Lessons learned in conducting mass drug administration for Schistosomiasis control and measuring coverage in an operational research setting
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Lessons learned in conducting mass drug administration for Schistosomiasis control and measuring coverage in an operational research setting. / Binder, Sue; Campbell, Carl H; Castleman, Jennifer D; Kittur, Nupur; Kinung'hi, Safari M; Olsen, Annette; Magnussen, Pascal; Karanja, Diana M S; Mwinzi, Pauline N M; Montgomery, Susan P; Secor, William Evan; Phillips, Anna E; Dhanani, Neerav; Gazzinelli-Guimaraes, Pedro H; Clements, Michelle N; N'Goran, Eliézer K; Meite, Aboulaye; Utzinger, Jürg; Hamidou, Amina A; Garba, Amadou; Fleming, Fiona M; Whalen, Christopher C; King, Charles H; Colley, Daniel G.
In: American Journal of Tropical Medicine and Hygiene, Vol. 103, No. 1_Suppl, 2020, p. 105-113.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Lessons learned in conducting mass drug administration for Schistosomiasis control and measuring coverage in an operational research setting
AU - Binder, Sue
AU - Campbell, Carl H
AU - Castleman, Jennifer D
AU - Kittur, Nupur
AU - Kinung'hi, Safari M
AU - Olsen, Annette
AU - Magnussen, Pascal
AU - Karanja, Diana M S
AU - Mwinzi, Pauline N M
AU - Montgomery, Susan P
AU - Secor, William Evan
AU - Phillips, Anna E
AU - Dhanani, Neerav
AU - Gazzinelli-Guimaraes, Pedro H
AU - Clements, Michelle N
AU - N'Goran, Eliézer K
AU - Meite, Aboulaye
AU - Utzinger, Jürg
AU - Hamidou, Amina A
AU - Garba, Amadou
AU - Fleming, Fiona M
AU - Whalen, Christopher C
AU - King, Charles H
AU - Colley, Daniel G
PY - 2020
Y1 - 2020
N2 - The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was created to conduct research that could inform programmatic decision-making related to schistosomiasis. SCORE included several large cluster randomized field studies involving mass drug administration (MDA) with praziquantel. The largest of these were studies of gaining or sustaining control of schistosomiasis, which were conducted in five African countries. To enhance relevance for routine practice, the MDA in these studies was coordinated by or closely aligned with national neglected tropical disease (NTD) control programs. The study protocol set minimum targets of at least 90% for coverage among children enrolled in schools and 75% for all school-age children. Over the 4 years of intervention, an estimated 3.5 million treatments were administered to study communities. By year 4, the median village coverage was at or above targets in all studies except that in Mozambique. However, there was often a wide variation behind these summary statistics, and all studies had several villages with very low or high coverage. In studies where coverage was estimated by comparing the number of people treated with the number eligible for treatment, denominator estimation was often problematic. The SCORE experiences in conducting these studies provide lessons for future efforts that attempt to implement strong research designs in real-world contexts. They also have potential applicability to country MDA campaigns against schistosomiasis and other NTDs, most of which are conducted with less logistical and financial support than was available for the SCORE study efforts.
AB - The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was created to conduct research that could inform programmatic decision-making related to schistosomiasis. SCORE included several large cluster randomized field studies involving mass drug administration (MDA) with praziquantel. The largest of these were studies of gaining or sustaining control of schistosomiasis, which were conducted in five African countries. To enhance relevance for routine practice, the MDA in these studies was coordinated by or closely aligned with national neglected tropical disease (NTD) control programs. The study protocol set minimum targets of at least 90% for coverage among children enrolled in schools and 75% for all school-age children. Over the 4 years of intervention, an estimated 3.5 million treatments were administered to study communities. By year 4, the median village coverage was at or above targets in all studies except that in Mozambique. However, there was often a wide variation behind these summary statistics, and all studies had several villages with very low or high coverage. In studies where coverage was estimated by comparing the number of people treated with the number eligible for treatment, denominator estimation was often problematic. The SCORE experiences in conducting these studies provide lessons for future efforts that attempt to implement strong research designs in real-world contexts. They also have potential applicability to country MDA campaigns against schistosomiasis and other NTDs, most of which are conducted with less logistical and financial support than was available for the SCORE study efforts.
U2 - 10.4269/ajtmh.19-0789
DO - 10.4269/ajtmh.19-0789
M3 - Journal article
C2 - 32400352
VL - 103
SP - 105
EP - 113
JO - Journal. National Malaria Society
JF - Journal. National Malaria Society
SN - 0002-9637
IS - 1_Suppl
ER -
ID: 245194450