molecular markers associated with antimalarial drug resistance offer a simple and powerful tool to monitor the emergence and spread of resistant parasites. Different techniques to analyse molecular markers associated with antimalarial drug resistance are available, each with advantages and disadvantages. However, procedures are not adequately harmonized to facilitate comparisons between sites. Here we describe the target product profiles for tests to analyse molecular markers associated with antimalarial drug resistance, discuss how use of current techniques can be standardised, and identify the requirements for an ideal product that would allow malaria endemic countries to provide useful spatial and temporal information on the spread of resistance.
AB - Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance following treatment with artemisinin derivatives has now spread in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination therapies are expected to be available in the near future. There is a need to strengthen surveillance systems for early detection and response to the antimalarial drug resistance threat. Current surveillance is mainly done through therapeutic efficacy studies; however these studies are complex and both time- and resource-intensive. For multiple common antimalarials, parasite drug resistance has been correlated with specific genetic mutations, and the molecular markers associated with antimalarial drug resistance offer a simple and powerful tool to monitor the emergence and spread of resistant parasites. Different techniques to analyse molecular markers associated with antimalarial drug resistance are available, each with advantages and disadvantages. However, procedures are not adequately harmonized to facilitate comparisons between sites. Here we describe the target product profiles for tests to analyse molecular markers associated with antimalarial drug resistance, discuss how use of current techniques can be standardised, and identify the requirements for an ideal product that would allow malaria endemic countries to provide useful spatial and temporal information on the spread of resistance.
U2 - 10.1371/journal.pone.0204347
DO - 10.1371/journal.pone.0204347
M3 - Journal article
C2 - 30235327
AN - SCOPUS:85053676487
VL - 13
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9
M1 - e0204347
ER -
ID: 208878479