In vivo sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine-pyrimethamine among schoolchildren in rural Uganda: A comparison between 1995 and 1998
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Sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine- pyrimethamine was tested among asymptomatic school children in 1995 and 1998 using a modified in vivo test with examination for parasitaemia on day 0, 2 and 7. Sensitivity (S/RI) to chloroquine in 'urban' areas was found in 42% in 1995 and 62% in 1998 with resistance at the RII/RIII level observed in 58 and 38%, respectively (P<0.01). In 'rural' areas, sensitivity to chloroquine was 76% in 1995 and 72% in 1998 (P = 0.6) with resistance at the RII/RIII level observed in 24 and 18%, respectively (P = 0.4). Sensitivity to sulfadoxine- pyrimethamine was found in 98 and 99% in 1995 and 1998, respectively. The apparent improvement in sensitivity to chloroquine in 'urban' areas might be due to a different school being included in the two studies. It is concluded that the pattern of sensitivity of P. falciparum to chloroquine and sulfadoxine-pyrimethamine has not changed over a period of 2.5 year. (C) 2000 Elsevier Science B.V.
Original language | English |
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Journal | Acta Tropica |
Volume | 76 |
Issue number | 3 |
Pages (from-to) | 265-270 |
Number of pages | 6 |
ISSN | 0001-706X |
DOIs | |
Publication status | Published - 2 Oct 2000 |
- Chloroquine, Drug resistance, Plasmodium falciparum, Sulfadoxine- pyrimethamine, Uganda
Research areas
ID: 224707907