Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro

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Standard

Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro. / Jensen, Sophie; Omarsdottir, Sesselja; Bwalya, Angela Gono; Nielsen, Morten Agertoug; Tasdemir, Deniz; Olafsdottir, Elin Soffia.

In: Phytomedicine, Vol. 19, No. 13, 2012, p. 1191-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jensen, S, Omarsdottir, S, Bwalya, AG, Nielsen, MA, Tasdemir, D & Olafsdottir, ES 2012, 'Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro', Phytomedicine, vol. 19, no. 13, pp. 1191-5. https://doi.org/10.1016/j.phymed.2012.07.011

APA

Jensen, S., Omarsdottir, S., Bwalya, A. G., Nielsen, M. A., Tasdemir, D., & Olafsdottir, E. S. (2012). Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro. Phytomedicine, 19(13), 1191-5. https://doi.org/10.1016/j.phymed.2012.07.011

Vancouver

Jensen S, Omarsdottir S, Bwalya AG, Nielsen MA, Tasdemir D, Olafsdottir ES. Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro. Phytomedicine. 2012;19(13):1191-5. https://doi.org/10.1016/j.phymed.2012.07.011

Author

Jensen, Sophie ; Omarsdottir, Sesselja ; Bwalya, Angela Gono ; Nielsen, Morten Agertoug ; Tasdemir, Deniz ; Olafsdottir, Elin Soffia. / Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro. In: Phytomedicine. 2012 ; Vol. 19, No. 13. pp. 1191-5.

Bibtex

@article{a065842e926b4f329782010f173ef6a7,
title = "Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro",
abstract = "In vitro anti-plasmodial activity-guided fractionation of a diethyl ether extract of the liverwort species Marchantia polymorpha, collected in Iceland, led to isolation of the bisbibenzyl ether, marchantin A. The structure of marchantin A (1) was confirmed by NMR and HREIMS. Marchantin A inhibited proliferation of the Plasmodium falciparum strains, NF54 (IC(50)=3.41µM) and K1 (IC(50)=2.02µM) and showed activity against other protozoan species Trypanosoma brucei rhodesiense, T. cruzi and Leishmania donovani with IC(50) values 2.09, 14.90 and 1.59µM, respectively. Marchantin A was tested against three recombinant enzymes (PfFabI, PfFabG and PfFabZ) of the PfFAS-II pathway of P. falciparum for malaria prophylactic potential and showed moderate inhibitory activity against PfFabZ (IC(50)=18.18µM). In addition the cytotoxic effect of marchantin A was evaluated. This is the first report describing the inhibitory effects of the liverwort metabolite marchantin A against these parasites in vitro.",
author = "Sophie Jensen and Sesselja Omarsdottir and Bwalya, {Angela Gono} and Nielsen, {Morten Agertoug} and Deniz Tasdemir and Olafsdottir, {Elin Soffia}",
note = "Copyright {\textcopyright} 2012 Elsevier GmbH. All rights reserved.",
year = "2012",
doi = "10.1016/j.phymed.2012.07.011",
language = "English",
volume = "19",
pages = "1191--5",
journal = "Phytomedicine",
issn = "0944-7113",
publisher = "Elsevier GmbH - Urban und Fischer",
number = "13",

}

RIS

TY - JOUR

T1 - Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro

AU - Jensen, Sophie

AU - Omarsdottir, Sesselja

AU - Bwalya, Angela Gono

AU - Nielsen, Morten Agertoug

AU - Tasdemir, Deniz

AU - Olafsdottir, Elin Soffia

N1 - Copyright © 2012 Elsevier GmbH. All rights reserved.

PY - 2012

Y1 - 2012

N2 - In vitro anti-plasmodial activity-guided fractionation of a diethyl ether extract of the liverwort species Marchantia polymorpha, collected in Iceland, led to isolation of the bisbibenzyl ether, marchantin A. The structure of marchantin A (1) was confirmed by NMR and HREIMS. Marchantin A inhibited proliferation of the Plasmodium falciparum strains, NF54 (IC(50)=3.41µM) and K1 (IC(50)=2.02µM) and showed activity against other protozoan species Trypanosoma brucei rhodesiense, T. cruzi and Leishmania donovani with IC(50) values 2.09, 14.90 and 1.59µM, respectively. Marchantin A was tested against three recombinant enzymes (PfFabI, PfFabG and PfFabZ) of the PfFAS-II pathway of P. falciparum for malaria prophylactic potential and showed moderate inhibitory activity against PfFabZ (IC(50)=18.18µM). In addition the cytotoxic effect of marchantin A was evaluated. This is the first report describing the inhibitory effects of the liverwort metabolite marchantin A against these parasites in vitro.

AB - In vitro anti-plasmodial activity-guided fractionation of a diethyl ether extract of the liverwort species Marchantia polymorpha, collected in Iceland, led to isolation of the bisbibenzyl ether, marchantin A. The structure of marchantin A (1) was confirmed by NMR and HREIMS. Marchantin A inhibited proliferation of the Plasmodium falciparum strains, NF54 (IC(50)=3.41µM) and K1 (IC(50)=2.02µM) and showed activity against other protozoan species Trypanosoma brucei rhodesiense, T. cruzi and Leishmania donovani with IC(50) values 2.09, 14.90 and 1.59µM, respectively. Marchantin A was tested against three recombinant enzymes (PfFabI, PfFabG and PfFabZ) of the PfFAS-II pathway of P. falciparum for malaria prophylactic potential and showed moderate inhibitory activity against PfFabZ (IC(50)=18.18µM). In addition the cytotoxic effect of marchantin A was evaluated. This is the first report describing the inhibitory effects of the liverwort metabolite marchantin A against these parasites in vitro.

U2 - 10.1016/j.phymed.2012.07.011

DO - 10.1016/j.phymed.2012.07.011

M3 - Journal article

C2 - 22951393

VL - 19

SP - 1191

EP - 1195

JO - Phytomedicine

JF - Phytomedicine

SN - 0944-7113

IS - 13

ER -

ID: 40849610