Mechanisms involved in the evasion of the host defence by Pseudomonas aeruginosa

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Mechanisms involved in the evasion of the host defence by Pseudomonas aeruginosa. / Kharazmi, A.

In: Immunology Letters, Vol. 30, No. 2, 1991, p. 201-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kharazmi, A 1991, 'Mechanisms involved in the evasion of the host defence by Pseudomonas aeruginosa', Immunology Letters, vol. 30, no. 2, pp. 201-5.

APA

Kharazmi, A. (1991). Mechanisms involved in the evasion of the host defence by Pseudomonas aeruginosa. Immunology Letters, 30(2), 201-5.

Vancouver

Kharazmi A. Mechanisms involved in the evasion of the host defence by Pseudomonas aeruginosa. Immunology Letters. 1991;30(2):201-5.

Author

Kharazmi, A. / Mechanisms involved in the evasion of the host defence by Pseudomonas aeruginosa. In: Immunology Letters. 1991 ; Vol. 30, No. 2. pp. 201-5.

Bibtex

@article{f43a13b0207a11df8ed1000ea68e967b,
title = "Mechanisms involved in the evasion of the host defence by Pseudomonas aeruginosa",
abstract = "Pseudomonas aeruginosa, an extracellular opportunistic pathogen, utilizes two major mechanisms to evade the host defence system. One of these mechanisms is the production of a large number of extracellular products, such as proteases, toxins, and lipases. The two proteases, alkaline protease and elastase, inhibit the function of the cells of the immune system (phagocytes, NK cells, T cells), inactivate several cytokines (IL-1, IL-2, IFN-r, TNF), cleave immunoglobulins and inactivate complement. Inhibition of the local immune response by bacterial proteases provides an environment for the colonization and establishment of chronic infection. The other mechanism by which P. aeruginosa evades the host defence system is the biofilm mode of growth of the bacteria in chronic infections. The biofilm-grown bacteria induce a low phagocyte response, and provide a barrier for the bacteria against antibodies, complement, and the cells of the immune system. Protection from the host defence system combined with increased antibiotic resistance of the bacteria in the biofilm are the major reasons for the persistence of P. aeruginosa in chronic infections.",
author = "A Kharazmi",
note = "Keywords: Animals; Humans; Pancreatic Elastase; Pseudomonas Infections; Pseudomonas aeruginosa; Serine Endopeptidases",
year = "1991",
language = "English",
volume = "30",
pages = "201--5",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Mechanisms involved in the evasion of the host defence by Pseudomonas aeruginosa

AU - Kharazmi, A

N1 - Keywords: Animals; Humans; Pancreatic Elastase; Pseudomonas Infections; Pseudomonas aeruginosa; Serine Endopeptidases

PY - 1991

Y1 - 1991

N2 - Pseudomonas aeruginosa, an extracellular opportunistic pathogen, utilizes two major mechanisms to evade the host defence system. One of these mechanisms is the production of a large number of extracellular products, such as proteases, toxins, and lipases. The two proteases, alkaline protease and elastase, inhibit the function of the cells of the immune system (phagocytes, NK cells, T cells), inactivate several cytokines (IL-1, IL-2, IFN-r, TNF), cleave immunoglobulins and inactivate complement. Inhibition of the local immune response by bacterial proteases provides an environment for the colonization and establishment of chronic infection. The other mechanism by which P. aeruginosa evades the host defence system is the biofilm mode of growth of the bacteria in chronic infections. The biofilm-grown bacteria induce a low phagocyte response, and provide a barrier for the bacteria against antibodies, complement, and the cells of the immune system. Protection from the host defence system combined with increased antibiotic resistance of the bacteria in the biofilm are the major reasons for the persistence of P. aeruginosa in chronic infections.

AB - Pseudomonas aeruginosa, an extracellular opportunistic pathogen, utilizes two major mechanisms to evade the host defence system. One of these mechanisms is the production of a large number of extracellular products, such as proteases, toxins, and lipases. The two proteases, alkaline protease and elastase, inhibit the function of the cells of the immune system (phagocytes, NK cells, T cells), inactivate several cytokines (IL-1, IL-2, IFN-r, TNF), cleave immunoglobulins and inactivate complement. Inhibition of the local immune response by bacterial proteases provides an environment for the colonization and establishment of chronic infection. The other mechanism by which P. aeruginosa evades the host defence system is the biofilm mode of growth of the bacteria in chronic infections. The biofilm-grown bacteria induce a low phagocyte response, and provide a barrier for the bacteria against antibodies, complement, and the cells of the immune system. Protection from the host defence system combined with increased antibiotic resistance of the bacteria in the biofilm are the major reasons for the persistence of P. aeruginosa in chronic infections.

M3 - Journal article

C2 - 1757106

VL - 30

SP - 201

EP - 205

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

IS - 2

ER -

ID: 18177835