Investigation of Hydrogen Sulfide Gas as a Treatment against P. falciparum, Murine Cerebral Malaria, and the Importance of Thiolation State in the Development of Cerebral Malaria

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Standard

Investigation of Hydrogen Sulfide Gas as a Treatment against P. falciparum, Murine Cerebral Malaria, and the Importance of Thiolation State in the Development of Cerebral Malaria. / Dellavalle, Brian; Staalsoe, Trine; Kurtzhals, Jørgen Anders; Hempel, Casper.

In: P L o S One, Vol. 8, No. 3, 2013, p. e59271.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dellavalle, B, Staalsoe, T, Kurtzhals, JA & Hempel, C 2013, 'Investigation of Hydrogen Sulfide Gas as a Treatment against P. falciparum, Murine Cerebral Malaria, and the Importance of Thiolation State in the Development of Cerebral Malaria', P L o S One, vol. 8, no. 3, pp. e59271. https://doi.org/10.1371/journal.pone.0059271

APA

Dellavalle, B., Staalsoe, T., Kurtzhals, J. A., & Hempel, C. (2013). Investigation of Hydrogen Sulfide Gas as a Treatment against P. falciparum, Murine Cerebral Malaria, and the Importance of Thiolation State in the Development of Cerebral Malaria. P L o S One, 8(3), e59271. https://doi.org/10.1371/journal.pone.0059271

Vancouver

Dellavalle B, Staalsoe T, Kurtzhals JA, Hempel C. Investigation of Hydrogen Sulfide Gas as a Treatment against P. falciparum, Murine Cerebral Malaria, and the Importance of Thiolation State in the Development of Cerebral Malaria. P L o S One. 2013;8(3):e59271. https://doi.org/10.1371/journal.pone.0059271

Author

Dellavalle, Brian ; Staalsoe, Trine ; Kurtzhals, Jørgen Anders ; Hempel, Casper. / Investigation of Hydrogen Sulfide Gas as a Treatment against P. falciparum, Murine Cerebral Malaria, and the Importance of Thiolation State in the Development of Cerebral Malaria. In: P L o S One. 2013 ; Vol. 8, No. 3. pp. e59271.

Bibtex

@article{825cfbfbd38849c4bb829256fe1de352,
title = "Investigation of Hydrogen Sulfide Gas as a Treatment against P. falciparum, Murine Cerebral Malaria, and the Importance of Thiolation State in the Development of Cerebral Malaria",
abstract = "Cerebral malaria (CM) is a potentially fatal cerebrovascular disease of complex pathogenesis caused by Plasmodium falciparum. Hydrogen sulfide (HS) is a physiological gas, similar to nitric oxide and carbon monoxide, involved in cellular metabolism, vascular tension, inflammation, and cell death. HS treatment has shown promising results as a therapy for cardio- and neuro- pathology. This study investigates the effects of fast (NaHS) and slow (GYY4137) HS-releasing drugs on the growth and metabolism of P. falciparum and the development of P. berghei ANKA CM. Moreover, we investigate the role of free plasma thiols and cell surface thiols in the pathogenesis of CM.",
author = "Brian Dellavalle and Trine Staalsoe and Kurtzhals, {J{\o}rgen Anders} and Casper Hempel",
year = "2013",
doi = "10.1371/journal.pone.0059271",
language = "English",
volume = "8",
pages = "e59271",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Investigation of Hydrogen Sulfide Gas as a Treatment against P. falciparum, Murine Cerebral Malaria, and the Importance of Thiolation State in the Development of Cerebral Malaria

AU - Dellavalle, Brian

AU - Staalsoe, Trine

AU - Kurtzhals, Jørgen Anders

AU - Hempel, Casper

PY - 2013

Y1 - 2013

N2 - Cerebral malaria (CM) is a potentially fatal cerebrovascular disease of complex pathogenesis caused by Plasmodium falciparum. Hydrogen sulfide (HS) is a physiological gas, similar to nitric oxide and carbon monoxide, involved in cellular metabolism, vascular tension, inflammation, and cell death. HS treatment has shown promising results as a therapy for cardio- and neuro- pathology. This study investigates the effects of fast (NaHS) and slow (GYY4137) HS-releasing drugs on the growth and metabolism of P. falciparum and the development of P. berghei ANKA CM. Moreover, we investigate the role of free plasma thiols and cell surface thiols in the pathogenesis of CM.

AB - Cerebral malaria (CM) is a potentially fatal cerebrovascular disease of complex pathogenesis caused by Plasmodium falciparum. Hydrogen sulfide (HS) is a physiological gas, similar to nitric oxide and carbon monoxide, involved in cellular metabolism, vascular tension, inflammation, and cell death. HS treatment has shown promising results as a therapy for cardio- and neuro- pathology. This study investigates the effects of fast (NaHS) and slow (GYY4137) HS-releasing drugs on the growth and metabolism of P. falciparum and the development of P. berghei ANKA CM. Moreover, we investigate the role of free plasma thiols and cell surface thiols in the pathogenesis of CM.

U2 - 10.1371/journal.pone.0059271

DO - 10.1371/journal.pone.0059271

M3 - Journal article

C2 - 23555646

VL - 8

SP - e59271

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 3

ER -

ID: 45049197