Immunoglobulin M: restrainer of inflammation and mediator of immune evasion by Plasmodium falciparum malaria
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Immunoglobulin M : restrainer of inflammation and mediator of immune evasion by Plasmodium falciparum malaria. / Pleass, Richard J; Moore, Shona C; Stevenson, Liz; Hviid, Lars.
In: Trends in Parasitology, Vol. 32, No. 2, 02.2016, p. 108-119.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Immunoglobulin M
T2 - restrainer of inflammation and mediator of immune evasion by Plasmodium falciparum malaria
AU - Pleass, Richard J
AU - Moore, Shona C
AU - Stevenson, Liz
AU - Hviid, Lars
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2016/2
Y1 - 2016/2
N2 - Immunoglobulin M (IgM) is an ancient antibody class that is found in all vertebrates, with the exception of coelacanths, and is indispensable in both innate and adaptive immunity. The equally ancient human malaria parasite, Plasmodium falciparum, formed an intimate relationship with IgM with which it co-evolved. In this article, we discuss the association between IgM and human malaria parasites, building on several recent publications that implicate IgM as a crucial molecule that determines both host and parasite survival. Consequently, a better understanding of this association may lead to the development of improved intervention strategies.
AB - Immunoglobulin M (IgM) is an ancient antibody class that is found in all vertebrates, with the exception of coelacanths, and is indispensable in both innate and adaptive immunity. The equally ancient human malaria parasite, Plasmodium falciparum, formed an intimate relationship with IgM with which it co-evolved. In this article, we discuss the association between IgM and human malaria parasites, building on several recent publications that implicate IgM as a crucial molecule that determines both host and parasite survival. Consequently, a better understanding of this association may lead to the development of improved intervention strategies.
U2 - 10.1016/j.pt.2015.09.007
DO - 10.1016/j.pt.2015.09.007
M3 - Review
C2 - 26597020
VL - 32
SP - 108
EP - 119
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 2
ER -
ID: 154481979