Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia

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Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia. / Alifrangis, Michael; Nag, Sidsel; Schousboe, Mette L; Ishengoma, Deus; Lusingu, John; Pota, Hirva; Kavishe, Reginald A; Pearce, Richard; Ord, Rosalynn; Lynch, Caroline; Dejene, Seyoum; Cox, Jonathan; Rwakimari, John; Minja, Daniel T R; Lemnge, Martha M; Roper, Cally.

In: Emerging Infectious Diseases (Print Edition), Vol. 20, No. 8, 08.2014, p. 1280-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Alifrangis, M, Nag, S, Schousboe, ML, Ishengoma, D, Lusingu, J, Pota, H, Kavishe, RA, Pearce, R, Ord, R, Lynch, C, Dejene, S, Cox, J, Rwakimari, J, Minja, DTR, Lemnge, MM & Roper, C 2014, 'Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia', Emerging Infectious Diseases (Print Edition), vol. 20, no. 8, pp. 1280-6. https://doi.org/10.3201/eid2008.131897

APA

Alifrangis, M., Nag, S., Schousboe, M. L., Ishengoma, D., Lusingu, J., Pota, H., Kavishe, R. A., Pearce, R., Ord, R., Lynch, C., Dejene, S., Cox, J., Rwakimari, J., Minja, D. T. R., Lemnge, M. M., & Roper, C. (2014). Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia. Emerging Infectious Diseases (Print Edition), 20(8), 1280-6. https://doi.org/10.3201/eid2008.131897

Vancouver

Alifrangis M, Nag S, Schousboe ML, Ishengoma D, Lusingu J, Pota H et al. Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia. Emerging Infectious Diseases (Print Edition). 2014 Aug;20(8):1280-6. https://doi.org/10.3201/eid2008.131897

Author

Alifrangis, Michael ; Nag, Sidsel ; Schousboe, Mette L ; Ishengoma, Deus ; Lusingu, John ; Pota, Hirva ; Kavishe, Reginald A ; Pearce, Richard ; Ord, Rosalynn ; Lynch, Caroline ; Dejene, Seyoum ; Cox, Jonathan ; Rwakimari, John ; Minja, Daniel T R ; Lemnge, Martha M ; Roper, Cally. / Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia. In: Emerging Infectious Diseases (Print Edition). 2014 ; Vol. 20, No. 8. pp. 1280-6.

Bibtex

@article{30537c4b0e9f4a8d8e59cfbc01792d48,
title = "Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia",
abstract = "Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine-pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps and the triple-mutant Pfdhfr. Using samples collected during 2004-2008, we investigated the evolutionary origin of the A581G mutation by characterizing microsatellite diversity flanking Pfdhps triple-mutant (437G+540E+581G) alleles from 3 locations in eastern Africa and comparing it with double-mutant (437G+540E) alleles from the same area. In Ethiopia, both alleles derived from 1 lineage that was distinct from those in Uganda and Tanzania. Uganda and Tanzania triple mutants derived from the previously characterized southeastern Africa double-mutant lineage. The A581G mutation has occurred multiple times on local Pfdhps double-mutant backgrounds; however, a novel microsatellite allele incorporated into the Tanzania lineage since 2004 illustrates the local expansion of emergent triple-mutant lineages.",
author = "Michael Alifrangis and Sidsel Nag and Schousboe, {Mette L} and Deus Ishengoma and John Lusingu and Hirva Pota and Kavishe, {Reginald A} and Richard Pearce and Rosalynn Ord and Caroline Lynch and Seyoum Dejene and Jonathan Cox and John Rwakimari and Minja, {Daniel T R} and Lemnge, {Martha M} and Cally Roper",
year = "2014",
month = aug,
doi = "10.3201/eid2008.131897",
language = "English",
volume = "20",
pages = "1280--6",
journal = "Emerging Infectious Diseases",
issn = "1080-6040",
publisher = "CDC Centers for Disease Control and Prevention",
number = "8",

}

RIS

TY - JOUR

T1 - Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia

AU - Alifrangis, Michael

AU - Nag, Sidsel

AU - Schousboe, Mette L

AU - Ishengoma, Deus

AU - Lusingu, John

AU - Pota, Hirva

AU - Kavishe, Reginald A

AU - Pearce, Richard

AU - Ord, Rosalynn

AU - Lynch, Caroline

AU - Dejene, Seyoum

AU - Cox, Jonathan

AU - Rwakimari, John

AU - Minja, Daniel T R

AU - Lemnge, Martha M

AU - Roper, Cally

PY - 2014/8

Y1 - 2014/8

N2 - Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine-pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps and the triple-mutant Pfdhfr. Using samples collected during 2004-2008, we investigated the evolutionary origin of the A581G mutation by characterizing microsatellite diversity flanking Pfdhps triple-mutant (437G+540E+581G) alleles from 3 locations in eastern Africa and comparing it with double-mutant (437G+540E) alleles from the same area. In Ethiopia, both alleles derived from 1 lineage that was distinct from those in Uganda and Tanzania. Uganda and Tanzania triple mutants derived from the previously characterized southeastern Africa double-mutant lineage. The A581G mutation has occurred multiple times on local Pfdhps double-mutant backgrounds; however, a novel microsatellite allele incorporated into the Tanzania lineage since 2004 illustrates the local expansion of emergent triple-mutant lineages.

AB - Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine-pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps and the triple-mutant Pfdhfr. Using samples collected during 2004-2008, we investigated the evolutionary origin of the A581G mutation by characterizing microsatellite diversity flanking Pfdhps triple-mutant (437G+540E+581G) alleles from 3 locations in eastern Africa and comparing it with double-mutant (437G+540E) alleles from the same area. In Ethiopia, both alleles derived from 1 lineage that was distinct from those in Uganda and Tanzania. Uganda and Tanzania triple mutants derived from the previously characterized southeastern Africa double-mutant lineage. The A581G mutation has occurred multiple times on local Pfdhps double-mutant backgrounds; however, a novel microsatellite allele incorporated into the Tanzania lineage since 2004 illustrates the local expansion of emergent triple-mutant lineages.

U2 - 10.3201/eid2008.131897

DO - 10.3201/eid2008.131897

M3 - Journal article

C2 - 25061906

VL - 20

SP - 1280

EP - 1286

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 8

ER -

ID: 119725232