Inhibition of human monocyte chemotaxis and chemiluminescence by Pseudomonas aeruginosa elastase

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Inhibition of human monocyte chemotaxis and chemiluminescence by Pseudomonas aeruginosa elastase. / Kharazmi, A; Nielsen, H.

In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 99, No. 1, 1991, p. 93-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kharazmi, A & Nielsen, H 1991, 'Inhibition of human monocyte chemotaxis and chemiluminescence by Pseudomonas aeruginosa elastase', Acta Pathologica Microbiologica et Immunologica Scandinavica, vol. 99, no. 1, pp. 93-5.

APA

Kharazmi, A., & Nielsen, H. (1991). Inhibition of human monocyte chemotaxis and chemiluminescence by Pseudomonas aeruginosa elastase. Acta Pathologica Microbiologica et Immunologica Scandinavica, 99(1), 93-5.

Vancouver

Kharazmi A, Nielsen H. Inhibition of human monocyte chemotaxis and chemiluminescence by Pseudomonas aeruginosa elastase. Acta Pathologica Microbiologica et Immunologica Scandinavica. 1991;99(1):93-5.

Author

Kharazmi, A ; Nielsen, H. / Inhibition of human monocyte chemotaxis and chemiluminescence by Pseudomonas aeruginosa elastase. In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 1991 ; Vol. 99, No. 1. pp. 93-5.

Bibtex

@article{2dda6d40207b11df8ed1000ea68e967b,
title = "Inhibition of human monocyte chemotaxis and chemiluminescence by Pseudomonas aeruginosa elastase",
abstract = "The in vitro effect of Pseudomonas aeruginosa elastase on human monocyte function was examined. Mononuclear cells isolated from the peripheral blood of healthy individuals were incubated with various concentrations of elastase, and the chemotactic activity and chemiluminescence response of these cells were measured after washing the cells free of the enzyme. Elastase at concentrations of 0.1 micrograms/ml and higher inhibited the chemotactic activity of monocytes towards F-Met-Leu-Phe and zymosan-activated serum. The inhibition of chemiluminescence response was observed at as low as 0.125 micrograms/ml elastase. Monocytes/macrophages are known to be involved in the inflammation observed in the lungs of patients infected by P. aeruginosa. The inhibition of monocyte function by elastase may serve as an escape mechanism for this bacterium from these cells.",
author = "A Kharazmi and H Nielsen",
note = "Keywords: Bacterial Proteins; Chemotaxis, Leukocyte; Humans; Luminescent Measurements; Metalloendopeptidases; Monocytes; Pseudomonas aeruginosa",
year = "1991",
language = "English",
volume = "99",
pages = "93--5",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "1",

}

RIS

TY - JOUR

T1 - Inhibition of human monocyte chemotaxis and chemiluminescence by Pseudomonas aeruginosa elastase

AU - Kharazmi, A

AU - Nielsen, H

N1 - Keywords: Bacterial Proteins; Chemotaxis, Leukocyte; Humans; Luminescent Measurements; Metalloendopeptidases; Monocytes; Pseudomonas aeruginosa

PY - 1991

Y1 - 1991

N2 - The in vitro effect of Pseudomonas aeruginosa elastase on human monocyte function was examined. Mononuclear cells isolated from the peripheral blood of healthy individuals were incubated with various concentrations of elastase, and the chemotactic activity and chemiluminescence response of these cells were measured after washing the cells free of the enzyme. Elastase at concentrations of 0.1 micrograms/ml and higher inhibited the chemotactic activity of monocytes towards F-Met-Leu-Phe and zymosan-activated serum. The inhibition of chemiluminescence response was observed at as low as 0.125 micrograms/ml elastase. Monocytes/macrophages are known to be involved in the inflammation observed in the lungs of patients infected by P. aeruginosa. The inhibition of monocyte function by elastase may serve as an escape mechanism for this bacterium from these cells.

AB - The in vitro effect of Pseudomonas aeruginosa elastase on human monocyte function was examined. Mononuclear cells isolated from the peripheral blood of healthy individuals were incubated with various concentrations of elastase, and the chemotactic activity and chemiluminescence response of these cells were measured after washing the cells free of the enzyme. Elastase at concentrations of 0.1 micrograms/ml and higher inhibited the chemotactic activity of monocytes towards F-Met-Leu-Phe and zymosan-activated serum. The inhibition of chemiluminescence response was observed at as low as 0.125 micrograms/ml elastase. Monocytes/macrophages are known to be involved in the inflammation observed in the lungs of patients infected by P. aeruginosa. The inhibition of monocyte function by elastase may serve as an escape mechanism for this bacterium from these cells.

M3 - Journal article

C2 - 1899578

VL - 99

SP - 93

EP - 95

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 1

ER -

ID: 18177851