Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso?

Research output: Contribution to journal › Journal article › Research › peer-review

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Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso? / Cherif, Mariama K; Sanou, Guillaume S; Bougouma, Edith C; Diarra, Amidou; Ouédraogo, Alphonse; Dolo, Amagana; Troye-Blomberg, Marita; Cavanagh, David R; Theisen, Michael; Modiano, David; Sirima, Sodiomon B; Nebié, Issa.

In: Acta Tropica, Vol. 142, 02.2015, p. 41-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cherif, MK, Sanou, GS, Bougouma, EC, Diarra, A, Ouédraogo, A, Dolo, A, Troye-Blomberg, M, Cavanagh, DR, Theisen, M, Modiano, D, Sirima, SB & Nebié, I 2015, 'Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso?', Acta Tropica, vol. 142, pp. 41-6. https://doi.org/10.1016/j.actatropica.2014.09.019

APA

Cherif, M. K., Sanou, G. S., Bougouma, E. C., Diarra, A., Ouédraogo, A., Dolo, A., Troye-Blomberg, M., Cavanagh, D. R., Theisen, M., Modiano, D., Sirima, S. B., & Nebié, I. (2015). Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso? Acta Tropica, 142, 41-6. https://doi.org/10.1016/j.actatropica.2014.09.019

Vancouver

Cherif MK, Sanou GS, Bougouma EC, Diarra A, Ouédraogo A, Dolo A et al. Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso? Acta Tropica. 2015 Feb;142:41-6. https://doi.org/10.1016/j.actatropica.2014.09.019

Author

Cherif, Mariama K ; Sanou, Guillaume S ; Bougouma, Edith C ; Diarra, Amidou ; Ouédraogo, Alphonse ; Dolo, Amagana ; Troye-Blomberg, Marita ; Cavanagh, David R ; Theisen, Michael ; Modiano, David ; Sirima, Sodiomon B ; Nebié, Issa. / Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso?. In: Acta Tropica. 2015 ; Vol. 142. pp. 41-6.

Bibtex

@article{3ab5619bfaf94f6f8ba58253790a3e96,
title = "Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso?",
abstract = "In the present study, the influences of FcγRIIA polymorphism on susceptibility to malaria and antibody responses to Plasmodium falciparum antigens were analyzed in children. We recruited 96 healthy children between 3 and 10 years at the beginning of the high transmission season and we followed up for 5 months through the high transmission season to assess the parasitological, immunological and genetic endpoints in relation to clinical malaria status. There was a similar distribution of homozygous and heterozygous individuals carrying the FcγRIIA-131R/R and FcγRIIA-131R/H allele, whereas the number of FcγRIIA-131H/H homozygous individuals was lower. P. falciparum infection frequency was not associated with the FcγRIIa-131R/H polymorphism. Only IgG antibody responses to GLURP R0 showed a significant association between antibody levels and FcγRIIA polymorphism (p=0.02). IgG levels to MSP2a were significantly higher in children who did not experience any clinical malaria episode compared to those who experienced at least one malaria episode (p=0.019). Cytophilic and non-cytophylic IgG subclass levels were higher in children without malaria than those who experienced at least one malaria episode. This difference was statistically significant for IgG1 to MSP3 (p=0.003) and to MSP2a (p=0.006); IgG3 to MSP2a (p=0.007) and to GLURP R0 (p=0.044); IgG2 to MSP2b (p=0.007) and IgG4 to MSP3 (p=0.051) and to MSP2a (p=0.049). In this study, homozygous carriers of the FcγRIIA-131R/R allele had higher malaria-specific antibody levels compare to the heterozygous carriers FcγRIIA-131R/H alleles and to homozygous carriers of FcγRIIA-131H/H alleles. The pre-existing antibodies responses were related to a reduced subsequent risk of clinical malaria.",
author = "Cherif, {Mariama K} and Sanou, {Guillaume S} and Bougouma, {Edith C} and Amidou Diarra and Alphonse Ou{\'e}draogo and Amagana Dolo and Marita Troye-Blomberg and Cavanagh, {David R} and Michael Theisen and David Modiano and Sirima, {Sodiomon B} and Issa Nebi{\'e}",
note = "Copyright {\textcopyright} 2014 Elsevier B.V. All rights reserved.",
year = "2015",
month = feb,
doi = "10.1016/j.actatropica.2014.09.019",
language = "English",
volume = "142",
pages = "41--6",
journal = "Acta Tropica",
issn = "0001-706X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso?

AU - Cherif, Mariama K

AU - Sanou, Guillaume S

AU - Bougouma, Edith C

AU - Diarra, Amidou

AU - Ouédraogo, Alphonse

AU - Dolo, Amagana

AU - Troye-Blomberg, Marita

AU - Cavanagh, David R

AU - Theisen, Michael

AU - Modiano, David

AU - Sirima, Sodiomon B

AU - Nebié, Issa

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2015/2

Y1 - 2015/2

N2 - In the present study, the influences of FcγRIIA polymorphism on susceptibility to malaria and antibody responses to Plasmodium falciparum antigens were analyzed in children. We recruited 96 healthy children between 3 and 10 years at the beginning of the high transmission season and we followed up for 5 months through the high transmission season to assess the parasitological, immunological and genetic endpoints in relation to clinical malaria status. There was a similar distribution of homozygous and heterozygous individuals carrying the FcγRIIA-131R/R and FcγRIIA-131R/H allele, whereas the number of FcγRIIA-131H/H homozygous individuals was lower. P. falciparum infection frequency was not associated with the FcγRIIa-131R/H polymorphism. Only IgG antibody responses to GLURP R0 showed a significant association between antibody levels and FcγRIIA polymorphism (p=0.02). IgG levels to MSP2a were significantly higher in children who did not experience any clinical malaria episode compared to those who experienced at least one malaria episode (p=0.019). Cytophilic and non-cytophylic IgG subclass levels were higher in children without malaria than those who experienced at least one malaria episode. This difference was statistically significant for IgG1 to MSP3 (p=0.003) and to MSP2a (p=0.006); IgG3 to MSP2a (p=0.007) and to GLURP R0 (p=0.044); IgG2 to MSP2b (p=0.007) and IgG4 to MSP3 (p=0.051) and to MSP2a (p=0.049). In this study, homozygous carriers of the FcγRIIA-131R/R allele had higher malaria-specific antibody levels compare to the heterozygous carriers FcγRIIA-131R/H alleles and to homozygous carriers of FcγRIIA-131H/H alleles. The pre-existing antibodies responses were related to a reduced subsequent risk of clinical malaria.

AB - In the present study, the influences of FcγRIIA polymorphism on susceptibility to malaria and antibody responses to Plasmodium falciparum antigens were analyzed in children. We recruited 96 healthy children between 3 and 10 years at the beginning of the high transmission season and we followed up for 5 months through the high transmission season to assess the parasitological, immunological and genetic endpoints in relation to clinical malaria status. There was a similar distribution of homozygous and heterozygous individuals carrying the FcγRIIA-131R/R and FcγRIIA-131R/H allele, whereas the number of FcγRIIA-131H/H homozygous individuals was lower. P. falciparum infection frequency was not associated with the FcγRIIa-131R/H polymorphism. Only IgG antibody responses to GLURP R0 showed a significant association between antibody levels and FcγRIIA polymorphism (p=0.02). IgG levels to MSP2a were significantly higher in children who did not experience any clinical malaria episode compared to those who experienced at least one malaria episode (p=0.019). Cytophilic and non-cytophylic IgG subclass levels were higher in children without malaria than those who experienced at least one malaria episode. This difference was statistically significant for IgG1 to MSP3 (p=0.003) and to MSP2a (p=0.006); IgG3 to MSP2a (p=0.007) and to GLURP R0 (p=0.044); IgG2 to MSP2b (p=0.007) and IgG4 to MSP3 (p=0.051) and to MSP2a (p=0.049). In this study, homozygous carriers of the FcγRIIA-131R/R allele had higher malaria-specific antibody levels compare to the heterozygous carriers FcγRIIA-131R/H alleles and to homozygous carriers of FcγRIIA-131H/H alleles. The pre-existing antibodies responses were related to a reduced subsequent risk of clinical malaria.

U2 - 10.1016/j.actatropica.2014.09.019

DO - 10.1016/j.actatropica.2014.09.019

M3 - Journal article

C2 - 25447268

VL - 142

SP - 41

EP - 46

JO - Acta Tropica

JF - Acta Tropica

SN - 0001-706X

ER -

ID: 130282906