Malaria in pregnancy: pathogenesis and immunity
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Malaria in pregnancy: pathogenesis and immunity. / Rogerson, Stephen J; Hviid, Lars; Duffy, Patrick E; Leke, Rose F G; Taylor, Diane W.
In: Lancet Infectious Diseases, Vol. 7, No. 2, 2007, p. 105-17.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Malaria in pregnancy: pathogenesis and immunity
AU - Rogerson, Stephen J
AU - Hviid, Lars
AU - Duffy, Patrick E
AU - Leke, Rose F G
AU - Taylor, Diane W
N1 - Keywords: Animals; Antibodies, Protozoan; Erythrocytes; Female; Humans; Immunity, Cellular; Malaria, Falciparum; Placenta; Placenta Diseases; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Parasitic
PY - 2007
Y1 - 2007
N2 - Understanding of the biological basis for susceptibility to malaria in pregnancy was recently advanced by the discovery that erythrocytes infected with Plasmodium falciparum accumulate in the placenta through adhesion to molecules such as chondroitin sulphate A. Antibody recognition of placental infected erythrocytes is dependent on sex and gravidity, and could protect from malaria complications. Moreover, a conserved parasite gene-var2csa-has been associated with placental malaria, suggesting that its product might be an appropriate vaccine candidate. By contrast, our understanding of placental immunopathology and how this contributes to anaemia and low birthweight remains restricted, although inflammatory cytokines produced by T cells, macrophages, and other cells are clearly important. Studies that unravel the role of host response to malaria in pathology and protection in the placenta, and that dissect the relation between timing of infection and outcome, could allow improved targeting of preventive treatments and development of a vaccine for use in pregnant women.
AB - Understanding of the biological basis for susceptibility to malaria in pregnancy was recently advanced by the discovery that erythrocytes infected with Plasmodium falciparum accumulate in the placenta through adhesion to molecules such as chondroitin sulphate A. Antibody recognition of placental infected erythrocytes is dependent on sex and gravidity, and could protect from malaria complications. Moreover, a conserved parasite gene-var2csa-has been associated with placental malaria, suggesting that its product might be an appropriate vaccine candidate. By contrast, our understanding of placental immunopathology and how this contributes to anaemia and low birthweight remains restricted, although inflammatory cytokines produced by T cells, macrophages, and other cells are clearly important. Studies that unravel the role of host response to malaria in pathology and protection in the placenta, and that dissect the relation between timing of infection and outcome, could allow improved targeting of preventive treatments and development of a vaccine for use in pregnant women.
U2 - 10.1016/S1473-3099(07)70022-1
DO - 10.1016/S1473-3099(07)70022-1
M3 - Journal article
C2 - 17251081
VL - 7
SP - 105
EP - 117
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
SN - 1473-3099
IS - 2
ER -
ID: 6746520